2q13 copy number variation syndrome (Homo sapiens)

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Cell4747474747Extracelullar space7, 135524629, 4352421211, 35411473120495440473, 23, 32, 426, 22, 25, 37, 55458, 15, 24525211282, 10, 17, 36, 5052144752716, 5152474352518, 30, 34, 38, 39544, 5333, 4847EndosomeExtracellularPeroxisomeAGExact function unknownExact function unknownMitochondrialprotein importRAC1ApoptosisIL36RNBCL2L11Peroxisomal lipid metabolismPOLR1BNa+POLR2KCHCHD5immature T cellproliferation in thymusSOCS3extracellular matrixproteinsIL36Bmitotic spindleassemblyMIR4771-1ARF6GAS6ACOXLPOLR1FPOLR1HodontoblastPOLR1AIL1F10ZC3H6IL1RNMAPK1FADtranscription elongation factor complexRN7SL297PIL1BTTLRPL5P9APC/C complexRNU6-1180PARL14HMGN2P23GDPactin cytoskeleton reorganization IL36AANAPC1MIR4435-1POLR1GGRB2IL-1 signaling pathwayAnti-inflammatorycytokinesIL2SLC20A1ACOXLNT5DC4RNA pol I holoenzymemacrophageIL6IL36GPOLR1BmicrotubulePOLR2LPLCG2GATA3IL1RAPCXCL13STAT1innate immune responsePOLR1CIL1APOLR2ECSF2IL36RNPisnRNA transcription by RNA polymerase IIRegulation of mitotic cell cycleFBLN7Carboxyterminalpost-translationalmodifications of tubulinIL1RAPPOLR2HCSF1IL1R1IL23ACKAP2LPSD4IL1RL2SLC20A1TMEM87BEpithelial inflammatory responsePOLR1DMIR4435-1HGRGPD8RPS14P4IL37dendritic cellPOLR1ETULP1Canonical NF-kB pathwayPOLR2FMIR4435-2SOCS1LGALS3MAPK cascadeRNA Polymerase I TranscriptionPTK2MERTKMIR4771-2ZC3H8Teeth developmentimmunomodulationPTK2MAPK1RAC121Na+Pi555555512269B cell proliferation19ARF6ARL14proteinschr2:111,490,150chr2:96,097,383713LegendTranslocationGene ProductMetaboliteRNA geneMIM-stimulation of an enzyme or a gene leading to its activation or expressionData node for a micro RNA or another RNA geneData node for a pathwayMIM-inhibition of a compound's function or a processMIM-catalysis of a compound by an enzymePathwayComplexMIM-transcription-translation of a geneData node for a metaboliteDashed line indicates unclear mechanismof interaction/unclear intermediatesData node for a gene or its productMIM-conversion of a compound to anotherMIM-binding of a compound to anotherData node for a pseudo geneproteinsPhosphorylated proteinPseudogeneGTPGDPGDPGTPGTPNEUROPATHOLOGY6, 22, 25, 37, 55Data node for associated neuropathologyFILIPPI SYNDROME; FLPIS


Description

The 2q13 copy number variation syndrome can result in the loss of up to 25 protein-coding genes. Patients with 2q13 deletions and duplications had abnormal head size and dysmorphic features (DOI: 10.1002/ajmg.a.37269). 2q13 duplications also caused developmental delay. The abnormal head size in 2q13 could be explained by the changes in FBLN7 gene (DOI: 10.1002/ajmg.a.37269). At the same time, neuropsychiatric impairment in 2q13 may be associated with BCL2L11, ANAPC1, SLC1A1 and MERTK alterations (DOI: 10.1002/ajmg.b.32236).

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Bibliography

View all...
  1. Hussain MS, Battaglia A, Szczepanski S, Kaygusuz E, Toliat MR, Sakakibara S, Altmüller J, Thiele H, Nürnberg G, Moosa S, Yigit G, Beleggia F, Tinschert S, Clayton-Smith J, Vasudevan P, Urquhart JE, Donnai D, Fryer A, Percin F, Brancati F, Dobbie A, Smigiel R, Gillessen-Kaesbach G, Wollnik B, Noegel AA, Newman WG, Nürnberg P; ''Mutations in CKAP2L, the human homolog of the mouse Radmis gene, cause Filippi syndrome.''; Am J Hum Genet, 2014 PubMed Europe PMC Scholia
  2. Pilsl M, Crucifix C, Papai G, Krupp F, Steinbauer R, Griesenbeck J, Milkereit P, Tschochner H, Schultz P; ''Structure of the initiation-competent RNA polymerase I and its implication for transcription.''; Nat Commun, 2016 PubMed Europe PMC Scholia
  3. O'Reilly D, Kuznetsova OV, Laitem C, Zaborowska J, Dienstbier M, Murphy S; ''Human snRNA genes use polyadenylation factors to promote efficient transcription termination.''; Nucleic Acids Res, 2014 PubMed Europe PMC Scholia
  4. Jackson TR, Kearns BG, Theibert AB; ''Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling.''; Trends Biochem Sci, 2000 PubMed Europe PMC Scholia
  5. Zhou L, Todorovic V; ''Interleukin-36: Structure, Signaling and Function.''; Adv Exp Med Biol, 2021 PubMed Europe PMC Scholia
  6. Bøttger P, Hede SE, Grunnet M, Høyer B, Klaerke DA, Pedersen L; ''Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.''; Am J Physiol Cell Physiol, 2006 PubMed Europe PMC Scholia
  7. Costain G, Lionel AC, Fu F, Stavropoulos DJ, Gazzellone MJ, Marshall CR, Scherer SW, Bassett AS; ''Adult neuropsychiatric expression and familial segregation of 2q13 duplications.''; Am J Med Genet B Neuropsychiatr Genet, 2014 PubMed Europe PMC Scholia
  8. Jin L, Williamson A, Banerjee S, Philipp I, Rape M; ''Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.''; Cell, 2008 PubMed Europe PMC Scholia
  9. Caberoy NB, Alvarado G, Bigcas JL, Li W; ''Galectin-3 is a new MerTK-specific eat-me signal.''; J Cell Physiol, 2012 PubMed Europe PMC Scholia
  10. Panov KI, Panova TB, Gadal O, Nishiyama K, Saito T, Russell J, Zomerdijk JC; ''RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor.''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  11. Esmaeilzadeh A, Bahmaie N, Nouri E, Hajkazemi MJ, Zareh Rafie M; ''Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study.''; Int J Mol Sci, 2021 PubMed Europe PMC Scholia
  12. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H; ''An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.''; J Proteomics, 2014 PubMed Europe PMC Scholia
  13. Riley KN, Catalano LM, Bernat JA, Adams SD, Martin DM, Lalani SR, Patel A, Burnside RD, Innis JW, Rudd MK; ''Recurrent deletions and duplications of chromosome 2q11.2 and 2q13 are associated with variable outcomes.''; Am J Med Genet A, 2015 PubMed Europe PMC Scholia
  14. Hirata T, Fujita M, Nakamura S, Gotoh K, Motooka D, Murakami Y, Maeda Y, Kinoshita T; ''''; , PubMed Europe PMC Scholia
  15. Hagting A, Den Elzen N, Vodermaier HC, Waizenegger IC, Peters JM, Pines J; ''Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.''; J Cell Biol, 2002 PubMed Europe PMC Scholia
  16. Baumgart E, Vanhooren JC, Fransen M, Marynen P, Puype M, Vandekerckhove J, Leunissen JA, Fahimi HD, Mannaerts GP, van Veldhoven PP; ''Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome.''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC Scholia
  17. Hannan RD, Hempel WM, Cavanaugh A, Arino T, Dimitrov SI, Moss T, Rothblum L; ''Affinity purification of mammalian RNA polymerase I. Identification of an associated kinase.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  18. O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC; ''Bim: a novel member of the Bcl-2 family that promotes apoptosis.''; EMBO J, 1998 PubMed Europe PMC Scholia
  19. Spolski R, Li P, Leonard WJ; ''Biology and regulation of IL-2: from molecular mechanisms to human therapy.''; Nat Rev Immunol, 2018 PubMed Europe PMC Scholia
  20. Spolski R, Li P, Leonard WJ; ''''; , PubMed Europe PMC Scholia
  21. Lemke G, Rothlin CV; ''Immunobiology of the TAM receptors.''; Nat Rev Immunol, 2008 PubMed Europe PMC Scholia
  22. Cecil DL, Rose DM, Terkeltaub R, Liu-Bryan R; ''Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes.''; Arthritis Rheum, 2005 PubMed Europe PMC Scholia
  23. Baillat D, Hakimi MA, Näär AM, Shilatifard A, Cooch N, Shiekhattar R; ''Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.''; Cell, 2005 PubMed Europe PMC Scholia
  24. Geley S, Kramer E, Gieffers C, Gannon J, Peters JM, Hunt T; ''Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.''; J Cell Biol, 2001 PubMed Europe PMC Scholia
  25. Fernandes I, Béliveau R, Friedlander G, Silve C; ''NaPO(4) cotransport type III (PiT1) expression in human embryonic kidney cells and regulation by PTH.''; Am J Physiol, 1999 PubMed Europe PMC Scholia
  26. Caberoy NB, Zhou Y, Li W; ''Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis.''; EMBO J, 2010 PubMed Europe PMC Scholia
  27. Chang LF, Zhang Z, Yang J, McLaughlin SH, Barford D; ''Molecular architecture and mechanism of the anaphase-promoting complex.''; Nature, 2014 PubMed Europe PMC Scholia
  28. Hofmann S, Rothbauer U, Mühlenbein N, Baiker K, Hell K, Bauer MF; ''Functional and mutational characterization of human MIA40 acting during import into the mitochondrial intermembrane space.''; J Mol Biol, 2005 PubMed Europe PMC Scholia
  29. Watari K, Shibata T, Kawahara A, Sata K, Nabeshima H, Shinoda A, Abe H, Azuma K, Murakami Y, Izumi H, Takahashi T, Kage M, Kuwano M, Ono M; ''Tumor-derived interleukin-1 promotes lymphangiogenesis and lymph node metastasis through M2-type macrophages.''; PLoS One, 2014 PubMed Europe PMC Scholia
  30. U M, Miyashita T, Shikama Y, Tadokoro K, Yamada M; ''Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family.''; FEBS Lett, 2001 PubMed Europe PMC Scholia
  31. Hwang ES, Choi A, Ho IC; ''Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1.''; J Immunol, 2002 PubMed Europe PMC Scholia
  32. Ni Z, Xu C, Guo X, Hunter GO, Kuznetsova OV, Tempel W, Marcon E, Zhong G, Guo H, Kuo WW, Li J, Young P, Olsen JB, Wan C, Loppnau P, El Bakkouri M, Senisterra GA, He H, Huang H, Sidhu SS, Emili A, Murphy S, Mosley AL, Arrowsmith CH, Min J, Greenblatt JF; ''RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.''; Nat Struct Mol Biol, 2014 PubMed Europe PMC Scholia
  33. Comai L; ''Mechanism of RNA polymerase I transcription.''; Adv Protein Chem, 2004 PubMed Europe PMC Scholia
  34. Chen JZ, Ji CN, Gu SH, Li JX, Zhao EP, Huang Y, Huang L, Ying K, Xie Y, Mao YM; ''Over-expression of Bim alpha3, a novel isoform of human Bim, result in cell apoptosis.''; Int J Biochem Cell Biol, 2004 PubMed Europe PMC Scholia
  35. Yumoto T, Nakadate K, Nakamura Y, Sugitani Y, Sugitani-Yoshida R, Ueda S, Sakakibara S; ''Radmis, a novel mitotic spindle protein that functions in cell division of neural progenitors.''; PLoS One, 2013 PubMed Europe PMC Scholia
  36. Seither P, Grummt I; ''Molecular cloning of RPA2, the gene encoding the second largest subunit of mouse RNA polymerase I.''; Genomics, 1996 PubMed Europe PMC Scholia
  37. Bøttger P, Pedersen L; ''Mapping of the minimal inorganic phosphate transporting unit of human PiT2 suggests a structure universal to PiT-related proteins from all kingdoms of life.''; BMC Biochem, 2011 PubMed Europe PMC Scholia
  38. Marani M, Tenev T, Hancock D, Downward J, Lemoine NR; ''Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.''; Mol Cell Biol, 2002 PubMed Europe PMC Scholia
  39. Mouhamad S, Besnault L, Auffredou MT, Leprince C, Bourgeade MF, Leca G, Vazquez A; ''B cell receptor-mediated apoptosis of human lymphocytes is associated with a new regulatory pathway of Bim isoform expression.''; J Immunol, 2004 PubMed Europe PMC Scholia
  40. Lennard AC; ''lnterleukin-1 Receptor Antagonist.''; Crit Rev Immunol, 2017 PubMed Europe PMC Scholia
  41. Hu D, Smith ER, Garruss AS, Mohaghegh N, Varberg JM, Lin C, Jackson J, Gao X, Saraf A, Florens L, Washburn MP, Eissenberg JC, Shilatifard A; ''The little elongation complex functions at initiation and elongation phases of snRNA gene transcription.''; Mol Cell, 2013 PubMed Europe PMC Scholia
  42. Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J; ''FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  43. Sims JE, Smith DE; ''The IL-1 family: regulators of immunity.''; Nat Rev Immunol, 2010 PubMed Europe PMC Scholia
  44. Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO; ''Structural basis of tubulin tyrosination by tubulin tyrosine ligase.''; J Cell Biol, 2013 PubMed Europe PMC Scholia
  45. Derrien V, Couillault C, Franco M, Martineau S, Montcourrier P, Houlgatte R, Chavrier P; ''A conserved C-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions.''; J Cell Sci, 2002 PubMed Europe PMC Scholia
  46. Tominaga K, Yoshimoto T, Torigoe K, Kurimoto M, Matsui K, Hada T, Okamura H, Nakanishi K; ''IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.''; Int Immunol, 2000 PubMed Europe PMC Scholia
  47. Jia H, Liu J, Han B; ''Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases.''; Biomed Res Int, 2018 PubMed Europe PMC Scholia
  48. Wen L, Liang DS, Wu LQ, Cai F, Pan Q, Long ZG, Dai HP, Xia K, Xia JH; ''Efficient protein expression from the endogenous RNA polymerase I promoter using a human ribosomal DNA targeting vector.''; Biochem Biophys Res Commun, 2008 PubMed Europe PMC Scholia
  49. Chen J, Carey K, Godowski PJ; ''Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation.''; Oncogene, 1997 PubMed Europe PMC Scholia
  50. Hannan RD, Cavanaugh A, Hempel WM, Moss T, Rothblum L; ''Identification of a mammalian RNA polymerase I holoenzyme containing components of the DNA repair/replication system.''; Nucleic Acids Res, 1999 PubMed Europe PMC Scholia
  51. Vanhove GF, Van Veldhoven PP, Fransen M, Denis S, Eyssen HJ, Wanders RJ, Mannaerts GP; ''The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acidsare oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney.''; J Biol Chem, 1993 PubMed Europe PMC Scholia
  52. Hafizi S, Dahlbäck B; ''Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases.''; Cytokine Growth Factor Rev, 2006 PubMed Europe PMC Scholia
  53. Barisic M, Silva e Sousa R, Tripathy SK, Magiera MM, Zaytsev AV, Pereira AL, Janke C, Grishchuk EL, Maiato H; ''Mitosis. Microtubule detyrosination guides chromosomes during mitosis.''; Science, 2015 PubMed Europe PMC Scholia
  54. Chakraborty P, Dash SP, Sarangi PP; ''The role of adhesion protein Fibulin7 in development and diseases.''; Mol Med, 2020 PubMed Europe PMC Scholia
  55. Beck L, Leroy C, Salaün C, Margall-Ducos G, Desdouets C, Friedlander G; ''Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity.''; J Biol Chem, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
122737view12:50, 7 May 2022Shad4Added neuropathologies
122625view09:51, 22 April 2022Shad4Modified description
122601view18:22, 20 April 2022Shad4Converted labels into processes without id and database
122598view12:37, 20 April 2022FehrhartOntology Term : 'disease pathway' added !
122551view11:28, 15 April 2022Shad4New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACOXLProteinENSG00000153093 (Ensembl)
ANAPC1GeneProductENSG00000153107 (Ensembl)
APC/C complexComplexCPX-1860
ARF6ProteinENSG00000165527 (Ensembl)
ARL14ProteinENSG00000179674 (Ensembl)
Anti-inflammatory cytokines
ApoptosisPathwayWP254 (WikiPathways)
B cell proliferationQ14863410 (Wikidata)
BCL2L11GeneProductENSG00000153094 (Ensembl)
CHCHD5GeneProductENSG00000125611 (Ensembl)
CKAP2LGeneProductENSG00000169607 (Ensembl)
CSF1ProteinENSG00000184371 (Ensembl)
CSF2ProteinENSG00000164400 (Ensembl)
CXCL13ProteinENSG00000156234 (Ensembl)
Canonical NF-kB pathwayPathwayWP4562 (WikiPathways)
Carboxyterminal

post-translational

modifications of tubulin		PathwayWP4075 (WikiPathways)
Epithelial inflammatory response
FADMetaboliteCHEBI:57692 (ChEBI)
FBLN7GeneProductENSG00000144152 (Ensembl)
FILIPPI SYNDROME; FLPIS272440
GAS6ProteinENSG00000183087 (Ensembl)
GATA3ProteinENSG00000107485 (Ensembl)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2ProteinENSG00000177885 (Ensembl)
GTPMetaboliteCHEBI:37565 (ChEBI)
HMGN2P23GeneProductENSG00000236124 (Ensembl)
IL-1 signaling pathwayPathwayWP195 (WikiPathways)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL1F10GeneProductENSG00000136697 (Ensembl)
IL1R1ProteinENSG00000115594 (Ensembl)
IL1RAPProteinENSG00000196083 (Ensembl)
IL1RL2ProteinENSG00000115598 (Ensembl)
IL1RNGeneProductENSG00000136689 (Ensembl)
IL23AProteinENSG00000110944 (Ensembl)
IL2ProteinENSG00000109471 (Ensembl)
IL36AGeneProductENSG00000136694 (Ensembl)
IL36BGeneProductENSG00000136696 (Ensembl)
IL36GGeneProductENSG00000136688 (Ensembl)
IL36RNGeneProductENSG00000136695 (Ensembl)
IL37GeneProductENSG00000125571 (Ensembl)
IL6ProteinENSG00000136244 (Ensembl)
LGALS3ProteinENSG00000131981 (Ensembl)
MAPK cascadePathwayWP422 (WikiPathways)
MAPK1ProteinENSG00000100030 (Ensembl)
MERTKGeneProductENSG00000153208 (Ensembl)
MIR4435-1GeneProductENSG00000266139 (Ensembl)
MIR4435-1HGGeneProductENSG00000172965 (Ensembl)
MIR4435-2GeneProductENSG00000266139 (Ensembl)
MIR4771-1GeneProductENSG00000266063 (Ensembl)
MIR4771-2GeneProductENSG00000266063 (Ensembl)
Mitochondrial protein importPathwayWP2717 (WikiPathways)
NEUROPATHOLOGY
NT5DC4GeneProductENSG00000144130 (Ensembl)
Na+MetaboliteCHEBI:29101 (ChEBI)
PLCG2GeneProductENSG00000197943 (Ensembl)
POLR1AGeneProductENSG00000068654 (Ensembl)
POLR1BGeneProductENSG00000125630 (Ensembl)
POLR1CGeneProductENSG00000171453 (Ensembl)
POLR1DGeneProductENSG00000186184 (Ensembl)
POLR1EGeneProductENSG00000137054 (Ensembl)
POLR1FGeneProductENSG00000105849 (Ensembl)
POLR1GGeneProductENSG00000117877 (Ensembl)
POLR1HGeneProductENSG00000066379 (Ensembl)
POLR2EGeneProductENSG00000099817 (Ensembl)
POLR2FGeneProductENSG00000100142 (Ensembl)
POLR2HGeneProductENSG00000163882 (Ensembl)
POLR2KGeneProductENSG00000147669 (Ensembl)
POLR2LGeneProductENSG00000177700 (Ensembl)
PSD4GeneProductENSG00000125637 (Ensembl)
PTK2ProteinENSG00000169398 (Ensembl)
Peroxisomal lipid metabolismPathwayWP1878 (WikiPathways)
PiMetaboliteCHEBI:43474 (ChEBI)
RAC1ProteinENSG00000136238 (Ensembl)
RGPD8GeneProductENSG00000169629 (Ensembl)
RN7SL297PGeneProductENSG00000240183 (Ensembl)
RNA Polymerase I TranscriptionPathwayWP4074 (WikiPathways)
RNA pol I holoenzymeComplex
RNU6-1180PGeneProductENSG00000201805 (Ensembl)
RPL5P9GeneProductENSG00000236330 (Ensembl)
RPS14P4GeneProductENSG00000226928 (Ensembl)
Regulation of mitotic cell cyclePathwayWP4109 (WikiPathways)
SLC20A1GeneProductENSG00000144136 (Ensembl)
SOCS1ProteinENSG00000185338 (Ensembl)
SOCS3ProteinENSG00000184557 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
TMEM87BGeneProductENSG00000153214 (Ensembl)
TTLGeneProductENSG00000114999 (Ensembl)
TULP1ProteinENSG00000112041 (Ensembl)
Teeth development
ZC3H6GeneProductENSG00000188177 (Ensembl)
ZC3H8GeneProductENSG00000144161 (Ensembl)
actin cytoskeleton reorganization Q14908027 (Wikidata)
dendritic cellQ506253 (Wikidata)
extracellular matrixQ193825 (Wikidata)
immature T cell proliferation in thymusQ15321801 (Wikidata)
immunomodulationQ27788458 (Wikidata)
innate immune responseQ428253 (Wikidata)
macrophageQ184204 (Wikidata)
microtubuleQ189933 (Wikidata)
mitotic spindle assemblyQ14912279 (Wikidata)
odontoblastQ853338 (Wikidata)
proteinsMetaboliteCHEBI:36080 (ChEBI)
snRNA transcription by RNA polymerase IIQ21114367 (Wikidata)
transcription elongation factor complexComplexQ15314914 (Wikidata)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5222"
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