Nephrotoxcicity adverse outcome pathway (Homo sapiens)
From WikiPathways
Description
Adverse outcome pathway showing the events of nephrotoxicity leading to tubular cell injury and death.
Quality Tags
Ontology Terms
Bibliography
- Perazella MA, Rosner MH; ''Drug-Induced Acute Kidney Injury.''; Clin J Am Soc Nephrol, 2022 PubMed Europe PMC Scholia
- Manohar S, Leung N; ''Cisplatin nephrotoxicity: a review of the literature.''; J Nephrol, 2018 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
Apoptosis modulation and signaling | Pathway | WP1772 (WikiPathways) | |
Autophagy | Pathway | WP4923 (WikiPathways) | |
Cytokines and inflammatory response | Pathway | WP530 (WikiPathways) | |
DNA damage response | Pathway | WP707 (WikiPathways) | |
DNA repair pathways, full network | Pathway | WP4946 (WikiPathways) | |
Electron transport chain: OXPHOS system in mitochondria | Pathway | WP111 (WikiPathways) | |
Ferroptosis | Pathway | WP4313 (WikiPathways) | |
Inflammatory response pathway | Pathway | WP453 (WikiPathways) | |
KE1115: Increased, Reactive oygen species | Event | 1115 (AOP-Wiki KE) | |
KE1194: Increase, DNA damage | Event | 1194 (AOP-Wiki KE) | |
KE1262: Apoptosis | Event | 1262 (AOP-Wiki KE) | |
KE1496: Increased, secretion of proinflammatory mediators | Event | 1496 (AOP-Wiki KE) | |
KE1633: Increase in inflammation | Event | 1633 (AOP-Wiki KE) | |
KE1815: Activation of ER stress | Event | 1815 (AOP-Wiki KE) | |
KE1848: Toll Like Receptor (TLR) dysregulation | Event | 1848 (AOP-Wiki KE) | |
KE1923: Altered gene expression, P53 dependent apoptosis pathway | Event | 1923 (AOP-Wiki KE) | |
KE1968: Increase, mitochondrial dysfunction | Event | 1968 (AOP-Wiki KE) | |
KE55: Cell injury/death | Event | 55 (AOP-Wiki KE) | |
KE814: Occurence, kidney toxicity | Event | 814 (AOP-Wiki KE) | |
Overview of proinflammatory and profibrotic mediators | Pathway | WP5095 (WikiPathways) | |
Oxidative damage response | Pathway | WP3941 (WikiPathways) | |
Oxidative stress response | Pathway | WP408 (WikiPathways) | |
RIPK1-mediated regulated necrosis | Pathway | WP5022 (WikiPathways) | |
SLC22A2 | GeneProduct | ENSG00000112499 (Ensembl) | |
SLC31A1 | GeneProduct | ENSG00000136868 (Ensembl) | |
TLR4 signaling and tolerance | Pathway | WP3851 (WikiPathways) | |
Toll-like receptor signaling pathway | Pathway | WP75 (WikiPathways) | |
Unfolded protein response | Pathway | WP4925 (WikiPathways) | |
p53 transcriptional gene network | Pathway | WP4963 (WikiPathways) |
Annotated Interactions
No annotated interactions