Urotensin-II-mediated signaling pathway (Homo sapiens)

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ROSPrimary Kupffer cells Human coronary artery endothelial cells LigandRAW264.7 macrophages NADPHDownregulatedGNAQ mediated activationGene regulationLiver injury and acute liver failure DissociationKidneyMyocardial damage in atherosclerotic ratsPhosphorylationCell proliferationReactive oxygen species (ROS)ReceptorInhibitionNCF4CYBABCL2BAXCASP3CASP9NCF2NPPAHMOX1NCF1SOD2CYBBPCNACATCAMKIIAT286PLCAKT1PT308S473CYBAIFN-γ HSPA2MAPK3Y204T202MMP9IL1β Atherosclerosis and fibrosisNCF1CYBBCOL1A1THP1-Monocytes and macrophagesCREBS133UTRCOL3A1LTB4AGTR1CBPIL-6ACTA2PRKACAPCCNE1ABCA1CDK1ALOX5MMP9TNFTFPRKACANCF1IL6ICAM1p300TNF-alphaCOL4A1MMP2IFNBUrotensin-IICOL2A1NOX4TRPC4MAPK1Y187T185VCAM1CDK2ProteinPTGFB1FN1A1FM2DDIT3NCF4ESPL1UpregulatedIL1BJAK2T1007PSTAT3PT705STAT3MAPK8PY185MAPK9PT183MAPK14PNFKB1PNFKB1APERK and IL-1ß pathway activation FibroblastsTGFB1SMAD3SMAD2Proliferation,neuropathy development, vascular fibrosis and collagen synthesisTGFB1Urotensin-IIUTRMAPK1Y187T185MAPK3Y204T202RELARELAPS536NFKB1APS32IRF3Translocation from CP to NUTranslocation from CP to NUDissociationNFKB1RHOAMAPK8Y185PMAPK9PT183InflammationCardiac hypertrophyNPPBNPPAMAPK1Y187T185MAPK3T202Y204PMAPK14PY182T180Urotensin-IIUTREGFRY1068PROSPTPN11HypertrophyCHUKPS176IKBKBS180PGSK3BS9PGSK3AS21PNFKB1RELAHDAC5HDAC5PS493NFKB1ANFKB1AKT1S473PATP2A2CAMK2AT286PPLNT17PCa2+Inhibits dephosphorylation activity of PTPN11Hemodynamic effectsPIP2PI3KCAPPIP3PTENPTENPCTNNB1FN1COL1A1COL3A1Cardiac hypertrophyUrotensin-IIUTRMAPK1T185Y187MAPK3Y204T202MAPK8PY185MAPK9PT183AKT1S473PPI3KCAPCYBBFSCN1ROSNCF1NADPH++H+O2Cell invasion and migrationCY to PMNFKB1PNFKB1APDissociationNFKB1CancerUrotensin-IIUTRCREBCa2+IP3Endoplasmic reticulam stressEpithelial-mesenchymal transitionCOL4A1FN1Aristoiochic acid nephropathyProliferationExtracellular matric protein accumulationTranslocation from CP to NUGANQTranslocation from CP to NUTranslocation from nucleus(NU) to cytoplasm (CP)RELACardiac hypertrophyMyocardial fibrosis and hypertrophyInhibition of PTEN leads to activation of AKT1/GSK3BIRF3IL1β TNF-alphaPromote the release of inflammatory cytokinsDissociationKidney diseaseMAPK14PT180Y182TRPC4 channel-mediated store-operated Ca2+ entry (SOCE) and sequential activation of CaMKIIPRKACAProduction against ischemic reperfusion injuryTranslocation from CP to NUTranslocation from NU to CPTranslocation from cytoplasm (CP) to nucleus (NU)ROS mediated activationTranslocation from cytoplasm (CP) to plasma membrane (PM)ActivationFigure legend


Description

Schematic representation of Urotensin-II-mediated signaling pathway

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Bibliography

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  1. Bianca Rd, Mitidieri E, Fusco F, D'Aiuto E, Grieco P, Novellino E, Imbimbo C, Mirone V, Cirino G, Sorrentino R; ''Endogenous urotensin II selectively modulates erectile function through eNOS.''; PLoS One, 2012 PubMed Europe PMC Scholia
  2. Segain JP, Rolli-Derkinderen M, Gervois N, Raingeard de la Blétière D, Loirand G, Pacaud P; ''Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes.''; J Immunol, 2007 PubMed Europe PMC Scholia
  3. Gong H, Chen Z, Zhang X, Li Y, Zhang J, Chen Y, Ding Y, Zhang G, Yang C, Zhu Y, Zou Y; ''Urotensin II Protects Cardiomyocytes from Apoptosis Induced by Oxidative Stress through the CSE/H2S Pathway.''; Int J Mol Sci, 2015 PubMed Europe PMC Scholia
  4. Liang DY, Liu LM, Ye CG, Zhao L, Yu FP, Gao DY, Wang YY, Yang ZW; ''Inhibition of UII/UTR system relieves acute inflammation of liver through preventing activation of NF-κB pathway in ALF mice.''; PLoS One, 2014 PubMed Europe PMC Scholia
  5. Zhou CH, Wan YY, Chu XH, Song Z, Xing SH, Wu YQ, Yin XX; ''Urotensin II contributes to the formation of lung adenocarcinoma inflammatory microenvironment through the NF-κB pathway in tumor-bearing nude mice.''; Oncol Lett, 2012 PubMed Europe PMC Scholia
  6. Trebicka J, Leifeld L, Hennenberg M, Biecker E, Eckhardt A, Fischer N, Pröbsting AS, Clemens C, Lammert F, Sauerbruch T, Heller J; ''Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats.''; Hepatology, 2008 PubMed Europe PMC Scholia
  7. Diebold I, Petry A, Burger M, Hess J, Görlach A; ''NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II.''; Mol Biol Cell, 2011 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126484view16:57, 8 May 2023Khanspersremove labels as identifiers from xrefs
126369view17:47, 25 April 2023EgonwNot a mim-conversion
126326view20:57, 21 April 2023KhanspersOntology Term : 'signaling pathway' added !
126325view20:21, 21 April 2023Khanspersxrefs
126315view23:46, 20 April 2023Khanspersxrefs
126314view23:10, 20 April 2023Khanspersmore xrefs
126313view21:08, 20 April 2023Khanspersmore xrefs
126287view05:24, 20 April 2023Khanspersmore xrefs
126260view22:29, 18 April 2023Khanspersadded xrefs to first box
126259view22:06, 18 April 2023Khanspersconnected interactions, converted to graphical line where appropriate
122561view08:39, 16 April 2022EgonwRemove gene symbols which are not valid identifiers in the stated data sources
120968view06:29, 4 February 2022Keshav
120925view19:20, 31 January 2022EgonwFixed the data sources for UniProt identifiers
120900view08:22, 29 January 2022KeshavModified title
120899view08:20, 29 January 2022KeshavNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
A1FM2GeneProduct84883 (Entrez Gene)
ABCA1GeneProduct19 (Entrez Gene)
ACTA2GeneProduct59 (Entrez Gene)
AGTR1GeneProduct185 (Entrez Gene)
AKT1ProteinP31749 (Uniprot-TrEMBL)
ALOX5GeneProduct240 (Entrez Gene)
ATP2A2Protein
BAXGeneProduct581 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
CAMK2AProteinQ7LDD5 (Uniprot-TrEMBL)
CAMKIIAGeneProductQ7LDD5 (Uniprot-TrEMBL)
CASP3GeneProduct836 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CATGeneProduct
CBPGeneProduct1387 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CDK1GeneProduct983 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CHUKProteinO15111 (Uniprot-TrEMBL)
COL1A1GeneProduct1277 (Entrez Gene)
COL2A1GeneProduct1280 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
COL4A1GeneProduct1277 (Entrez Gene)
CREBGeneProduct
CTNNB1GeneProduct1499 (Entrez Gene)
CYBAGeneProduct1535 (Entrez Gene)
CYBBGeneProduct1536 (Entrez Gene)
DDIT3GeneProduct1649 (Entrez Gene)
EGFRProteinP00533 (Uniprot-TrEMBL)
ESPL1GeneProduct9700 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
FSCN1GeneProduct6624 (Entrez Gene)
GANQProtein
GSK3AProteinP49840 (Uniprot-TrEMBL)
GSK3BProteinP49841 (Uniprot-TrEMBL)
HDAC5ProteinQ9UQL6 (Uniprot-TrEMBL)
HMOX1GeneProduct3162 (Entrez Gene)
HSPA2GeneProduct3306 (Entrez Gene)
ICAM1GeneProduct3383 (Entrez Gene)
IFN-γ GeneProduct
IFNBGeneProduct
IKBKBProteinO14920 (Uniprot-TrEMBL)
IL-6GeneProduct3569 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL1β GeneProduct
IL6GeneProduct3569 (Entrez Gene)
IRF3GeneProduct3661 (Entrez Gene)
JAK2ProteinO60674 (Uniprot-TrEMBL)
LTB4GeneProduct
MAPK14ProteinQ16539 (Uniprot-TrEMBL)
MAPK14Protein
MAPK1ProteinP28482 (Uniprot-TrEMBL)
MAPK3ProteinP27361 (Uniprot-TrEMBL)
MAPK8ProteinP45983 (Uniprot-TrEMBL)
MAPK9ProteinP45984 (Uniprot-TrEMBL)
MMP2GeneProduct4313 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
NCF1GeneProduct653361 (Entrez Gene)
NCF2GeneProduct4688 (Entrez Gene)
NCF4GeneProduct4689 (Entrez Gene)
NFKB1AProteinNFKB1A (HGNC)
NFKB1AProtein
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NOX4GeneProduct50507 (Entrez Gene)
NPPAGeneProduct
NPPAGeneProduct4878 (Entrez Gene)
NPPBGeneProduct4879 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
PI3KCAProtein
PIP2Protein
PIP3Protein
PLCGeneProduct
PLNProteinP26678 (Uniprot-TrEMBL)
PRKACAGeneProduct5566 (Entrez Gene)
PRKACAProteinP17612 (Uniprot-TrEMBL)
PTENGeneProduct5728 (Entrez Gene)
PTENProteinP60484 (Uniprot-TrEMBL)
PTPN11ProteinQ06124 (Uniprot-TrEMBL)
ProteinGeneProduct
RELAProteinQ04206 (Uniprot-TrEMBL)
RHOAProteinP61586 (Uniprot-TrEMBL)
SMAD2GeneProductSMAD2 (HGNC)
SMAD3GeneProduct4088 (Entrez Gene)
SOD2GeneProduct
STAT3Protein6774 (Entrez Gene)
STAT3ProteinP40763 (Uniprot-TrEMBL)
TFGeneProduct
TGFB1GeneProduct7040 (Entrez Gene)
TNF-alphaGeneProduct
TNFGeneProduct7124 (Entrez Gene)
TRPC4ProteinQ9UBN4 (Uniprot-TrEMBL)
UTRProteinQ9UKP6 (Uniprot-TrEMBL)
Urotensin-IIProteinO95399 (Uniprot-TrEMBL)
VCAM1GeneProduct7412 (Entrez Gene)
p300GeneProduct2033 (Entrez Gene)

Annotated Interactions

No annotated interactions

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