2q37 copy number variation syndrome (Homo sapiens)

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NucleusSensory neuronMYO5A151, 18733, 1074, 92, 110, 133, 189...77109147, 197148108192, 22123, 14026, 74137, 173199131, 21189, 135, 182, 201, 220130170, 2088514249, 52, 160, 1947, 24, 79, 16386, 12850, 99, 1042, 48, 90, 93, 106...4, 92, 110, 161, 18994, 111, 117, 193, 21573, 2229, 204, 2281693, 14, 22, 29, 39...88, 2051361643043, 62, 17437, 42, 112, 1161534111311, 72836, 75, 9664, 165, 1814721631, 91, 195, 22387, 13245, 124, 143, 157, 178180, 190, 213Axons/Dendrites44, 4617134, 158, 22412, 34, 139, 144, 145, 149...179, 2006395, 11967, 76, 207proteins98, 10024, 16338, 80, 101, 218159, 22621925, 35, 19920, 21, 81, 11868, 12716, 19675, 85, 2148, 1525, 58, 167, 184, 203156, 175188183, 20217120, 217113, 55, 12510, 15, 975732, 6127, 36, 103, 18660, 102, 122, 172, 1771627019819, 84, 115ATG8 familyAcetylation ofhistone H4DCVMitochondrionribosomeSynaptic siteExact function unknownchr2:239,716,679230Sensation of coldExact function unknownExact function unknownCold temperatures and cooling agentsDepolarizationChanging environmental conditions Exact function unknownGlycogen synthesis and degradationMAP4rRNA modificationin the mitochondrionoxidative stressHBO1-5.1 histoneacetyltransferase complexSCF-like ECS E3ligase complexGDPsterol metabolic processUDP-glucuronosyl/UDP-glucosyltransferaseProtein phosphatase 1ProteinOlfactory receptor activityFilament-forming complexprotein-serine-threonine kinasesmitotic spindle assemblyUBA3-NAE1 E1 complexextracellular matrixactin cytoskeleton reorganizationMOZ1 histoneacetyltransferase complexGDPtubulinCilium Assemblycysteine proteaseMyogenesisCOP9 signalosome variant 1bone remodelingbleeding NeddylationCircadian Clockaminopeptidase activitySignaling by FGFR2microtubuleProtein-tyrosine-phosphataseactinMitochondrial respiratory chain complex IerythroblastElectron transport chain:OXPHOS system in mitochondriaProtein ubiquitinationCell junction organizationhistone deacetylase activityPIP3intercellular bridgeMAPK cascadepositive regulation of smooth muscle cell proliferationProlactin receptorsignalingprotein ubiquitinationAmino acids regulate mTORC1Endothelin pathwaysCOP9 signalosomevesicle transportalong microtubuleTransferrin receptormelanosomecollagen VINeural crest differentiationmelanosome transportCENP-A nucleosome complexEstrogen metabolismclathrin-dependent endocytosisGABARAPCFLARGMEB1dTMPCancer immunotherapy by PD-1 blockadeGABARAPL1CALM1GABARAPL2dTDPAGAP1-IT1MAP1LC3CSNED1MAP1LC3AABCA1MAP1LC3BMYEOV2peroxynitriteOR5S1PnitrateMEF2C(R)-2-hydroxyglutaratePDCD1NFKBIA2-oxoglutarateNEDD8MLPHOR9S24PUGT1A10HSPE1P9SPP2USP40MIR4786RN7SL204PTNFSH3BP4ARF1UGT1A13PCXCR4ANKMY1DUSP28ACKR3SH3BP4UBE2FPhosphatidic acidRNU1-31PFAM132BRAB17SEPTIN2PDX1EEF1A1RAMP1ATG4BDNAJB3RAB27ARAMP1ASB18MEF2APRR21HAMPRNU6-1051PHDAC4DTYMKTRPM8IL13RA1ARL4CRBM44UGT1A5NDUFA10RRAGCOTOSSTK25EGFRGPC1D2HGDHUGT1A2PAGAP1OR6B3SEPTIN12GBX2RNU6-1333PPRLMIR4269CAPN10-AS1C2orf54KLHL30HDLBPILKAPUGT1A6TRAF3IP1TMSB10P1COL6A3RNU7-127PCAPN10MIR4440PER2UBE2F-SCLYH2Oacceptor beta-D-glucuronosideUGT1A11PRAC1UGT1A8HES1heparan sulfate groupRRAGDRPL17P11CALCAGPR35OR6B2phosphatidylserineAQP12ABOKkynurenic acidCXCL12IQCA1JUNRRAGBGPC1MLPHLRRFIP1Ca2+LINC01107CYTH1HES6PASKRNU6-234PMIR2467RNA5SP122ANO7TRAF3CXXC11NEU4TRPM8glucuronate acceptorL-selenocysteineMYOD1ING5FARP2CALCRLRNPEPL1MIR149L-alanineMTERFD2MSL3P1CENPAITGB3DGKD1,2-diacyl-sn-glycerolsAGXTTHAP4ARF5CXCL11SEPTIN6GAL3ST2cholesterolCa2+MIR4441MYOGUGT1A1SEPTIN4L-alanineMIR3133TP53HJURPSCLYCOPS8DISC1UGT1A7ESPNLITPK1MROH2AUGT1A3PDGFATWIST2UGT1A12PRNU6-1140PBOK-AS1RPL3P5PRLHCICP10KIF1AAQP12AUGT1A9RPS6IRF8Na+PPP1R7pyruvateUGT1A4IL1BAQP12BILKSEPT2GYS1ASCL1ANO7ASB1RRAGACa2+Na+ARL4CCYTH2CYTH4CYTH357, 166575740, 82ARF5ARF117966, 154, 212154, 212NFKBIAIRF8TP53JUNITPK138, 80, 101, 21838, 80, 101, 21813444, 4644, 4644, 4644, 46Exact function unknownAQP12BH2O19, 115Exact function unknownRPS6EEF1A1GYS1PDX15912128galactosylceramidephosphatidylcholinephosphatidylserinegalactosylceramidephosphatidylcholine43, 62, 17443, 62, 174RAC1Acetylation ofhistone H3188553, 54, 19124, 78, 105, 163Metapathway biotransformationPhase I and IIExact function unknowncholesterolTransferrin receptorPIP2Factors and pathways affectinginsulin-like growth factor(IGF1)-Akt signalingInterleukin-4 andInterleukin-13 signalingOlfactory receptor activitysensory perception of sound Ca2+Integrin-mediated cell adhesionDegradation of the extracellular matrixG proteinsignaling pathwaysDCVSemaphorin interactionsIntegrin signalingApoptosisMacroautophagyCitric acid cycle andrespiratory electron transport MetapathwaybiotransformationPhase I and IISialic acid metabolismLegendTranslocationGene ProductMetaboliteRNA geneMIM-stimulation of an enzyme or a gene leading to its activation or expressionData node for a micro RNA or another RNA geneData node for a pathwayMIM-inhibition of a compound's function or a processMIM-catalysis of a compound by an enzymePathwayMIM-transcription-translation of a geneData node for a metaboliteDashed line indicates unclear mechanismof interaction/unclear intermediatesData node for a gene or its productMIM-conversion of a compound to anotherMIM-binding of a compound to anotherData node for a pseudo genePseudogeneproteinsPhosphorylated proteinComplexchr2:234,275,216187chr2:243,199,373SCF-like ECS E3 ligase complex151, 23089, 135, 182, 201, 22053, 54, 19153, 54, 19153, 54, 19153, 54, 19153, 54, 19153, 54, 19153, 54, 191GTP53, 54, 191GTPGDPGTP5, 58, 167, 184, 203NEUROPATHOLOGYData node for associated neuropathologyD-2-HYDROXYGLUTARIC ACIDURIA 1; D2HGA1SPASTIC PARAPLEGIA 30, AUTOSOMAL DOMINANT; SPG30Alzheimer diseaseMITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 22; MC1DN22


Description

The 2q37 copy number variation syndrome can result in the loss of up to 78 protein-coding genes. Patients with 2q37 CNV syndrome had intellectual disability, facial dysmorphism and skeletal and digit malformations (DOI: 10.1186/1755-8794-7-19,DOI: 10.1016/j.gene.2013.06.056). Research linked changes in HDAC4 gene with obesity of 2q37 patients (DOI: 10.1016/j.gene.2013.06.056). The chromosomal locations are from Kirov et al. 2014 (literature cited there) (chr2:239,716,679-243,199,373) and the larger one from Sakai et al. 2014 (chr2:234,275,216-243,199,373).

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  199. Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ; ''HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor.''; Mol Cell Biol, 1999 PubMed Europe PMC Scholia
  200. Cuthbert EJ, Davis KK, Casanova JE; ''Substrate specificities and activities of AZAP family Arf GAPs in vivo.''; Am J Physiol Cell Physiol, 2008 PubMed Europe PMC Scholia
  201. Balabanian K, Lagane B, Infantino S, Chow KY, Harriague J, Moepps B, Arenzana-Seisdedos F, Thelen M, Bachelerie F; ''The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  202. Zhao CL, Hui Y, Wang LJ, Yang D, Yakirevich E, Mangray S, Huang CK, Lu S; ''Alanine-glyoxylate aminotransferase 1 (AGXT1) is a novel marker for hepatocellular carcinomas.''; Hum Pathol, 2018 PubMed Europe PMC Scholia
  203. Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B; ''The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels.''; Nature, 2004 PubMed Europe PMC Scholia
  204. Shiozaki K, Yamaguchi K, Takahashi K, Moriya S, Miyagi T; ''Regulation of sialyl Lewis antigen expression in colon cancer cells by sialidase NEU4.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  205. Lee LS, Cheng Y; ''Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia.''; J Biol Chem, 1977 PubMed Europe PMC Scholia
  206. Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F; ''Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
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  208. Burckhardt CJ, Minna JD, Danuser G; ''SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt.''; Dev Cell, 2021 PubMed Europe PMC Scholia
  209. Haliloglu G, Temucin CM, Oguz KK, Celiker A, Coskun T, Sass JO, Fischer J, Topcu M; ''Peripheral neuropathy in a patient with D-2-hydroxyglutaric aciduria.''; J Inherit Metab Dis, 2009 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
127064view15:58, 26 July 2023FehrhartModified description
127063view15:56, 26 July 2023FehrhartAdded information on chromosomal location found in the Kirov et al. 2014 paper
122740view13:12, 7 May 2022Shad4Added neuropathologies
122633view10:56, 22 April 2022FehrhartOntology Term : 'disease pathway' added !
122627view09:58, 22 April 2022Shad4Modified description
122603view18:31, 20 April 2022Shad4Connected unconnected lines
122575view19:05, 16 April 2022Shad4New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(R)-2-hydroxyglutarateMetaboliteCHEBI:15801 (ChEBI)
1,2-diacyl-sn-glycerolsMetaboliteCHEBI:17815 (ChEBI)
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
ABCA1ProteinENSG00000165029 (Ensembl)
ACKR3GeneProductENSG00000144476 (Ensembl)
AGAP1-IT1GeneProductENSG00000235529 (Ensembl)
AGAP1GeneProductENSG00000157985 (Ensembl)
AGXTGeneProductENSG00000172482 (Ensembl)
ANKMY1GeneProductENSG00000144504 (Ensembl)
ANO7GeneProductENSG00000146205 (Ensembl)
AQP12AProteinENSG00000184945 (Ensembl)
AQP12BProteinENSG00000185176 (Ensembl)
ARF1ProteinENSG00000143761 (Ensembl)
ARF5ProteinENSG00000004059 (Ensembl)
ARL4CProteinENSG00000188042 (Ensembl)
ASB18GeneProductENSG00000182177 (Ensembl)
ASB1GeneProductENSG00000065802 (Ensembl)
ASCL1ProteinENSG00000139352 (Ensembl)
ATG4BGeneProductENSG00000168397 (Ensembl)
Alzheimer disease
Amino acids regulate mTORC1PathwayWP5015 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
BOK-AS1GeneProductENSG00000234235 (Ensembl)
BOKGeneProductENSG00000176720 (Ensembl)
C2orf54GeneProductENSG00000172478 (Ensembl)
CALCAProteinENSG00000110680 (Ensembl)
CALCRLGeneProductENSG00000064989 (Ensembl)
CALM1ProteinENSG00000198668 (Ensembl)
CAPN10-AS1GeneProductENSG00000260942 (Ensembl)
CAPN10GeneProductENSG00000142330 (Ensembl)
CENP-A nucleosome complexComplexCPX-5647
CENPAProteinENSG00000115163 (Ensembl)
CFLARProteinENSG00000003402 (Ensembl)
CICP10GeneProductENSG00000224160 (Ensembl)
COL6A3GeneProductENSG00000163359 (Ensembl)
COP9 signalosome variant 1ComplexCPX-1870
COP9 signalosomeComplexCPX-1870
COPS8GeneProductENSG00000198612 (Ensembl)
CXCL11ProteinENSG00000169248 (Ensembl)
CXCL12ProteinENSG00000107562 (Ensembl)
CXCR4ProteinENSG00000121966 (Ensembl)
CXXC11GeneProductENSG00000188011 (Ensembl)
CYTH1ProteinENSG00000108669 (Ensembl)
CYTH2ProteinENSG00000105443 (Ensembl)
CYTH3ProteinENSG00000008256 (Ensembl)
CYTH4ProteinENSG00000100055 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cancer immunotherapy by PD-1 blockadePathwayWP4585 (WikiPathways)
Cell junction organizationPathwayWP1793 (WikiPathways)
Cilium AssemblyPathwayWP4124 (WikiPathways)
Circadian ClockPathwayWP1797 (WikiPathways)
Citric acid cycle and respiratory electron transport PathwayWP2766 (WikiPathways)
D-2-HYDROXYGLUTARIC ACIDURIA 1; D2HGA1600721
D2HGDHGeneProductENSG00000180902 (Ensembl)
DGKDGeneProductENSG00000077044 (Ensembl)
DISC1ProteinENSG00000162946 (Ensembl)
DNAJB3GeneProductENSG00000227802 (Ensembl)
DTYMKGeneProductENSG00000168393 (Ensembl)
DUSP28GeneProductENSG00000188542 (Ensembl)
Degradation of the extracellular matrixPathwayWP2774 (WikiPathways)
EEF1A1ProteinENSG00000156508 (Ensembl)
EGFRProteinENSG00000146648 (Ensembl)
ESPNLGeneProductENSG00000144488 (Ensembl)
Electron transport chain: OXPHOS system in mitochondriaPathwayWP111 (WikiPathways)
Endothelin pathwaysPathwayWP2197 (WikiPathways)
Estrogen metabolismPathwayWP697 (WikiPathways)
FAM132BGeneProductENSG00000178752 (Ensembl)
FARP2GeneProductENSG00000006607 (Ensembl)
Factors and pathways affecting

insulin-like growth factor

(IGF1)-Akt signaling		PathwayWP3850 (WikiPathways)
Filament-forming complexComplex
G protein signaling pathwaysPathwayWP35 (WikiPathways)
GABARAPProteinENSG00000170296 (Ensembl)
GABARAPL1ProteinENSG00000139112 (Ensembl)
GABARAPL2ProteinENSG00000034713 (Ensembl)
GAL3ST2GeneProductENSG00000154252 (Ensembl)
GBX2GeneProductENSG00000168505 (Ensembl)
GDPMetaboliteCHEBI:17552 (ChEBI)
GMEB1ProteinENSG00000162419 (Ensembl)
GPC1GeneProductENSG00000063660 (Ensembl)
GPR35GeneProductENSG00000178623 (Ensembl)
GTPMetaboliteCHEBI:37565 (ChEBI)
GYS1ProteinENSG00000104812 (Ensembl)
Glycogen synthesis and degradationPathwayWP500 (WikiPathways)
H2OMetaboliteCHEBI:15377 (ChEBI)
HAMPProteinENSG00000105697 (Ensembl)
HBO1-5.1 histone acetyltransferase complexComplexCPX-721
HDAC4GeneProductENSG00000068024 (Ensembl)
HDLBPGeneProductENSG00000115677 (Ensembl)
HES1ProteinENSG00000114315 (Ensembl)
HES6GeneProductENSG00000144485 (Ensembl)
HJURPGeneProductENSG00000123485 (Ensembl)
HSPE1P9GeneProductENSG00000232690 (Ensembl)
IL13RA1ProteinENSG00000131724 (Ensembl)
IL1BProteinENSG00000125538 (Ensembl)
ILKAPGeneProductENSG00000132323 (Ensembl)
ILKProteinENSG00000166333 (Ensembl)
ING5GeneProductENSG00000168395 (Ensembl)
IQCA1GeneProductENSG00000132321 (Ensembl)
IRF8ProteinENSG00000140968 (Ensembl)
ITGB3ProteinENSG00000259207 (Ensembl)
ITPK1ProteinENSG00000100605 (Ensembl)
Integrin signalingPathwayWP4431 (WikiPathways)
Integrin-mediated cell adhesionPathwayWP185 (WikiPathways)
Interleukin-4 and Interleukin-13 signalingPathwayWP4066 (WikiPathways)
JUNProteinENSG00000177606 (Ensembl)
KIF1AGeneProductENSG00000130294 (Ensembl)
KLHL30GeneProductENSG00000168427 (Ensembl)
L-alanineMetaboliteCHEBI:57972 (ChEBI)
L-selenocysteineMetaboliteCHEBI:57843 (ChEBI)
LINC01107GeneProductENSG00000225493 (Ensembl)
LRRFIP1GeneProductENSG00000124831 (Ensembl)
MAP1LC3AProteinENSG00000101460 (Ensembl)
MAP1LC3BProteinENSG00000140941 (Ensembl)
MAP1LC3CProteinENSG00000197769 (Ensembl)
MAP4ProteinENSG00000047849 (Ensembl)
MAPK cascadePathwayWP422 (WikiPathways)
MEF2AProteinENSG00000068305 (Ensembl)
MEF2CProteinENSG00000081189 (Ensembl)
MIR149GeneProductENSG00000207611 (Ensembl)
MIR2467GeneProductENSG00000264292 (Ensembl)
MIR3133GeneProductENSG00000263752 (Ensembl)
MIR4269GeneProductENSG00000265215 (Ensembl)
MIR4440GeneProductENSG00000266109 (Ensembl)
MIR4441GeneProductENSG00000264810 (Ensembl)
MIR4786GeneProductENSG00000264279 (Ensembl)
MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 22; MC1DN22618243
MLPHProteinENSG00000115648 (Ensembl)
MOZ1 histone acetyltransferase complexComplexCPX-727
MROH2AGeneProductENSG00000185038 (Ensembl)
MSL3P1GeneProductENSG00000224287 (Ensembl)
MTERFD2GeneProductENSG00000122085 (Ensembl)
MYEOV2GeneProductENSG00000172428 (Ensembl)
MYO5AProteinENSG00000197535 (Ensembl)
MYOD1ProteinENSG00000129152 (Ensembl)
MYOGProteinENSG00000122180 (Ensembl)
MacroautophagyPathwayWP3348 (WikiPathways)
Metapathway

biotransformation

Phase I and II		PathwayWP702 (WikiPathways)
Metapathway biotransformation Phase I and IIPathwayWP702 (WikiPathways)
Mitochondrial respiratory chain complex IComplexCPX-577
MyogenesisPathwayWP1865 (WikiPathways)
NDUFA10GeneProductENSG00000130414 (Ensembl)
NEDD8ProteinENSG00000129559 (Ensembl)
NEU4GeneProductENSG00000204099 (Ensembl)
NEUROPATHOLOGY
NFKBIAProteinENSG00000100906 (Ensembl)
Na+MetaboliteCHEBI:29101 (ChEBI)
NeddylationPathwayWP4121 (WikiPathways)
Neural crest differentiationPathwayWP2064 (WikiPathways)
OR5S1PGeneProductENSG00000213048 (Ensembl)
OR6B2GeneProductENSG00000182083 (Ensembl)
OR6B3GeneProductENSG00000178586 (Ensembl)
OR9S24PGeneProductENSG00000231278 (Ensembl)
OTOSGeneProductENSG00000178602 (Ensembl)
Olfactory receptor activityPathwayWP3608 (WikiPathways)
PASKGeneProductENSG00000115687 (Ensembl)
PDCD1GeneProductENSG00000188389 (Ensembl)
PDGFAProteinENSG00000197461 (Ensembl)
PDX1ProteinENSG00000139515 (Ensembl)
PER2GeneProductENSG00000132326 (Ensembl)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PPP1R7GeneProductENSG00000115685 (Ensembl)
PRLProteinENSG00000172179 (Ensembl)
PRLHGeneProductENSG00000071677 (Ensembl)
PRR21GeneProductENSG00000260610 (Ensembl)
Phosphatidic acidMetaboliteCHEBI:58608 (ChEBI)
Prolactin receptor signalingPathwayWP2678 (WikiPathways)
ProteinProtein
Protein phosphatase 1Complex
Protein ubiquitinationPathwayWP4125 (WikiPathways)
Protein-tyrosine-phosphatase10684 (Rhea)
RAB17GeneProductENSG00000124839 (Ensembl)
RAB27AProteinENSG00000069974 (Ensembl)
RAC1ProteinENSG00000136238 (Ensembl)
RAMP1GeneProductENSG00000132329 (Ensembl)
RBM44GeneProductENSG00000177483 (Ensembl)
RN7SL204PGeneProductENSG00000264676 (Ensembl)
RNA5SP122GeneProductENSG00000207186 (Ensembl)
RNPEPL1GeneProductENSG00000142327 (Ensembl)
RNU1-31PGeneProductENSG00000200745 (Ensembl)
RNU6-1051PGeneProductENSG00000202341 (Ensembl)
RNU6-1140PGeneProductENSG00000222449 (Ensembl)
RNU6-1333PGeneProductENSG00000251971 (Ensembl)
RNU6-234PGeneProductENSG00000202099 (Ensembl)
RNU7-127PGeneProductENSG00000238812 (Ensembl)
RPL17P11GeneProductENSG00000233445 (Ensembl)
RPL3P5GeneProductENSG00000231546 (Ensembl)
RPS6ProteinENSG00000137154 (Ensembl)
RRAGAProteinENSG00000155876 (Ensembl)
RRAGBProteinENSG00000083750 (Ensembl)
RRAGCProteinENSG00000116954 (Ensembl)
RRAGDProteinENSG00000025039 (Ensembl)
SCF-like ECS E3 ligase complexComplex
SCF-like ECS E3 ligase complexComplex
SCLYGeneProductENSG00000132330 (Ensembl)
SEPT2GeneProductENSG00000168385 (Ensembl)
SEPTIN12ProteinENSG00000140623 (Ensembl)
SEPTIN2ProteinENSG00000168385 (Ensembl)
SEPTIN4ProteinENSG00000108387 (Ensembl)
SEPTIN6ProteinENSG00000125354 (Ensembl)
SH3BP4GeneProductENSG00000130147 (Ensembl)
SNED1GeneProductENSG00000162804 (Ensembl)
SPASTIC PARAPLEGIA 30, AUTOSOMAL DOMINANT; SPG30610357
SPP2GeneProductENSG00000072080 (Ensembl)
STK25GeneProductENSG00000115694 (Ensembl)
Semaphorin interactionsPathwayWP1907 (WikiPathways)
Sialic acid metabolismPathwayWP3363 (WikiPathways)
Signaling by FGFR2PathwayWP3338 (WikiPathways)
THAP4GeneProductENSG00000176946 (Ensembl)
TMSB10P1GeneProductENSG00000228499 (Ensembl)
TNFProteinENSG00000232810 (Ensembl)
TP53ProteinENSG00000141510 (Ensembl)
TRAF3ProteinENSG00000131323 (Ensembl)
TRAF3IP1GeneProductENSG00000204104 (Ensembl)
TRPM8GeneProductENSG00000144481 (Ensembl)
TWIST2GeneProductENSG00000233608 (Ensembl)
Transferrin receptorQ21112583 (Wikidata)
UBA3-NAE1 E1 complexComplex
UBE2F-SCLYGeneProductENSG00000258984 (Ensembl)
UBE2FGeneProductENSG00000184182 (Ensembl)
UDP-glucuronosyl/UDP-glucosyltransferaseProteinIPR002213 (InterPro)
UGT1A10GeneProductENSG00000242515 (Ensembl)
UGT1A11PGeneProductENSG00000227846 (Ensembl)
UGT1A12PGeneProductENSG00000228949 (Ensembl)
UGT1A13PGeneProductENSG00000234143 (Ensembl)
UGT1A1GeneProductENSG00000242366 (Ensembl)
UGT1A2PGeneProductENSG00000228445 (Ensembl)
UGT1A3GeneProductENSG00000243135 (Ensembl)
UGT1A4GeneProductENSG00000244474 (Ensembl)
UGT1A5GeneProductENSG00000240224 (Ensembl)
UGT1A6GeneProductENSG00000167165 (Ensembl)
UGT1A7GeneProductENSG00000244122 (Ensembl)
UGT1A8GeneProductENSG00000241635 (Ensembl)
UGT1A9GeneProductENSG00000241119 (Ensembl)
USP40GeneProductENSG00000085982 (Ensembl)
acceptor beta-D-glucuronosideMetaboliteCHEBI:132367 (ChEBI)
actin cytoskeleton reorganizationQ14908027 (Wikidata)
actinQ185269 (Wikidata)
aminopeptidase activityQ14864885 (Wikidata)
bleeding Q166019 (Wikidata)
bone remodelingQ952019 (Wikidata)
cholesterolMetaboliteCHEBI:16113 (ChEBI)
clathrin-dependent endocytosisQ14876760 (Wikidata)
collagen VIComplexCPX-1736
cysteine proteaseQ419343 (Wikidata)
dTDPMetaboliteCHEBI:58369 (ChEBI)
dTMPMetaboliteCHEBI:63528 (ChEBI)
erythroblastQ3296909 (Wikidata)
extracellular matrixQ193825 (Wikidata)
galactosylceramideMetaboliteCHEBI:18390 (ChEBI)
glucuronate acceptorMetaboliteCHEBI:132368 (ChEBI)
heparan sulfate groupMetaboliteCHEBI:157750 (ChEBI)
histone deacetylase activity58196 (Rhea)
intercellular bridgeQ14873624 (Wikidata)
kynurenic acidMetaboliteQ642217 (Wikidata)
melanosome transportQ15320928 (Wikidata)
melanosomeQ1065756 (Wikidata)
microtubuleQ189933 (Wikidata)
mitotic spindle assemblyQ14912279 (Wikidata)
nitrateMetaboliteCHEBI:17632 (ChEBI)
oxidative stressQ898814 (Wikidata)
peroxynitriteMetaboliteCHEBI:25941 (ChEBI)
phosphatidylcholineMetaboliteCHEBI:57643 (ChEBI)
phosphatidylserineMetaboliteCHEBI:57262 (ChEBI)
positive regulation of smooth muscle cell proliferationQ14863701 (Wikidata)
protein ubiquitinationQ3547638 (Wikidata)
protein-serine-threonine kinasesQ4857068 (Wikidata)
proteinsMetaboliteCHEBI:36080 (ChEBI)
pyruvateMetaboliteCHEBI:15361 (ChEBI)
rRNA modification in the mitochondrionPathwayWP4099 (WikiPathways)
sensory perception of sound Q14865145 (Wikidata)
sterol metabolic processQ14599656 (Wikidata)
tubulinQ422492 (Wikidata)
vesicle transport along microtubuleQ14882513 (Wikidata)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5224"
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