N-glycan biosynthesis (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none ER lumenMOGSDolicholMPDU1G10595DOLPP1PolyprenolRFT1Dolichyl diphosphateDolichyl phosphate D-mannoseFructose-6-phosphateGDP-D-mannoseDAD1STT3BSTT3ADDOSTRPN1RPN2TUSC3ALG10ALG10BGANABMAN1B1MGAT1MAN1A1MAN1A2MAN1C1MAN2A1MAN2A2MGAT2MGAT3FUT8B4GALT1B4GALT2B4GALT3ST6GAL1ST6GAL2G00171G00010G00011G10694G00012G00013G00014G00015G00019G00020G00016MGAT5MGAT5BG00021G00022MGAT4CG00017G00018ALG8ALG6ALG9ALG12ALG3G10596G10597G00007G10598G10599G00008G00006G00009Dolichyl phosphateDOLKSRD5A3DPAGT1ALG13ALG14ALG1ALG2ALG11G00001G00002G00003G00004G00005G10526G00006DPM1DPM2DPM3MPDU1Dolichyl β-D-glucosyl phosphateDolichyl phosphateALG5Dolichyl phosphateGMPPAGMPPBPMM2MPIGPIGlucose 6-phosphateMannose-6-phosphateD-mannose 1-phosphateCytoplasmGolgiG10694MGAT4BMGAT4AMGAT4DName: N-glycan biosynthesisOrganism: Homo sapiens


Description

This pathways describes the biosynthesis of N-linked (Asparagine-linked) glycans, to form glycoproteins. This process is a type of co-translational and post-translational modification and sometimes referred to as N-linked glycosylation. Glycosylation is important for many processes, including protein folding and cell-cell adhesion and immune function. This pathway was modeled based on Figure 9.3 and 9.4 from [Essentials of Glycobiology [Internet]. 3rd edition](https://www.ncbi.nlm.nih.gov/books/NBK453020/), Figure 17.1 from [Dall'Olio](https://link.springer.com/chapter/10.1007/978-981-13-2835-0_17) and [KEGG]9https://www.genome.jp/pathway/hsa005100.

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

  1. Kranz C, Denecke J, Lehrman MA, Ray S, Kienz P, Kreissel G, Sagi D, Peter-Katalinic J, Freeze HH, Schmid T, Jackowski-Dohrmann S, Harms E, Marquardt T; ''A mutation in the human MPDU1 gene causes congenital disorder of glycosylation type If (CDG-If).''; J Clin Invest, 2001 PubMed Europe PMC Scholia
  2. ''N-Glycan biosynthesis - Homo sapiens (human)''; https://www.kegg.jp/entry/pathway+hsa00510,
  3. Varki A, Cummings RD, Esko JD, et al., editors; ''Essentials of Glycobiology [Internet]. 3rd edition.''; https://www.ncbi.nlm.nih.gov/books/NBK453020/, 2017 PubMed Europe PMC Scholia
  4. Dall'Olio F; ''Glycobiology of Aging.''; Subcell Biochem, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137687
Approved
view05:14, 7 March 2025EgonwModified description
134712view12:26, 26 July 2024EweitzFix truncated text in node, standardize case
134711view12:24, 26 July 2024EweitzStandardize case
127636view10:39, 11 November 2023EgonwAdded the identifier
127082view11:06, 30 July 2023EgonwModified description
126751view13:25, 18 June 2023EgonwAdded the chapter's PubMed ID.
125991view19:15, 23 March 2023KhanspersModified description
125990view18:58, 23 March 2023Khansperslatest - updated xrefs, labels
120567view20:42, 16 December 2021KhanspersOntology Term : 'protein modification pathway' added !
120566view20:42, 16 December 2021KhanspersOntology Term : 'N-linked glycan biosynthetic pathway' added !
120565view20:39, 16 December 2021KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ALG10BGeneProductENSG00000175548 (Ensembl)
ALG10GeneProductENSG00000139133 (Ensembl)
ALG11GeneProductENSG00000253710 (Ensembl)
ALG12GeneProductENSG00000182858 (Ensembl)
ALG13GeneProductENSG00000101901 (Ensembl)
ALG14GeneProductENSG00000172339 (Ensembl)
ALG1GeneProductENSG00000033011 (Ensembl)
ALG2GeneProductENSG00000119523 (Ensembl)
ALG3GeneProductENSG00000214160 (Ensembl)
ALG5GeneProductENSG00000120697 (Ensembl)
ALG6GeneProductENSG00000088035 (Ensembl)
ALG8GeneProductENSG00000159063 (Ensembl)
ALG9GeneProductENSG00000086848 (Ensembl)
B4GALT1GeneProductENSG00000086062 (Ensembl)
B4GALT2GeneProductENSG00000117411 (Ensembl)
B4GALT3GeneProductENSG00000158850 (Ensembl)
D-mannose 1-phosphateMetaboliteCHEBI:35374 (ChEBI)
DAD1GeneProductENSG00000129562 (Ensembl)
DDOSTGeneProductENSG00000244038 (Ensembl)
DOLKGeneProductENSG00000175283 (Ensembl)
DOLPP1GeneProductENSG00000167130 (Ensembl)
DPAGT1GeneProductENSG00000172269 (Ensembl)
DPM1GeneProductENSG00000000419 (Ensembl)
DPM2GeneProductENSG00000136908 (Ensembl)
DPM3GeneProductENSG00000179085 (Ensembl)
DolicholMetaboliteCHEBI:88766 (ChEBI)
Dolichyl diphosphateMetaboliteHMDB01513 (HMDB)
Dolichyl phosphate D-mannoseMetaboliteHMDB00994 (HMDB)
Dolichyl phosphateMetaboliteCHEBI:16214 (ChEBI)
Dolichyl β-D-glucosyl phosphateMetaboliteCHEBI:15812 (ChEBI)
FUT8GeneProductENSG00000033170 (Ensembl)
Fructose-6-phosphateMetaboliteHMDB0000124 (HMDB)
G00001MetaboliteG00001 (KEGG Glycan)
G00002MetaboliteG00002 (KEGG Glycan)
G00003MetaboliteG00003 (KEGG Glycan)
G00004MetaboliteG00004 (KEGG Glycan)
G00005MetaboliteG00005 (KEGG Glycan)
G00006MetaboliteG00006 (KEGG Glycan)
G00007MetaboliteG00007 (KEGG Glycan)
G00008MetaboliteG00008 (KEGG Glycan)
G00009MetaboliteG00009 (KEGG Glycan)
G00010MetaboliteG00010 (KEGG Glycan)
G00011MetaboliteG00011 (KEGG Glycan)
G00012MetaboliteG00012 (KEGG Glycan)
G00013MetaboliteG00013 (KEGG Glycan)
G00014MetaboliteG00014 (KEGG Glycan)
G00015MetaboliteG00015 (KEGG Glycan)
G00016MetaboliteG00016 (KEGG Glycan)
G00017MetaboliteG00017 (KEGG Glycan)
G00018MetaboliteG00018 (KEGG Glycan)
G00019MetaboliteG00019 (KEGG Glycan)
G00020MetaboliteG00020 (KEGG Glycan)
G00021MetaboliteG00021 (KEGG Glycan)
G00022MetaboliteG00022 (KEGG Glycan)
G00171MetaboliteG00171 (KEGG Glycan)
G10526MetaboliteG10526 (KEGG Glycan)
G10595MetaboliteG10595 (KEGG Glycan)
G10596MetaboliteG10596 (KEGG Glycan)
G10597MetaboliteG10597 (KEGG Glycan)
G10598MetaboliteG10598 (KEGG Glycan)
G10599MetaboliteG10599 (KEGG Glycan)
G10694MetaboliteG10694 (KEGG Glycan)
GANABGeneProductENSG00000089597 (Ensembl)
GDP-D-mannoseMetaboliteCHEBI:84880 (ChEBI)
GMPPAGeneProductENSG00000144591 (Ensembl)
GMPPBGeneProductENSG00000173540 (Ensembl)
GPIGeneProductENSG00000105220 (Ensembl)
Glucose 6-phosphateMetaboliteHMDB0001401 (HMDB)
MAN1A1GeneProductENSG00000111885 (Ensembl)
MAN1A2GeneProductENSG00000198162 (Ensembl)
MAN1B1GeneProductENSG00000177239 (Ensembl)
MAN1C1GeneProductENSG00000117643 (Ensembl)
MAN2A1GeneProductENSG00000112893 (Ensembl)
MAN2A2GeneProductENSG00000196547 (Ensembl)
MGAT1GeneProductENSG00000131446 (Ensembl)
MGAT2GeneProductENSG00000168282 (Ensembl)
MGAT3GeneProductENSG00000128268 (Ensembl)
MGAT4AGeneProduct11320 (Entrez Gene)
MGAT4BGeneProductMGAT4B (HGNC)
MGAT4CGeneProductENSG00000182050 (Ensembl)
MGAT4DGeneProduct152586 (Entrez Gene)
MGAT5BGeneProduct146664 (Entrez Gene)
MGAT5GeneProductENSG00000152127 (Ensembl)
MOGSGeneProductENSG00000115275 (Ensembl)
MPDU1GeneProductENSG00000129255 (Ensembl)
MPIGeneProductENSG00000178802 (Ensembl)
Mannose-6-phosphateMetaboliteHMDB0001078 (HMDB)
PMM2GeneProductENSG00000140650 (Ensembl)
PolyprenolMetaboliteCHEBI:26199 (ChEBI)
RFT1GeneProductENSG00000163933 (Ensembl)
RPN1GeneProductENSG00000163902 (Ensembl)
RPN2GeneProductENSG00000118705 (Ensembl)
SRD5A3GeneProductENSG00000128039 (Ensembl)
ST6GAL1GeneProductENSG00000073849 (Ensembl)
ST6GAL2GeneProductENSG00000144057 (Ensembl)
STT3AGeneProductENSG00000134910 (Ensembl)
STT3BGeneProductENSG00000163527 (Ensembl)
TUSC3GeneProductENSG00000104723 (Ensembl)

Annotated Interactions

No annotated interactions

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