Serotonin reuptake inhibitor response (Daphnia magna)

From WikiPathways

Jump to: navigation, search
1sphingosinecis-aconitatePfkD-glucose-1-pGlyPStarch and sucrose metabolismglycogenUDP-glucoseUGPPyruvateGlycolysisAcetyl-CoAcitrateFbp3-oxo-hexanoyl-CoAFatty acidthiolaseLipid metabolismTryptophan metabolismtryptaminetryptaminetryptamineDdcDdcisocitrateoxalosuccinate2-oxoglutarateoxaloacetateATPCAconAconldhldhceramideGlycospingolipidsbiosynthesisMetaboliteSphingolipids biogenesisGlcT-1cDASElace


Description

Various biological pathways affected in response to exposure to serotonin reuptake inhibitors. After exposure the genes lace, cDASE, GlcT-1, ldh, Acon, Ddc, Fbp, and thiolase are upregulated, while Pfk, UGP, and ATPC are downregulated.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Campos B, Garcia-Reyero N, Rivetti C, Escalon L, Habib T, Tauler R, Tsakovski S, Piña B, Barata C; ''Identification of metabolic pathways in Daphnia magna explaining hormetic effects of selective serotonin reuptake inhibitors and 4-nonylphenol using transcriptomic and phenotypic responses.''; Environ Sci Technol, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124088view13:30, 18 September 2022EgonwAdded metabolite identifiers
124073view19:50, 15 September 2022EgonwAdded gene identifiers from the supplementary info
124072view16:53, 15 September 2022EgonwModified description
124071view16:51, 15 September 2022EgonwAdded the remaining entities
124070view16:29, 15 September 2022EgonwModified description
122864view18:32, 25 May 2022MkutmonOntology Term : 'serotonin metabolic pathway' added !
122833view18:03, 21 May 2022Egonwno caps
122832view18:02, 21 May 2022EgonwHalfway the figure
122831view17:43, 21 May 2022EgonwManually set the species (PV 3 does not know it yet)
122830view17:42, 21 May 2022EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Metabolite
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
3-oxo-hexanoyl-CoAMetaboliteCHEBI:27648 (ChEBI)
ATPCGeneProduct
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
AconGeneProduct17864292 (Entrez Gene)
D-glucose-1-pMetaboliteCHEBI:16077 (ChEBI)
DdcGeneProduct7768790 (Entrez Gene)
Fatty acidMetaboliteCHEBI:35366 (ChEBI)
FbpGeneProduct45550998 (Entrez Gene)
GlcT-1GeneProduct
GlyPGeneProduct91081301 (Entrez Gene)
GlycolysisPathway
Glycospingolipids biosynthesisPathway
Lipid metabolismPathway
MetaboliteMetabolite
PfkGeneProduct91088313 (Entrez Gene)
PyruvateMetaboliteCHEBI:15361 (ChEBI)
Sphingolipids biogenesisPathway
Starch and sucrose metabolismPathway
Tryptophan metabolismPathway
UDP-glucoseMetaboliteCHEBI:18066 (ChEBI)
UGPGeneProduct47086583 (Entrez Gene)
cDASEGeneProduct
ceramideMetaboliteCHEBI:17761 (ChEBI)
cis-aconitateMetaboliteCHEBI:32805 (ChEBI)
citrateMetaboliteCHEBI:30769 (ChEBI)
glycogenMetaboliteCHEBI:28087 (ChEBI)
isocitrateMetaboliteCHEBI:16087 (ChEBI)
laceGeneProduct
ldhGeneProduct
oxaloacetateMetaboliteCHEBI:16452 (ChEBI)
oxalosuccinateMetaboliteCHEBI:153066 (ChEBI)
sphingosineMetaboliteCHEBI:16393 (ChEBI)
thiolaseGeneProduct156369857 (Entrez Gene)
tryptamineMetaboliteCHEBI:16765 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5237"
Personal tools