N-glycan biosynthesis (Ovis aries)
From WikiPathways
Description
Broadly speaking, the role of protein-linked glycans is to function as specific binding determinants or modulators of the proteins that they are attached to.
View original pathway at https://www.genome.jp/kegg-bin/show_pathway?oas00510 .Quality Tags
Ontology Terms
Saving...Bibliography
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- Oriol R, Martinez-Duncker I, Chantret I, Mollicone R, Codogno P; ''Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate.''; Mol Biol Evol, 2002 PubMed Europe PMC Scholia
- Roth J; ''Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein quality control, and cell interactions.''; Chem Rev, 2002 PubMed Europe PMC Scholia
- Breitling J, Aebi M; ''N-linked protein glycosylation in the endoplasmic reticulum.''; Cold Spring Harb Perspect Biol, 2013 PubMed Europe PMC Scholia
- Cumming DA; ''Chapter 14: Pathways and functions of mammalian protein glycosylation''; Gene Transfer and Expression in Mammalian Cells, 2003 PubMed Europe PMC Scholia
- Cipollo JF, Trimble RB, Chi JH, Yan Q, Dean N; ''The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
- Thiel C, Schwarz M, Peng J, Grzmil M, Hasilik M, Braulke T, Kohlschütter A, von Figura K, Lehle L, Körner C; ''A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
- O'Reilly MK, Zhang G, Imperiali B; ''In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis.''; Biochemistry, 2006 PubMed Europe PMC Scholia
- Frank CG, Aebi M; ''ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis.''; Glycobiology, 2005 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| N,N'-Chitobiosyldiphosphodolichol | Metabolite | G00002 (KEGG Glycan)  | |
| (Gal)2 (GlcNAc)4 (LFuc)1 (Man)3 (Asn)1 | Metabolite | G00017 (KEGG Glycan) | |
| (Gal)2 (GlcNAc)4 (LFuc)1 (Man)3 (Neu5Ac)2 (Asn)1 | Metabolite | G00018 (KEGG Glycan) | |
| (Glc)1 (GlcNAc)2 (Man)9 (Asn)1 | Metabolite | G00010 (KEGG Glycan) | |
| (Glc)1 (GlcNAc)2 (Man)9 (PP-Dol)1 | Metabolite | G10598 (KEGG Glycan) | |
| (Glc)2 (GlcNAc)2 (Man)9 (Asn)1 | Metabolite | G00171 (KEGG Glycan) | |
| (Glc)2 (GlcNAc)2 (Man)9 (PP-Dol)1 | Metabolite | G10599 (KEGG Glycan) | |
| (Glc)3 (GlcNAc)2 (Man)9 (Asn)1 | Metabolite | G00009 (KEGG Glycan) | |
| (Glc)3 (GlcNAc)2 (Man)9 (PP-Dol)1 | Metabolite | G00008 (KEGG Glycan) | |
| (GlcNAc)2 (Man)2 (PP-Dol)1 | Metabolite | G00004 (KEGG Glycan) | Sometimes referred to as: - Alpha-D-Mannosyl-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol |
| (GlcNAc)2 (Man)3 (PP-Dol)1 | Metabolite | G00005 (KEGG Glycan) | |
| (GlcNAc)2 (Man)4 (PP-Dol)1 | Metabolite | G10526 (KEGG Glycan) | |
| (GlcNAc)2 (Man)5 (Asn)1 | Metabolite | G00012 (KEGG Glycan) | |
| (GlcNAc)2 (Man)5 (PP-Dol)1 | Metabolite | G00006 (KEGG Glycan) | Sometimes referred to as: - (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol |
| (GlcNAc)2 (Man)6 (PP-Dol)1 | Metabolite | G10595 (KEGG Glycan) | |
| (GlcNAc)2 (Man)7 (PP-Dol)1 | Metabolite | G10596 (KEGG Glycan) | |
| (GlcNAc)2 (Man)8 (Asn)1 | Metabolite | G10694 (KEGG Glycan) | |
| (GlcNAc)2 (Man)8 (PP-Dol)1 | Metabolite | G10597 (KEGG Glycan) | |
| (GlcNAc)2 (Man)9 (Asn)1 | Metabolite | G00011 (KEGG Glycan) | |
| (GlcNAc)2 (Man)9 (PP-Dol)1 | Metabolite | G00007 (KEGG Glycan) | |
| (GlcNAc)3 (Man)3 (Asn)1 | Metabolite | G00014 (KEGG Glycan) | |
| (GlcNAc)3 (Man)5 (Asn)1 | Metabolite | G00013 (KEGG Glycan) | |
| (GlcNAc)4 (LFuc)1 (Man)3 (Asn)1 | Metabolite | G00016 (KEGG Glycan) | |
| (GlcNAc)4 (Man)3 (Asn)1 | Metabolite | G00015 (KEGG Glycan) | |
| (GlcNAc)5 (Man)3 (Asn)1 | Metabolite | G00019 (KEGG Glycan) | |
| (GlcNAc)5 (Man)3 (Asn)1 | Metabolite | G00020 (KEGG Glycan) | |
| (GlcNAc)6 (Man)3 (Asn)1 | Metabolite | G00021 (KEGG Glycan) | |
| (GlcNAc)7 (Man)3 (Asn)1 | Metabolite | G00022 (KEGG Glycan) | |
| ALG10 | GeneProduct | ENSOARG00000019292 (Ensembl) | Sometimes referred to as:
- dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase - alpha-1,2-glucosyltransferase - ALG10 alpha-1,2-glucosyltransferase |
| ALG11 | GeneProduct | XP_004012140 (NCBI Protein) | Sometimes referred to as:
- GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase - Alpha-1,2-mannosyltransferase |
| ALG12 | GeneProduct | ENSOARG00000019629 (Ensembl) | Sometimes referred to as:
- Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase - Alpha-1,6-mannosyltransferase - ALG12 alpha-1,6-mannosyltransferase |
| ALG13 | GeneProduct | ENSOARG00000017633 (Ensembl) | Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X1. |
| ALG14 | GeneProduct | XP_027828046 (NCBI Protein) | Sometimes referred to as:
- UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X1 - beta-1,4-N-acetylglucosaminyltransferase |
| ALG1 | GeneProduct | ENSOARG00000005002 (Ensembl) | Sometimes referred to as:
- chitobiosyldiphosphodolichol beta-mannosyltransferase isoform X1 - chitobiosyldiphosphodolichol beta-mannosyltransferase |
| ALG2 | GeneProduct | XP_004004274 (NCBI Protein) | Sometimes referred to as:
- alpha-1,3/1,6-mannosyltransferase ALG2 - alpha-1,3/alpha-1,6-mannosyltransferase |
| ALG3 | GeneProduct | ENSOARG00000020606 (Ensembl) | Sometimes referred to as:
- Alpha-1,3-mannosyltransferase - Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase - ALG3 alpha-1,3- mannosyltransferase |
| ALG5 | GeneProduct | ENSOARG00000010275 (Ensembl) | Sometimes referred to as:
- ALG5 dolichyl-phosphate beta-glucosyltransferase - Dolichyl-phosphate beta-glucosyltransferase |
| ALG6 | GeneProduct | ENSOARG00000009650 (Ensembl) | Sometimes referred to as:
- ALG6 alpha-1,3-glucosyltransferase - Alpha-1,3-glucosyltransferase |
| ALG8 | GeneProduct | ENSOARG00000006601 (Ensembl) | Sometimes referred to as:
- Alpha-1,3-glucosyltransferase - ALG8 alpha-1,3-glucosyltransferase |
| ALG9 | GeneProduct | ENSOARG00000014873 (Ensembl) | |
| B4GALT1 | GeneProduct | ENSOARG00000009544 (Ensembl) | Sometimes referred to as: - Beta-1,4-galactosyltransferase 1 |
| B4GALT3 | GeneProduct | ENSOARG00000009668 (Ensembl) | Sometimes referred to as: - Beta-1,4-galactosyltransferase 3 |
| Beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol | Metabolite | G00003 (KEGG Glycan) | |
| DAD1 | GeneProduct | ENSOARG00000019440 (Ensembl) | Sometimes referred to as:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 - Oligosaccharyltransferase complex subunit epsilon - Defender against cell death 1 |
| DDOS | GeneProduct | ENSOARG00000009017 (Ensembl) | Sometimes referred to as:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit |
| DMP2 | Protein | ENSOARG00000011136 (Ensembl) | Sometimes referred to as:
- Dolichol phosphate-mannose biosynthesis regulatory protein - Dolichyl-phosphate mannosyltransferase subunit 2 |
| DMP3 | Protein | ENSOARG00000006665 (Ensembl) | Sometimes referred to as: - Dolichol-phosphate mannosyltransferase subunit 3 |
| DPAGT1 | Protein | ENSOARG00000013201 (Ensembl) | Sometimes referred to as:
- Dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 - UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X1 - ALG7 (=gene) |
| DPM1 | Protein | ENSOARG00000013988 (Ensembl) | Sometimes referred to as: - Dolichol-phosphate mannosyltransferase subunit 1 |
| Ditrans,polycis-polyprenol | Metabolite | CHEBI:67132 (ChEBI) | In literature also simply refered to as polyprenol. |
| Dolichol Kinase | Protein | ENSOARG00000019081 (Ensembl) | Sometimes referred to as: - DOLK |
| Dolichol | Metabolite | CHEBI:16091 (ChEBI) | |
| Dolichyl Beta-D-Glucosyl Phosphate | Metabolite | LMPR03080014 (LIPID MAPS) | Sometimes referred to as:
- α-(3-methylbut-2-en-1-yl)-�‰-{4-[(β-D-glucopyranosyloxy)(hydroxy)phosphoryloxy]-2-methylbutyl}poly[(2E)-2-methylbut-2-ene-1,4-diyl] - Dolichyl beta-D-glucosyl phosphate |
| Dolichyl Diphosphate | Metabolite | LMPR03090023 (LIPID MAPS) | Sometimes referred to as: - Dolichol diphosphate |
| Dolichyl Phosphate | Metabolite | LMPR03080015 (LIPID MAPS) | Sometimes referred to as:
- Dolichol phosphate - Dolicholmonophosphate |
| Dolichyl phosphate D-mannose | Metabolite | 6598 (PubChem-substance) | Sometimes referred to as:
- Dolichyl phosphate D-mannose - Dolichyl D-mannosyl phosphate - Dolichyl beta-D-mannosyl phosphate |
| Dolichyldiphosphatase | Protein | XP_027822123 (NCBI Protein) | Sometimes referred to as:
- DOLPP1 - Dolichyldiphosphatase 1 isoform X5 |
| FUT8 | GeneProduct | ENSOARG00000021160 (Ensembl) | Sometimes referred to as:
- Fucosyltransferase 8 - Alpha-(1,6)-fucosyltransferase |
| Fructose and Mannose Metabolism | Pathway | oas00051 (KEGG Pathway) | This pathway can be found in the Kegg database. Here, one can manually adjust the general-species pathway to the Ovis Aries pathway. |
| GANAB | GeneProduct | ENSOARG00000015910 (Ensembl) | Sometimes referred to as:
- Neutral alpha-glucosidase AB isoform X1 - Mannosyl-oligosaccharide alpha-1,3-glucosidase - Glucosidase II alpha subunit |
| GDP-mannose | Metabolite | C00096 (KEGG Compound) | Sometimes referred to as:
- GDP mannose - GDP-mannose - GDP-alpha-D-mannose - Guanosine diphosphate mannose - The α-anomer of GDP-D-mannose |
| Glycosaminoglycan biosynthesis - Keratan sulfate | Pathway | oas00533 (KEGG Pathway) | |
| L-Asparagine | Metabolite | CHEBI:17196 (ChEBI) | Sometimes referred to as "Asn-X-Ser/Thr" because oligosaccharyltransferase (OST) selects the Asn-X-Ser/Thr consensus sequence on polypeptide chains |
| LOC114113140 | GeneProduct | A0A6P7DPQ4 (Uniprot-TrEMBL) | Sometimes referred to as:
- Sialyltransferase 1 - Beta-galactoside alpha-2,6-sialyltransferase 1-like |
| MAN1A1 | GeneProduct | ENSOARG00000008408 (Ensembl) | Sometimes referred to as:
- Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA - Mannosyl-oligosaccharide alpha-1,2-mannosidase - Mannosidase alpha class 1A member 1 - Alpha-1,2-Mannosidase |
| MAN1A2 | GeneProduct | ENSOARG00000020315 (Ensembl) | Sometimes referred to as:
- Mannosidase alpha class 1A member 2 - Alpha-1,2-Mannosidase - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB - Mannosyl-oligosaccharide alpha-1,2-mannosidase |
| MAN1B1 | GeneProduct | A0A6P7DSV8 (Uniprot-TrEMBL) | Sometimes referred to as:
- Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1 - Endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase - Alpha-1,2-Mannosidase |
| MAN1C1 | GeneProduct | ENSOARG00000005906 (Ensembl) | Sometimes referred to as:
- Mannosidase alpha class 1C member 1 - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform X1 - Alpha-1,2-Mannosidase |
| MAN2A2 | GeneProduct | ENSOARG00000012575 (Ensembl) | Sometimes referred to as:
- Alpha-mannosidase II - Alpha-mannosidase 2x isoform X1 - Mannosidase alpha class 2A member 2 |
| MGAT1 | GeneProduct | ENSOARG00000016716 (Ensembl) | Sometimes referred to as:
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase - Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase |
| MGAT2 | GeneProduct | ENSOARG00000000832 (Ensembl) | Sometimes referred to as:
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase - Alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase |
| MGAT3 | GeneProduct | A0A6P7DZW7 (Uniprot-TrEMBL) | Sometimes referred to as:
- Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase - Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase isoform X3 |
| MGAT4A | GeneProduct | ENSOARG00000013496 (Ensembl) | Sometimes referred to as:
- alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X2 - alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A |
| MGAT4B | GeneProduct | ENSOARG00000002936 (Ensembl) | Sometimes referred to as:
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B isoform X1 - Alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B |
| MGAT4C | GeneProduct | A0A6P7DXD1 (Uniprot-TrEMBL) | Sometimes referred to as:
- MGAT4 family member C - Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C - Alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase C |
| MGAT4D | GeneProduct | ENSOARG00000012558 (Ensembl) | Sometimes referred to as:
- MGAT4 family member D - alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B - alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D |
| MGAT5B | GeneProduct | ENSOARG00000006412 (Ensembl) | Sometimes referred to as:
- Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform X1 - Mannosyl alpha-1,6-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B - alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B |
| MGAT5 | GeneProduct | ENSOARG00000011436 (Ensembl) | Sometimes referred to as:
- Alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase - Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A |
| MOGS | GeneProduct | ENSOARG00000012692 (Ensembl) | Sometimes referred to as: - Mannosyl-oligosaccharide glucosidase |
| N-Acetyl-D-glucosaminyldiphosphodolichol | Metabolite | G00001 (KEGG Glycan) | |
| Polyprenol Reductase | Protein | ENSOARG00000001390 (Ensembl) | Also referred to as:
- Steroid 5 alpha-reductase 3 - 3-oxo-5-alpha-steroid 4-dehydrogenase 3 - polyprenol reductase isoform X3 From gene: - SRD5A3 |
| RPN1 | GeneProduct | XP_027813657 (NCBI Protein) | Sometimes referred to as:
- Ribophorin I - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 - Oligosaccharyltransferase complex subunit alpha |
| RPN2 | GeneProduct | ENSOARG00000017801 (Ensembl) | Sometimes referred to as:
- Ribophorin II - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X2 - Oligosaccharyltransferase complex subunit delta |
| ST6GAL1 | GeneProduct | ENSOARG00000020506 (Ensembl) | Sometimes referred to as:
- Beta-galactoside alpha-2,6-sialyltransferase 1 - ST6 beta-galactoside alpha-2,6-sialyltransferase 1 |
| ST6GAL2 | GeneProduct | A0A6P7DVZ4 (Uniprot-TrEMBL) | Sometimes referred to as:
- Beta-galactoside alpha-2,6-sialyltransferase 2 - Beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1 |
| STT3A | GeneProduct | ENSOARG00000011533 (Ensembl) | Sometimes referred to as:
- STT3 oligosaccharyltransferase complex catalytic subunit A - dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform X3 - Dolichyl-diphosphooligosaccharide--protein glycotransferase |
| STT3B | GeneProduct | ENSOARG00000014854 (Ensembl) | Sometimes referred to as:
- STT3 oligosaccharyltransferase complex catalytic subunit B - dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B - Dolichyl-diphosphooligosaccharide--protein glycotransferase |
| TUSC3 | GeneProduct | ENSOARG00000009678 (Ensembl) | Sometimes referred to as:
- Tumor suppressor candidate 3 isoform X4 - Oligosaccharyltransferase complex subunit gamma |
| Terpenoid Backbone Biosynthesis | Pathway | oas00900 (KEGG Pathway) | This pathway can be found in the Kegg database. Here, one can manually adjust the general-species pathway to the Ovis Aries pathway. |
| Various types of N-glycan biosynthesis | Pathway | oas00513 (KEGG Pathway) | This pathway can be found in the Kegg database. Here, one can manually adjust the general-species pathway to the Ovis Aries pathway. |
Annotated Interactions
No annotated interactions
