Lipid metabolism in senescent cells (Homo sapiens)

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1Plasma membraneSASPSenescence-Associated Secretory PhenotypeSubset PLA2 isozymesPTGS2TP53OxylipinLipid dropletsPLA2G3PUFAsALOX5PLA2CDKN1ACell cyclearrestHRASSLCO2A1Free PUFAsCytosolPTGS2OxylipinbiosynthesisPLA2G2DPLA2G4APLA2G4CPLA2G4DPLA2G4EPLA2G4FPLA2G5PLA2G6PLA2G7PLA2G10PLA2G12APLA2G12BPLA2G1B


Description

Description of the affected lipid metabolism in senecent cells.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Wiley CD, Campisi J; ''The metabolic roots of senescence: mechanisms and opportunities for intervention.''; Nat Metab, 2021 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
120374view20:35, 29 November 2021MkutmonOntology Term : 'cellular senescence pathway' added !
120372view20:34, 29 November 2021MkutmonOntology Term : 'lipid metabolic pathway' added !
120371view20:29, 29 November 2021Mkutmonadded subset PLA2 isozymes
120369view20:20, 29 November 2021MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ALOX5GeneProductENSG00000012779 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
Cell cycle arrestPathway
Free PUFAsMetaboliteCHEBI:26208 (ChEBI)
HRASGeneProductENSG00000174775 (Ensembl)
Lipid dropletsQ573950 (Wikidata)
Oxylipin biosynthesisPathway
OxylipinMetaboliteCHEBI:61121 (ChEBI)
PLA23.1.1.4 (Enzyme Nomenclature)
PLA2G10GeneProductENSG00000069764 (Ensembl)
PLA2G12AGeneProductENSG00000123739 (Ensembl)
PLA2G12BGeneProductENSG00000138308 (Ensembl)
PLA2G1BGeneProductENSG00000170890 (Ensembl)
PLA2G2DGeneProductENSG00000117215 (Ensembl)
PLA2G3GeneProductENSG00000100078 (Ensembl)
PLA2G4AGeneProductENSG00000116711 (Ensembl)
PLA2G4CGeneProductENSG00000105499 (Ensembl)
PLA2G4DGeneProductENSG00000159337 (Ensembl)
PLA2G4EGeneProductENSG00000188089 (Ensembl)
PLA2G4FGeneProductENSG00000168907 (Ensembl)
PLA2G5GeneProductENSG00000127472 (Ensembl)
PLA2G6GeneProductENSG00000184381 (Ensembl)
PLA2G7GeneProductENSG00000146070 (Ensembl)
PTGS2GeneProductENSG00000073756 (Ensembl)
PUFAsMetaboliteCHEBI:26208 (ChEBI)
SLCO2A1GeneProductENSG00000174640 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)

Annotated Interactions

No annotated interactions

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