Arsenic liver toxicity pathway (Homo sapiens)

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1KE155: Inadequate DNA repairOxidative damage responseArsenic carcinogenesis - reactive oxygen speciesKE1894: Chronic low grade systemic inflammationKE1395: Liver cancerNRF2 pathwayKE716: Increase, cell proliferation (hepatocytes)KE1940: Up-regulation of reactive oxygen speciesKE1194: Increased DNA damageDNA damage responseCell cycleKE1969: Increased oxidative stressTNF-alpha signaling pathwayKE1487:Binding, Thiol/seleno-proteins involved in protection against oxidative stress


Description

This is an adverse outcome pathway of arsenic toxicity on liver including key processes leading to arsenic induced liver cancer.

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Ontology Terms

 

Bibliography

  1. Angrish MM, Allard P, McCullough SD, Druwe IL, Helbling Chadwick L, Hines E, Chorley BN; ''Epigenetic Applications in Adverse Outcome Pathways and Environmental Risk Evaluation.''; Environ Health Perspect, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129377view09:48, 27 March 2024MkutmonOntology Term : 'disease pathway' added !
128630view03:16, 17 February 2024EweitzEconomize layout, standardize case
128617view00:05, 17 February 2024EweitzOntology Term : 'hepatocyte' added !
128616view00:05, 17 February 2024EweitzOntology Term : 'liver cancer' added !
128615view00:04, 17 February 2024EweitzModified title
128606view20:25, 15 February 2024Marvin M2Added reference
122969view12:43, 5 June 2022ZDLech
122896view12:00, 30 May 2022ZDLechChanged ID for pathway: Arsenic carcinogenesis - reactive oxygen species
122862view17:14, 25 May 2022ZDLechAdded Key Event 155
122694view13:23, 3 May 2022ZDLechPathway change under KE1487
122660view15:03, 27 April 2022ZDLechRemoved arsenic node add added arrows to the interactions
122656view13:16, 26 April 2022ZDLechNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Arsenic carcinogenesis - reactive oxygen speciesPathwayWP5233 (WikiPathways)
Cell cyclePathwayWP179 (WikiPathways)
DNA damage responsePathwayWP707 (WikiPathways)
KE1194: Increased DNA damageKey Event1194 (AOP-Wiki KE)
KE1395: Liver cancerKey Event1395 (AOP-Wiki KE)
KE1487:Binding, Thiol/seleno-proteins involved in protection against oxidative stressKey Event1487 (AOP-Wiki KE)
KE155: Inadequate DNA repairKey Event155 (AOP-Wiki KE)
KE1894: Chronic low grade systemic inflammationKey Event1894 (AOP-Wiki KE)
KE1940: Up-regulation of reactive oxygen speciesKey Event1940 (AOP-Wiki KE)
KE1969: Increased oxidative stressKey Event1969 (AOP-Wiki KE)
KE716: Increase, cell proliferation (hepatocytes)Key Event716 (AOP-Wiki KE)
NRF2 pathwayPathwayWP2884 (WikiPathways)
Oxidative damage responsePathwayWP3941 (WikiPathways)
TNF-alpha signaling pathwayPathwayWP231 (WikiPathways)

Annotated Interactions

No annotated interactions

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