SARS-CoV-2 replication organelle formation (Homo sapiens)
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Description
Components of the class III PI3K complex is speculated to promote SARS-CoV-2 replication. PI3P and DFCP1 contribute to the formation of double membrane vesicles needed for viral replication. Nsp3 protein from SARS-CoV 2 stimulates the accumulation of PI3P.
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Ontology Terms
Bibliography
- Twu WI, Lee JY, Kim H, Prasad V, Cerikan B, Haselmann U, Tabata K, Bartenschlager R; ''Contribution of autophagy machinery factors to HCV and SARS-CoV-2 replication organelle formation.''; Cell Rep, 2021 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AMBRA | Protein | Q9C0C7 (Uniprot-TrEMBL) | |
ATG14 | Protein | Q6ZNE5 (Uniprot-TrEMBL) | |
Beclin-1 | Protein | Q14457 (Uniprot-TrEMBL) | |
DFCP1 | Protein | Q9HBF4 (Uniprot-TrEMBL) | |
PI3P | Metabolite | 26034 (ChEBI) | |
VPS15 | Protein | Q99570 (Uniprot-TrEMBL) | |
VPS34 | Protein | Q8NEB9 (Uniprot-TrEMBL) | |
nsp3 | Protein | YP_009725299 (NCBI Protein) | |
rep 1ab | Protein | P0DTD1 (Uniprot-TrEMBL) |
Annotated Interactions
No annotated interactions