T-cell activation SARS-CoV-2 (Homo sapiens)

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Endoplasmatic Reticulum4723, 25-273, 313913, 23, 2523, 252, 414623, 25723, 25, 29, 3223, 25205, 24, 458, 18, 283, 319, 40263, 3126463846461413, 23, 2512221423, 25, 2712, 17, 374, 101, 12, 33, 34, 441446LysosomeNucleusAntigen presenting cell (APC)Naive T-cellHLA-DRACa2+SARS-CoV-2 SpikeHLA-DRAHLA-DRB1HLA-DRB1TRATRBCD247CD247CD3ECD3DCD3ECD3GLATCD80CD4LCKZAP70CD28PIK3R1PDPK1AKT1mTORGSK3BTSC2NFATC1PLCG1PPP33CGRB2SOS1RASGRP1HRASRAF1MAP2K1MAPK346ITPR1PRKCQNFKB1RHEBmTORTSC1NFATC1ICOSCARD11BCL10MALT126CHUKIKBKBIKBKGNFKBIAProliferationCell GrowthGlucose MetabolismPTPRCFYNRELANFKB1RELAJUNFOSJUNFOSSARS-CoVSpike proteinFOXO330CTLA4TYK2JAK2IL12RB2STAT416IL23R16STAT4STAT4STAT4STAT4IFNAR1IL12AIL23AIL12BIL12RB1IL12RB1TYK2JAK2IL12BIFNAR2CCND1Cell Cycle ControlIL26, 11, 35, 42, 4336CDKN2A CCND1TP53 CDKN1AIRF2BPL15MYD88IFNGTNFIL18R1IL12RB2LCP2GRAP2PIP2NFAT213, 23, 25PIP214PIK3CDPTENIFNGIL4IL17ACCL19CCL28IL12BIL12ATLATNFIFNGIL23AIFNB1MLST8DeptorRaptorCD8619, 2119, 21BAXBCL2L1 IL12BIL12AIL2DEPTORMLST8RICTORCa2+IP3DAGPIP3MAP2K2MAPK1


Description

T-cell activation SARS-CoV-2 (Work in Progress)

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Ontology Terms

 

Bibliography

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  15. Good SR, Thieu VT, Mathur AN, Yu Q, Stritesky GL, Yeh N, O'Malley JT, Perumal NB, Kaplan MH; ''Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming.''; J Immunol, 2009 PubMed Europe PMC Scholia
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  33. Huber RG, Fan H, Bond PJ; ''The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain.''; PLoS Comput Biol, 2015 PubMed Europe PMC Scholia
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  38. C. Martinez Calejman, S. Trefely, S. W. Entwisle, A. Luciano, S. M. Jung, W. Hsiao, A. Torres, C. M. Hung, H. Li, N. W. Snyder, J. Villén, K. E. Wellen, D. A. Guertin; ''mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis''; Nature, 2020 PubMed Europe PMC Scholia
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  41. Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D; ''Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.''; Cell, 2020 PubMed Europe PMC Scholia
  42. Pietilä TE, Veckman V, Lehtonen A, Lin R, Hiscott J, Julkunen I; ''Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells.''; J Immunol, 2007 PubMed Europe PMC Scholia
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  46. Rincón M; ''MAP-kinase signaling pathways in T cells.''; Curr Opin Immunol, 2001 PubMed Europe PMC Scholia
  47. Rodriguez Gama A, Miller T, Lange JJ, Unruh JR, Halfmann R; ''A nucleation barrier spring-loads the CBM signalosome for binary activation.''; Elife, 2022 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129246view02:40, 16 March 2024EweitzOntology Term : 'naive T cell' added !
129245view02:39, 16 March 2024EweitzOntology Term : 'professional antigen presenting cell' added !
125315view21:43, 31 January 2023LarsgwAdd PMID to reference
124943view15:41, 3 January 2023EgonwAdded a reference for the CARD11-BLC10-MALT1 complex
124801view21:24, 11 December 2022AlexanderPicoOntology Term : 'T cell' added !
124800view21:24, 11 December 2022AlexanderPicoOntology Term : 'COVID-19' added !
124799view21:22, 11 December 2022AlexanderPicofixed citations
119538view21:24, 13 July 2021Mkutmonfix unconnected line
119489view14:24, 2 July 2021ClclassChanged NFAT2 to NFATC1
119483view08:34, 2 July 2021EgonwNot a mim-conversion and correct ID for Ca2+
119480view11:39, 1 July 2021Clclassenlarged data nodes
119479view10:56, 1 July 2021Clclassenlarged data nodes
119478view10:52, 1 July 2021ClclassEnlarged data nodes, changed gene annotations
119476view20:09, 30 June 2021MkutmonOntology Term : 'T cell' added !
119475view20:09, 30 June 2021MkutmonOntology Term : 'COVID-19' added !
119471view06:27, 30 June 2021EgonwNot mim-conversions
119180view14:10, 20 June 2021ClclassAdded literature annotations
119179view12:58, 20 June 2021Clclassadded transcription targets
119178view10:16, 20 June 2021Clclassadded literatur annotations
119177view10:05, 20 June 2021ClclassAdded CD86
119176view10:04, 20 June 2021ClclassAdded data nodes
119175view08:50, 20 June 2021ClclassAdded annotations
119165view12:39, 19 June 2021ClclassAdded data nodes
119158view12:37, 18 June 2021ClclassAdded transcriptional targets and identifiers
119095view08:35, 17 June 2021FinterlyAdded PubMed IDs
119065view08:59, 14 June 2021ClclassAdded literature annotations
119051view12:24, 12 June 2021ClclassAdded literature reference
119050view11:55, 12 June 2021ClclassAdded data nodes
119049view09:57, 12 June 2021ClclassAdded Uniprot identifiers
119048view09:54, 12 June 2021ClclassAdded Uniprot identifiers
119047view09:19, 12 June 2021ClclassAdded Uniprot identifiers
119046view09:01, 12 June 2021ClclassAdded Uniprot identifiers
119032view10:21, 11 June 2021ClclassDeleted a pathway
119031view10:01, 11 June 2021ClclassAdded new pathways and annotations
118982view13:28, 6 June 2021ClclassAdded Data nodes and Literature references
118643view13:22, 31 May 2021ClclassAdded Literature Annotations
118614view07:15, 31 May 2021ClclassAdded Literature Annotations
118556view11:47, 28 May 2021ClclassAdded Literature Annotations
118123view18:24, 24 May 2021ClclassAdded Literature Annotations
118122view18:11, 24 May 2021ClclassAdded Literature Annotations
117102view11:45, 17 May 2021ClclassAdded literature annotations
116776view09:49, 14 May 2021EweitzModified title
116755view08:17, 12 May 2021ClclassUpdated description
116754view08:14, 12 May 2021ClclassNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1ProteinP31749 (Uniprot-TrEMBL)
BAXProteinQ07812 (Uniprot-TrEMBL)
BCL10ProteinO95999 (Uniprot-TrEMBL)
BCL2L1 ProteinQ07817 (Uniprot-TrEMBL)
CARD11ProteinQ9BXL7 (Uniprot-TrEMBL)
CCL19ProteinQ99731 (Uniprot-TrEMBL)
CCL28ProteinQ9NRJ3 (Uniprot-TrEMBL)
CCND1ProteinP24385 (Uniprot-TrEMBL)
CD247ProteinP20963 (Uniprot-TrEMBL)
CD28ProteinP10747 (Uniprot-TrEMBL)
CD3DProteinP04234 (Uniprot-TrEMBL)
CD3EProteinP07766 (Uniprot-TrEMBL)
CD3GProteinP09693 (Uniprot-TrEMBL)
CD4ProteinP01730 (Uniprot-TrEMBL)
CD80ProteinP33681 (Uniprot-TrEMBL)
CD86ProteinP42081 (Uniprot-TrEMBL)
CDKN1AProteinP38936 (Uniprot-TrEMBL)
CDKN2A ProteinP42771 (Uniprot-TrEMBL)
CHUKProteinO15111 (Uniprot-TrEMBL)
CTLA4ProteinP16410 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI compound)
DAGMetabolite84974 (ChEBI)
DEPTORProteinQ8TB45 (Uniprot-TrEMBL)
DeptorProteinQ8TB45 (Uniprot-TrEMBL)
FOSProteinP01100 (Uniprot-TrEMBL)
FOXO3ProteinO43524 (Uniprot-TrEMBL)
FYNProteinP06241 (Uniprot-TrEMBL)
GRAP2ProteinO75791 (Uniprot-TrEMBL)
GRB2ProteinP62993 (Uniprot-TrEMBL)
GSK3BProteinP49841 (Uniprot-TrEMBL)
HLA-DRAProteinP01903 (Uniprot-TrEMBL)
HLA-DRB1ProteinP01911 (Uniprot-TrEMBL)
HLA-DRB1ProteinP79483 (Uniprot-TrEMBL)
HRASProteinP01112 (Uniprot-TrEMBL)
ICOSProteinQ9Y6W8 (Uniprot-TrEMBL)
IFNAR1ProteinP17181 (Uniprot-TrEMBL)
IFNAR2ProteinP48551 (Uniprot-TrEMBL)
IFNB1ProteinP01574 (Uniprot-TrEMBL)
IFNGProteinP01579 (Uniprot-TrEMBL)
IKBKBProteinO14920 (Uniprot-TrEMBL)
IKBKGProteinQ9Y6K9 (Uniprot-TrEMBL)
IL12AProteinP29459 (Uniprot-TrEMBL)
IL12BProteinP29460 (Uniprot-TrEMBL)
IL12RB1ProteinP42701 (Uniprot-TrEMBL)
IL12RB2ProteinQ99665 (Uniprot-TrEMBL)
IL17AProteinQ16552 (Uniprot-TrEMBL)
IL18R1ProteinQ13478 (Uniprot-TrEMBL)
IL23AProteinQ9NPF7 (Uniprot-TrEMBL)
IL23RProteinQ5VWK5 (Uniprot-TrEMBL)
IL2ProteinP60568 (Uniprot-TrEMBL)
IL4ProteinP05112 (Uniprot-TrEMBL)
IP3Metabolite139109 (ChEBI)
IRF2BPLProteinQ9H1B7 (Uniprot-TrEMBL)
ITPR1ProteinQ14643 (Uniprot-TrEMBL)
JAK2ProteinO60674 (Uniprot-TrEMBL)
JUNProteinP05412 (Uniprot-TrEMBL)
LATProteinO43561 (Uniprot-TrEMBL)
LCKProteinP06239 (Uniprot-TrEMBL)
LCP2ProteinQ13094 (Uniprot-TrEMBL)
MALT1ProteinQ9UDY8 (Uniprot-TrEMBL)
MAP2K1ProteinQ02750 (Uniprot-TrEMBL)
MAP2K2ProteinP36507 (Uniprot-TrEMBL)
MAPK1ProteinP28482 (Uniprot-TrEMBL)
MAPK3ProteinP27361 (Uniprot-TrEMBL)
MLST8ProteinQ9BVC4 (Uniprot-TrEMBL)
MYD88ProteinQ99836 (Uniprot-TrEMBL)
NFAT2ProteinO95644 (Uniprot-TrEMBL)
NFATC1ProteinO95644 (Uniprot-TrEMBL)
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NFKBIAProteinP25963 (Uniprot-TrEMBL)
PDPK1ProteinO15530 (Uniprot-TrEMBL)
PIK3CDProteinO00329 (Uniprot-TrEMBL)
PIK3R1ProteinP27986 (Uniprot-TrEMBL)
PIP2Metabolite145877 (ChEBI)
PIP3Metabolite84238 (ChEBI)
PLCG1ProteinP19174 (Uniprot-TrEMBL)
PPP33CProteinP48454 (Uniprot-TrEMBL)
PRKCQProteinQ04759 (Uniprot-TrEMBL)
PTENProteinP60484 (Uniprot-TrEMBL)
PTPRCProteinP08575 (Uniprot-TrEMBL)
RAF1ProteinP04049 (Uniprot-TrEMBL)
RASGRP1ProteinO95267 (Uniprot-TrEMBL)
RELAProteinQ04206 (Uniprot-TrEMBL)
RHEBProteinQ15382 (Uniprot-TrEMBL)
RICTORProteinQ6R327 (Uniprot-TrEMBL)
RaptorProteinQ8N122 (Uniprot-TrEMBL)
SARS-CoV-2 SpikeProteinP0DTC2 (Uniprot-TrEMBL)
SOS1ProteinQ07889 (Uniprot-TrEMBL)
STAT4ProteinQ14765 (Uniprot-TrEMBL)
TLAProteinP01374 (Uniprot-TrEMBL)
TNFProteinP01375 (Uniprot-TrEMBL)
TP53 ProteinP04637 (Uniprot-TrEMBL)
TRAProteinP0DTU3 (Uniprot-TrEMBL)
TRBProteinP0DTU4 (Uniprot-TrEMBL)
TSC1ProteinQ92574 (Uniprot-TrEMBL)
TSC2ProteinP49815 (Uniprot-TrEMBL)
TYK2ProteinP29597 (Uniprot-TrEMBL)
ZAP70ProteinP43403 (Uniprot-TrEMBL)
mTORProteinP42345 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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