Amino acid metabolism in triple-negative breast cancer cells (Homo sapiens)

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25serineglycinepyruvateSHMTglutamineAminotransferaseCB-839PHGDHphosphohydroxypyruvateGLUT1phosphoserineSLC1A5SLC7A11PSPHmalatecystinesulfasalazineGLSreduced glutathioneGLSglutamine glucosePSAT1NH3Serine metabolismglucoseGlutamine metabolism3-phospho-glycerateα-ketoglutarateglutamate1, 43Glycine metabolismcystineglutamateglutamateoxaloacetatecitrateglutamateα-ketoglutarate


Description

Amino acid metabolism in triple-negative breast cancer cells. The glutamine, serine and glycine metabolic pathways are significantly upregulated. The upregulated expression of key genes within the glutamine, serine and glycine metabolic pathways have also been observed in triple-negative breast cancer cells

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Ontology Terms

 

Bibliography

  1. Bhutia YD, Babu E, Ramachandran S, Ganapathy V; ''Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs.''; Cancer Res, 2015 PubMed Europe PMC Scholia
  2. Wang Z, Jiang Q, Dong C; ''Metabolic reprogramming in triple-negative breast cancer.''; Cancer Biol Med, 2020 PubMed Europe PMC Scholia
  3. Christiaan F. Labuschagne, Niels J.F. van den Broek, Gillian M. Mackay, Karen H. Vousden, Oliver D.K. Maddocks; ''Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells''; https://doi.org/10.1016/j.celrep.2014.04.045, 2014 DOI Scholia
  4. Kung HN, Marks JR, Chi JT; ''Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.''; PLoS Genet, 2011 PubMed Europe PMC Scholia
  5. Kim SK, Jung WH, Koo JS; ''Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes.''; PLoS One, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129313view13:53, 26 March 2024MkutmonOntology Term : 'cancer pathway' added !
129312view13:52, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
126591view07:38, 6 June 2023Mkutmonupdate labels
126590view07:29, 6 June 2023Mkutmonlayout updates
124889view14:03, 29 December 2022EgonwManually added the DOI identifier as identifier too
122577view13:37, 17 April 2022EgonwMade three pathways clickable
122408view09:21, 30 March 2022Andraadded datanode identifiers
122406view09:12, 30 March 2022Andraadded metabolite identifiers
122328view10:22, 18 March 2022Andraadded identifiers
122327view10:15, 18 March 2022Andraadded references
122323view22:59, 17 March 2022AndraOntology Term : 'triple-receptor negative breast cancer' added !
122322view22:58, 17 March 2022AndraOntology Term : 'glutamine metabolic pathway' added !
122321view22:57, 17 March 2022AndraOntology Term : 'glycine metabolic pathway' added !
122320view22:56, 17 March 2022AndraOntology Term : 'serine metabolic pathway' added !
122319view22:53, 17 March 2022AndraNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
3-phospho-glycerateMetabolite724 (PubChem-compound)
AminotransferaseGeneProductPF00155 (Pfam)
CB-839MetaboliteQ27075751 (Wikidata)
GLSGeneProduct2744 (Entrez Gene)
GLUT1GeneProduct6513 (Entrez Gene)
Glutamine metabolismPathwayR-HSA-8964539 (Reactome)
Glycine metabolismPathwayWP4688 (WikiPathways)
NH3Metabolite222 (PubChem-compound)
PHGDHGeneProduct26227 (Entrez Gene)
PSAT1GeneProduct29968 (Entrez Gene)
PSPHGeneProduct5723 (Entrez Gene)
SHMTGeneProduct2.1.2.1 (Enzyme Nomenclature)
SLC1A5GeneProduct6510 (Entrez Gene)
SLC7A11GeneProduct23657 (Entrez Gene)
Serine metabolismPathwayWP4688 (WikiPathways)
citrateMetabolite31348 (PubChem-compound)
cystineMetabolite595 (PubChem-compound)
glucoseMetaboliteQ37525 (Wikidata)
glutamateMetabolite33032 (PubChem-compound)
glutamine Metabolite5961 (PubChem-compound)
glutamineMetabolite5961 (PubChem-compound)
glycineMetabolite753 (PubChem-compound)
malateMetabolite160434 (PubChem-compound)
oxaloacetateMetabolite970 (PubChem-compound)
phosphohydroxypyruvateMetabolite5460375 (PubChem-compound)
phosphoserineMetabolite68841 (PubChem-compound)
pyruvateMetabolite107735 (PubChem-compound)
reduced glutathioneMetabolite124886 (PubChem-compound)
serineMetabolite5951 (PubChem-compound)
sulfasalazineMetabolite5339 (PubChem-compound)
α-ketoglutarateMetabolite51 (PubChem-compound)

Annotated Interactions

No annotated interactions

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