Oxylipins pathways (Mus musculus)

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1, 2Delta6 elongaseHpgdEphx2 (sEH)11-HETELAAA8-iso-PGF2alphaPGH2TXA2TXB2PGE211b-PGE2PGA2PGB215-keto-PGE213,14-Dihydro-15-keto-PGE2PGD2PGK2PGJ215d-PGJ211beta-PGF2alpha13,14-Dihydro-15-keto-PGF2alpha13,14-Dihydro-15-keto-PGD22,3-dinor-11beta-PGF2alphaPGF2alpha15-keto PGF2alpha6-keto-PGF1alphaPGI213,14-Dihydro-15-keto-PGF2alpha13,14-Dihydro-PGF2alpha6-keto PGE115(R)-HpETE15(R)-HETE15-epi-LXA415-epi-LXB420-HETE9-HETE5(6)-EET8(9)-EET11(12)-EET14(15)-EET5(6)-DHET8(9)-DHET11(12)-DHET14(15)-DHET15(S)-HpETELXB415(S)-HETE14,15-LTE4LXA48,15-DiHETE15-oxoETE12(S)-HpETE12(S)-HETE12-oxoETE8(S)-HpETE8(S)-HETE5-HpETE5-HETE5,15-diHETELTA4LTC4LTD4LTE4LTB46-trans-LTB411-trans-LTD411-trans-LTE420-hydroxy-LTB420-carboxy-LTB4DGLA9,10-EpOME12,13-EpOME9,10-DiHOME12,13-DiHOME9-HpODE9-HODE9-oxoODE9,10,13-TriHOME13-HpODE9,12,13-TriHOME13-oxoODE13-HODEEPA18R-HEPERvE114(15)-EpETE14,15-DiHETE17(18)-EpETE17,18-DiHETE5-HEPE12-HEPE12-HpEPE15-HEPE15-HpEPE5-HpEPE8-HEPE11-HEPERvE118-HEPE9-HEPEALADHA4-HpDHA4-HDHA7-HDHA7-HpDHA11-HDHA11-HpDHA14-HDHA14-HpDHAMar1RvD117R-HDHA17-HpDHA17-HDHAPD1PDXRvD1RvD210-HDHA13-HDHA20-HDHAnon-enzymaticCOX/non-enzymaticnon-enzymaticnon-enzymaticInflammatory Pathways (omega-6 derived)Anti-inflammatory Pathways (omega-3 derived)15-HETrE8-iso-PGE2non-enzymaticnon-enzymaticPtgfsPtdgsPtgesPtgisTbxas1Alox5Alox8Alox12Alox15Fads1Alox15Fads2Ac-COX(aspirin triggered)Ptgs1/2Ltc4sLta4hGgt1Dpep1Alox15Alox12aspirin-treated COX2CYPCYP5-oxoETEAc-COX(aspirin triggered)Alox1516(R)-HETECYPAlox15Alox5Alox12Alox15CYPAc-COX(aspirin triggered)Alox15Alox12Alox5Alox5sEHFads2Fads1ElongaseElongaseElongaseFads2Peroxisomal beta-oxidationGPX1GPX112-Keto-LTB4Cbr119(S)-HETEHpgdsEphx2 (sEH)Ephx2 (sEH)Ephx2 (sEH)Ephx2 (sEH)


Description

Oxylipins derived from AA, DGLA, LA, EPA, ALA and DHA

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Quality Tags

Ontology Terms

 

Bibliography

  1. Astarita G, Kendall AC, Dennis EA, Nicolaou A; ''Targeted lipidomic strategies for oxygenated metabolites of polyunsaturated fatty acids''; Biochim Biophys Acta, 2015 PubMed Europe PMC Scholia
  2. Tam VC; ''Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections''; Semin Immunol., 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134179view07:49, 16 July 2024EgonwRemoved empty xrefs
130618view04:45, 29 May 2024KhanspersOntology Term : 'classic metabolic pathway' added !
129536view01:52, 9 May 2024EweitzModified title
129506view08:02, 3 May 2024Ash iyerFont size increased.
129505view07:55, 3 May 2024Ash iyerModified description
129504view07:54, 3 May 2024Ash iyerModified title
129503view07:54, 3 May 2024Ash iyerModified title
129502view07:52, 3 May 2024Ash iyerModified description
129490view21:41, 30 April 2024Khanspersupdated PMIDs (to fix broken linkouts), switched gene product for pathway node for peroxisomal beta oxidation
129489view20:29, 30 April 2024Khanspersconnected interactions
129003view12:40, 1 March 2024FriolsChange abbreviations of a few prostanoid compounds
120709view18:35, 23 December 2021MaintBotOntology Term : 'fatty acid biosynthetic pathway' added !
120219view10:00, 14 November 2021EgonwFixed a datasource
120216view16:01, 11 November 2021FriolsChange Line Styles
120203view10:03, 10 November 2021FriolsNode corrections
120202view10:49, 9 November 2021FriolsAnnotate nodes
120201view08:50, 9 November 2021FriolsFix interactions
120198view13:50, 8 November 2021FriolsSpecify identifiers
120195view09:18, 8 November 2021FriolsAdd literature references
120194view08:42, 8 November 2021FriolsModified description
120193view08:28, 8 November 2021FriolsModified title
120192view07:48, 8 November 2021FriolsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
10-HDHAMetaboliteCHEBI:72640 (ChEBI)
11(12)-DHETMetaboliteCHEBI:63969 (ChEBI)
11(12)-EETMetaboliteCHEBI:34130 (ChEBI)
11-HDHAMetaboliteCHEBI:72794 (ChEBI)
11-HEPEMetaboliteCHEBI:131889 (ChEBI)
11-HETEMetaboliteCHEBI:138332 (ChEBI)
11-HpDHAMetaboliteCHEBI:156131 (ChEBI)
11-trans-LTD4MetaboliteCHEBI:140493 (ChEBI)
11-trans-LTE4MetaboliteCHEBI:72779 (ChEBI)
11b-PGE2MetaboliteCHEBI:140932 (ChEBI)
11beta-PGF2alphaMetaboliteCHEBI:27595 (ChEBI)
12(S)-HETEMetaboliteCHEBI:34146 (ChEBI)
12(S)-HpETEMetaboliteCHEBI:15626 (ChEBI)
12,13-DiHOMEMetaboliteCHEBI:72665 (ChEBI)
12,13-EpOMEMetaboliteCHEBI:38299 (ChEBI)
12-HEPEMetaboliteCHEBI:88345 (ChEBI)
12-HpEPEMetaboliteCHEBI:78909 (ChEBI)
12-Keto-LTB4MetaboliteCHEBI:27814 (ChEBI)
12-oxoETEMetaboliteCHEBI:34151 (ChEBI)
13,14-Dihydro- 15-keto-PGD2MetaboliteCHEBI:72603 (ChEBI)
13,14-Dihydro- 15-keto-PGF2alphaMetabolite
13,14-Dihydro- 15-keto-PGF2alphaMetaboliteCHEBI:63976 (ChEBI)
13,14-Dihydro-15-keto-PGE2MetaboliteCHEBI:15550 (ChEBI)
13,14-Dihydro-PGF2alphaMetaboliteCHEBI:88346 (ChEBI)
13-HDHAMetaboliteCHEBI:72608 (ChEBI)
13-HODEMetaboliteCHEBI:34154 (ChEBI)
13-HpODEMetaboliteCHEBI:91272 (ChEBI)
13-oxoODEMetaboliteCHEBI:72815 (ChEBI)
14(15)-DHETMetaboliteCHEBI:63966 (ChEBI)
14(15)-EETMetaboliteCHEBI:34157 (ChEBI)
14(15)-EpETEMetaboliteCHEBI:88457 (ChEBI)
14,15-DiHETEMetaboliteCHEBI:88459 (ChEBI)
14,15-LTE4MetaboliteCHEBI:63986 (ChEBI)
14-HDHAMetaboliteCHEBI:137347 (ChEBI)
14-HpDHAMetaboliteCHEBI:140279 (ChEBI)
15(R)-HETEMetaboliteCHEBI:63989 (ChEBI)
15(R)-HpETEMetaboliteCHEBI:82627 (ChEBI)
15(S)-HETEMetaboliteCHEBI:15558 (ChEBI)
15(S)-HpETEMetaboliteCHEBI:15628 (ChEBI)
15-HEPEMetaboliteCHEBI:88347 (ChEBI)
15-HETrEMetaboliteCHEBI:88348 (ChEBI)
15-HpEPEMetabolite6438853 (PubChem-compound)
15-epi-LXA4MetaboliteCHEBI:72789 (ChEBI)
15-epi-LXB4MetaboliteCHEBI:63991 (ChEBI)
15-keto PGF2alphaMetaboliteCHEBI:28442 (ChEBI)
15-keto-PGE2MetaboliteCHEBI:15547 (ChEBI)
15-oxoETEMetaboliteCHEBI:15559 (ChEBI)
15d-PGJ2MetaboliteCHEBI:34159 (ChEBI)
16(R)-HETEMetaboliteCHEBI:34162 (ChEBI)
17(18)-EpETEMetaboliteCHEBI:72853 (ChEBI)
17,18-DiHETEMetaboliteCHEBI:88349 (ChEBI)
17-HDHAMetaboliteCHEBI:72637 (ChEBI)
17-HpDHAMetaboliteCHEBI:136113 (ChEBI)
17R-HDHAMetaboliteCHEBI:91137 (ChEBI)
18-HEPEMetaboliteCHEBI:72802 (ChEBI)
18R-HEPEMetaboliteCHEBI:81563 (ChEBI)
19(S)-HETEMetaboliteCHEBI:34185 (ChEBI)
2,3-dinor-11beta-PGF2alphaMetaboliteCHEBI:165323 (ChEBI)
20-HDHAMetaboliteCHEBI:72615 (ChEBI)
20-HETEMetaboliteCHEBI:34306 (ChEBI)
20-carboxy-LTB4MetaboliteCHEBI:27562 (ChEBI)
20-hydroxy-LTB4MetaboliteCHEBI:15646 (ChEBI)
4-HDHAMetaboliteCHEBI:72624 (ChEBI)
4-HpDHAMetabolite
5(6)-DHETMetaboliteCHEBI:63974 (ChEBI)
5(6)-EETMetaboliteCHEBI:34450 (ChEBI)
5,15-diHETEMetaboliteCHEBI:72867 (ChEBI)
5-HEPEMetaboliteCHEBI:140934 (ChEBI)
5-HETEMetaboliteCHEBI:28209 (ChEBI)
5-HpEPEMetaboliteCHEBI:145815 (ChEBI)
5-HpETEMetaboliteCHEBI:91268 (ChEBI)
5-oxoETEMetaboliteCHEBI:52449 (ChEBI)
6-keto PGE1MetaboliteCHEBI:28269 (ChEBI)
6-keto-PGF1alphaMetaboliteCHEBI:28158 (ChEBI)
6-trans-LTB4MetaboliteCHEBI:63981 (ChEBI)
7-HDHAMetaboliteCHEBI:72623 (ChEBI)
7-HpDHAMetaboliteCHEBI:156049 (ChEBI)
8(9)-DHETMetaboliteCHEBI:63970 (ChEBI)
8(9)-EETMetaboliteCHEBI:34490 (ChEBI)
8(S)-HETEMetaboliteCHEBI:34486 (ChEBI)
8(S)-HpETEMetaboliteCHEBI:34487 (ChEBI)
8,15-DiHETEMetaboliteCHEBI:88456 (ChEBI)
8-HEPEMetaboliteCHEBI:157747 (ChEBI)
8-iso-PGE2MetaboliteCHEBI:131888 (ChEBI)
8-iso-PGF2alphaMetaboliteCHEBI:34505 (ChEBI)
9,10,13-TriHOMEMetaboliteCHEBI:34499 (ChEBI)
9,10-DiHOMEMetaboliteCHEBI:72663 (ChEBI)
9,10-EpOMEMetaboliteCHEBI:34494 (ChEBI)
9,12,13-TriHOMEMetaboliteCHEBI:34506 (ChEBI)
9-HEPEMetaboliteCHEBI:89570 (ChEBI)
9-HETEMetaboliteCHEBI:34306 (ChEBI)
9-HODEMetaboliteCHEBI:34496 (ChEBI)
9-HpODEMetaboliteCHEBI:34498 (ChEBI)
9-oxoODEMetaboliteCHEBI:72842 (ChEBI)
AAMetaboliteCHEBI:15843 (ChEBI)
ALAMetaboliteCHEBI:27432 (ChEBI)
Ac-COX (aspirin triggered)
Alox12GeneProductP39655 (Uniprot-TrEMBL)
Alox15GeneProductP39654 (Uniprot-TrEMBL)
Alox5GeneProductP48999 (Uniprot-TrEMBL)
Alox8GeneProductO35936 (Uniprot-TrEMBL)
CYPProtein
Cbr1GeneProductP48758 (Uniprot-TrEMBL)
DGLAMetaboliteCHEBI:53486 (ChEBI)
DHAMetaboliteCHEBI:28125 (ChEBI)
Delta6 elongase
Dpep1GeneProductP31428 (Uniprot-TrEMBL)
EPAMetaboliteCHEBI:28364 (ChEBI)
Elongase
Ephx2 (sEH)GeneProductP34914 (Uniprot-TrEMBL)
Fads1GeneProductQ920L1 (Uniprot-TrEMBL)
Fads2GeneProductQ9Z0R9 (Uniprot-TrEMBL)
GPX1GeneProductP11352 (Uniprot-TrEMBL)
Ggt1GeneProductQ60928 (Uniprot-TrEMBL)
HpgdGeneProductQ8VCC1 (Uniprot-TrEMBL)
HpgdsGeneProductQ9JHF7 (Uniprot-TrEMBL)
LAMetaboliteCHEBI:17351 (ChEBI)
LTA4MetaboliteCHEBI:15651 (ChEBI)
LTB4MetaboliteCHEBI:15647 (ChEBI)
LTC4MetaboliteCHEBI:16978 (ChEBI)
LTD4MetaboliteCHEBI:28666 (ChEBI)
LTE4MetaboliteCHEBI:15650 (ChEBI)
LXA4MetaboliteCHEBI:6498 (ChEBI)
LXB4MetaboliteCHEBI:6499 (ChEBI)
Lta4hGeneProductP24527 (Uniprot-TrEMBL)
Ltc4sGeneProductQ60860 (Uniprot-TrEMBL)
Mar1MetaboliteCHEBI:165254 (ChEBI)
PD1MetaboliteCHEBI:138655 (ChEBI)
PDXMetaboliteCHEBI:138653 (ChEBI)
PGA2MetaboliteCHEBI:27820 (ChEBI)
PGB2MetaboliteCHEBI:28099 (ChEBI)
PGD2MetaboliteCHEBI:15555 (ChEBI)
PGE2MetaboliteCHEBI:15551 (ChEBI)
PGF2alphaMetaboliteCHEBI:15553 (ChEBI)
PGH2MetaboliteCHEBI:15554 (ChEBI)
PGI2MetaboliteCHEBI:15552 (ChEBI)
PGJ2MetaboliteCHEBI:27485 (ChEBI)
PGK2MetaboliteCHEBI:165341 (ChEBI)
Peroxisomal beta-oxidationPathway
PtdgsGeneProductO09114 (Uniprot-TrEMBL)
PtgesGeneProductQ9JM51 (Uniprot-TrEMBL)
PtgfsGeneProductQ9DB60 (Uniprot-TrEMBL)
PtgisGeneProductO35074 (Uniprot-TrEMBL)
Ptgs1/2GeneProductQ05769 (Uniprot-TrEMBL)
RvD1MetaboliteCHEBI:81564 (ChEBI)
RvD2MetaboliteCHEBI:81565 (ChEBI)
RvE1MetaboliteCHEBI:81559 (ChEBI)
TXA2MetaboliteCHEBI:15627 (ChEBI)
TXB2MetaboliteCHEBI:28728 (ChEBI)
Tbxas1GeneProductP36423 (Uniprot-TrEMBL)
aspirin-treated COX2Protein
sEHProteinP34914 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5140"
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