Arsenic metabolism and reactive oxygen species generation (Homo sapiens)

Description

Arsenic induced ROS formation may lead to carcinogenic effects.

View approved pathways at the new wikipathways.org.

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Revision	Action	Time	User	Comment
129331	view	09:06, 27 March 2024	Mkutmon	Ontology Term : 'classic metabolic pathway' added !
123583	view	12:53, 4 August 2022	Fehrhart	Ontology Term : 'cancer' added !
123560	view	18:03, 3 August 2022	Egonw	Typed a datanode
122729	view	13:19, 6 May 2022	ZDLech	Added references and fixed interactions.
122714	view	14:14, 4 May 2022	ZDLech	Change of shape type for node: Activation of oncogenic pathways
122713	view	14:10, 4 May 2022	ZDLech	New pathway

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Name	Type	Database reference
AS3MT	GeneProduct	ENSG00000214435 (Ensembl)
ATP1A1	GeneProduct	ENSG00000163399 (Ensembl)
Activation of oncogenic pathways
CAT	GeneProduct	ENSG00000121691 (Ensembl)
COA3	GeneProduct	ENSG00000183978 (Ensembl)
DMA (III)	Metabolite	161508 (Chemspider)
DMA (V)	Metabolite	2418 (Chemspider)
GSH	Metabolite	CHEBI:16856 (ChEBI)
GSSG	Metabolite	CHEBI:17858 (ChEBI)
GSTO1	GeneProduct	ENSG00000148834 (Ensembl)
H2O2	Metabolite	16240 (ChEBI)
H2O	Metabolite	CHEBI:15377 (ChEBI)
MMA (III)	Metabolite	141846 (Chemspider)
MMA (V)	Metabolite	8604 (Chemspider)
MT-ND1	GeneProduct	ENSG00000198888 (Ensembl)
Mitochondrial dysfunction
O2·–	Metabolite	18421 (ChEBI)
OXPHOS	Pathway	WP111 (WikiPathways)
ROS	Metabolite	26523 (ChEBI)
S-adenosylmethionine	Metabolite	CHEBI:15414 (ChEBI)
SAH	Metabolite	CHEBI:16680 (ChEBI)
SDHA	GeneProduct	ENSG00000073578 (Ensembl)
SOD1	GeneProduct	ENSG00000142168 (Ensembl)
SOD2	GeneProduct	ENSG00000112096 (Ensembl)
UQCRFS1	GeneProduct	ENSG00000169021 (Ensembl)
VDAC1	GeneProduct	ENSG00000213585 (Ensembl)
arsenic(3+)	Metabolite	CHEBI:35828 (ChEBI)
arsenic(5+)	Metabolite	CHEBI:35829 (ChEBI)
arsenic	Metabolite	CHEBI:27563 (ChEBI)

No annotated interactions