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ASAP3 AcK311 EZR AcK60 AcK253 AcK263 AcK258 Protein 1, 2 PTM Negative regulation of hsa-miR-199a-5p leading to the increased expression of FZD4(towards Wnt/beta-catenin signaling) Proliferation and differentiation in Tu686, 6-10B and FaDu cells Lactate production in PC3 cells CCL18 Signaling Pathway Ligand Proliferation, migration, invasion and EMT in HSC6 and CAL27 cells Directional migration of MDA-MB-231 cells Proliferation, and metastasis of HSC6 oral carcinoma cells Proliferation of HSC6 and CAL27 cells Myofibroblast differentiation of breast phyllodes tumors Secretion from monocytes/macrophages that support hematopoiesis Switching of CD4+CD45RO+CD25- T cells into CD4+CD25+Foxp3+ regulatory T cells Dissociation Invasion in HEEC,ECA109, KYSE30, KYSE140 KYSE510, and TE-1 cells Tumor-associated macrophage-induced metastasis of MDA-MB-231 cells Migration & invasion of SMMC-7721 cells In OS-RC-2 and ACHN cells Abrogates chemotactic responses induced by their ligands Invasion and migration of MGC-803, GES-1 and MKN28 cells EMT in Ishikawa cells Migration and tube formation in HUVECs EMT in MDA-MB-231 and MCF-7 cells Migration and invasion of BxPC-3 and PANC-1 cells Enhances ECM adherence of MDA-MB-231 cells Adhesion and F-actin polymerization Migration of MDA-MB-231 and SKBR3 cells Polymerization of F-actin and Cytoskeleton reorganization in A549 and H1299 cells Migration and invasion of PANC-1 and Capan-2 cells Maintenance of the Warburg effect Endothelial-Mesenchymal Transformation (EndMT) in HUVECs Induction of EMT and stemness in Tu686 and FaDu cells EMT in HSC6 and CAL33 cells Migration of CaOV3 and OVCAR3 cells Migration and invasion of 5637 bladder cancer cells Proliferation, invasion and iigration of Skov3 cells Modulation of CXCR4 activity Nuclear Gi-alpha dependent Motility of MDA-MB-231 cells EMT and invasion of MDA-MB-231 and MCF-7 cells lnc-DENND3-2 FZD4 Ca++ CCR6 GSK3B S9 PLCG1 P PIP2 PITPNM3 P hsa-miR-199a-5p CCR8 VIM CDH5 CDH1 MAPK3 T202 Y204 3 CHUK S176 S180 MAPK1 T185 Y187 HOTAIR STAT3 Y705 AKT1 S473 T308 CDH2 FN1 PRKCZ P ITPKB PTK2B Y402 SRC Y419 PTK2 Y397 ITGA5 ITGB1 T789 T788 ANXA2 Y24 FN1 GPER1 VCAM1 VCAM1 RELA S536 RELA S536 ZEB2 JAK2 Y1007 Y1008 CDH1 CDH2 VIM FN1 EMT in Tu686, 6-10B and FaDu cells MTDH Metastasis and EMT in Tu686, 6-10B and FaDu cells NFKBIA S32 VEGFC CDH1 MMP2 Proliferation and migration of MG63 and 143B osteosarcoma cells FAM74A4 lnc-FLNA-1 TCRB TTLL3 HIPK1-AS1 lnc-MACC1-1 MTERF4 UCA1 lnc-SLC35A5-1 LINC02245 lnc-COL5A1-3 ATE1-AS1 GOLGA6L17P LINC01881 lnc-ASAP2-5 TFAP2A ATF3 STAT1 EP300 TEAD4 EP300 LINC00319 LINC01357 lnc-GOLGA8Q-1 MYOSLID-AS1 MIAT lnc-U2AF2-2 lnc-PYGL-1 lnc-RGMA-3 LINC00649 ATP6VOE2-AS1 lnc-FANCM-1 VASH1-AS1 lnc-SSU72P8-2 lnc-ESRRB-1 lnc-SLC16A3-3 LINC00266-3 LINC01089 RAD51-AS1 LINC02582 LINC00467 ECI2-DT lnc-ZBTB20-1 LINC00629 LINC01770 lnc-ZFP37-1 LINC01361 PPM1K-DT lnc-SCN8A-1 PRKAR1B-AS1 LINC00974 lnc-PMAIP1-9 POT1-AS1 BCYRN1 Collagen production in pulmonary fibroblasts IKBKB ARF6 GTP IKBKG ARF6 GTP PM CY ASAP3 AcK311 KAT2B ASAP1 Y782 Adhesion, migration and invasion of MCF-7 cells MMP3 CDH1 SNAI2 PTK2B Y402 KITLG CDH1 CXCL8 SNAI1 CASP8 VEGFA TIMP1 IL6 CCR8 Receptor internalization NRAS LIN28B hsa-miR-98-5p hsa-miR-27b-3p IKBKB S181 S177 CDH1 VIM PTK2 VIM SNAI1 SP1 P SMAD2 P SMAD3 P COL1A1 Migration and invasion of MDA-MB-231 cells Hematopoiesis in myeloid long-term bone marrow cultures IL15 CCL2 CCL3 TIMP2 TGFB1 FGF2 MAD1L1 CREB1 FOS MAPK8 T183 Y185 MAPK9 T183 Y185 ELMO1 KIF5B MT-CO2 CSF2 MMP9 CXCR4 MTOR S2481 S2448 ACTA2 ACTA2 hsa-miR-21-5p Integrin clustering Attenuation of PIP2 binding associated activation of Ezrin by acetylation PRKCA P PRKCA P Production of Collagen in fibroblasts COL1A2 COL1A2 CCR3 CCR1 CCR2 CCR4 CCR5 Antagonistic activity RAC1 GTP Invasion and migration of A549 and H1299 cells CDH1 CDH2 POU5F1 BMI1 Induces stem cell-like characteristics in HSC6, CAL33 and SCC15 cells SNAI2 SNAI1 Decreased expression of PTEN (inhibitor of AKT activity) regulated by hsa-miR-21-5p PRKCD CDH1 MTDH TWIST1 CDH1 CDH2 VIM KIF5B CDH1 VIM ALDH1 CDH1 VIM CDH1 CD44 LIN28A SNAI1 SNAI2 TWIST1 ZEB1 ZEB2 LIMK1 T508 CFL1 S3 Cytoskeleton reorganization in MDA-MB-231 cells PM CY PM CY EZR AcK253 AcK60 AcK263 AcK258 ARF6 rich membrane protrusions Dissociation and increased ARF6 activity PM CY PM CY ASAP1 Y782 Activation of LFA-1 in polarised Th2-cells ITGAL ITGB2 PM CY Release of intracellular TGFB1 IL10 Secretion in memory CD4+ T cells CY NU Dissociation and activation of NF-kappaB CY NU PIK3R3 Y199 PIK3R1 Y467 PTEN hsa-miR-92b hsa-miR-26b hsa-miR-877 hsa-miR-27a hsa-miR-106a hsa-miR-17 hsa-miR-20b hsa-let-7e hsa-miR-20a hsa-let-7b hsa-let-7d Post-transcriptional regulation of hsa-miR-98-5p TWIST1 CDH1 CDH2 VIM Releasefrom leukocytes F-actin polymerization in Th2 cells VEGFC CDH1 MMP2 mRNAs LncRNAs FZD4 PTEN CCL18 CCL18 CCL18 CCL18 CCL18 CCL18 Receptor Molecule Protein-protein interactions Protein-protein dissociation Protein RNA Small molecule / metabolite Protein 1 Protein 2 Protein complex Protein 1 Protein 2 Group of genes or proteins from a study or gene family Acetylation RNA Protein Post-Translational Modification Protein PTM Protein PTM Phosphosites Acetylation sites Reported to be CCR8-mediated Reported to be PITPNM3-mediated Leads to through known unknown mechanisms (Multiple colored edges to disctinguish the crossing edges) Cytoplasm Plasma membrane Nucleus Protein transport across cellular compartments PM CY NU Leads to transcriptional or translational regulation Figure Legend Inhibition of activity CDC25C SNAI2 SNAI1 CD44 PROM1 LDHA LDHB LDHA LDHB SLC2A1 HIF1A MYC ARNT Histamine
Description
A multi-cellular molecular signaling and functional network map of C-C Motif Chemokine Ligand 18 (CCL18): A chemokine with immunosuppressive and pro-tumor function
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Bibliography
Krohn SC, Bonvin P, Proudfoot AE; ''CCL18 exhibits a regulatory role through inhibition of receptor and glycosaminoglycan binding.''; PLoS One, 2013 PubMed Europe PMC Scholia Nibbs RJ, Salcedo TW, Campbell JD, Yao XT, Li Y, Nardelli B, Olsen HS, Morris TS, Proudfoot AE, Patel VP, Graham GJ; ''C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap.''; J Immunol, 2000 PubMed Europe PMC Scholia Lin X, Chen L, Yao Y, Zhao R, Cui X, Chen J, Hou K, Zhang M, Su F, Song E; ''CCL18-mediated down-regulation of miR98 and miR27b promotes breast cancer metastasis.''; Oncotarget, 2015 PubMed Europe PMC Scholia History
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