COVID-19 structural coverage map (Homo sapiens)

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332333333333333333313333333313mimicsPARP14nsp16orf3aPF-07321332 (Pfizer PAXLOVID)MPP5ACE2nsp3CMTR1PARP9MACROH2A1GDAP2EUPF1MRM2orf9b43SAQRAPOA1UBA52PAIP1MACROD1ISG15Spikensp13MACROD2TOMM70IGHMBP2UBCUBBNRP140Snsp1SLC6A19MACROH2A1mimicshijackshijacksmimicshijacks?hijackshijackshijacksUPF280Snsp5TAB1NLRP12


Description

This pathway summarizes the structural relationships (mimicking or hijacking) between COVID-19 (SARS-CoV-2) viral proteins and human proteins.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Moustaqil M, Ollivier E, Chiu HP, Van Tol S, Rudolffi-Soto P, Stevens C, Bhumkar A, Hunter DJB, Freiberg AN, Jacques D, Lee B, Sierecki E, Gambin Y; ''SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species.''; Emerg Microbes Infect, 2021 PubMed Europe PMC Scholia
  2. Ahmad B, Batool M, Ain QU, Kim MS, Choi S; ''Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations.''; Int J Mol Sci, 2021 PubMed Europe PMC Scholia
  3. O'Donoghue SI, Schafferhans A, Sikta N, Stolte C, Kaur S, Ho BK, Anderson S, Procter JB, Dallago C, Bordin N, Adcock M, Rost B; ''SARS-CoV-2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms.''; Mol Syst Biol, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124659view13:35, 18 November 2022NhungPupdate viral proteins shapes
124628view12:18, 18 November 2022NhungPchange viral proteins labels
120433view15:04, 1 December 2021EgonwFixed the data source for a complex
120375view23:21, 29 November 2021EweitzModified title
120335view18:13, 26 November 2021NhungPRemove weird anchor
120334view18:12, 26 November 2021NhungPAdjust layout
120333view18:09, 26 November 2021NhungPAdd nsp5 (3CL-Protease), its target host proteins (TAB1 & NLRP12) and the target drug
120327view15:50, 26 November 2021Mkutmonadded complexes for 40S 43S and 80S
120326view15:42, 26 November 2021MkutmonOntology Term : 'infectious disease pathway' added !
120325view15:41, 26 November 2021MkutmonOntology Term : 'COVID-19' added !
120324view15:40, 26 November 2021MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
40SComplexCPX-5223 (Complex Portal)
43SComplex
80SComplex
ACE2ProteinQ9BYF1 (Uniprot-TrEMBL)
APOA1ProteinP02647 (Uniprot-TrEMBL)
AQRProteinO60306 (Uniprot-TrEMBL)
CMTR1ProteinQ8N1G2 (Uniprot-TrEMBL)
EProteinP0DTC4 (Uniprot-TrEMBL)
GDAP2ProteinQ9NXN4 (Uniprot-TrEMBL)
IGHMBP2ProteinP38935 (Uniprot-TrEMBL)
ISG15ProteinP05161 (Uniprot-TrEMBL)
MACROD1ProteinQ9BQ69 (Uniprot-TrEMBL)
MACROD2ProteinA1Z1Q3 (Uniprot-TrEMBL)
MACROH2A1ProteinO75367 (Uniprot-TrEMBL)
MACROH2A1ProteinQ9P0M6 (Uniprot-TrEMBL)
MPP5ProteinQ8N3R9 (Uniprot-TrEMBL)
MRM2ProteinQ9UI43 (Uniprot-TrEMBL)
NLRP12ProteinP59046 (Uniprot-TrEMBL)
NRP1ProteinO14786 (Uniprot-TrEMBL)
PAIP1ProteinQ9H074 (Uniprot-TrEMBL)
PARP14ProteinQ460N5 (Uniprot-TrEMBL)
PARP9ProteinQ8IXQ6 (Uniprot-TrEMBL)
PF-07321332 (Pfizer PAXLOVID)MetaboliteDB16691 (DrugBank)
SLC6A19ProteinQ695T7 (Uniprot-TrEMBL)
SpikeProteinP0DTC2 (Uniprot-TrEMBL)
TAB1ProteinQ15750 (Uniprot-TrEMBL)
TOMM70ProteinO94826 (Uniprot-TrEMBL)
UBA52ProteinP62987 (Uniprot-TrEMBL)
UBBProteinP0CG47 (Uniprot-TrEMBL)
UBCProteinP0CG48 (Uniprot-TrEMBL)
UPF1ProteinQ92900 (Uniprot-TrEMBL)
UPF2ProteinQ9HAU5 (Uniprot-TrEMBL)
nsp13ProteinYP_009725308 (NCBI Protein)
nsp16ProteinYP_009725311 (NCBI Protein)
nsp1ProteinYP_009725297 (NCBI Protein)
nsp3ProteinYP_009725299 (NCBI Protein)
nsp5ProteinYP_009725301 (NCBI Protein)
orf3aProteinP0DTC6 (Uniprot-TrEMBL)
orf9bProteinP0DTD2 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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