Serotonin reuptake inhibitor response (Daphnia magna)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none cis-aconitatePfkGlyPsphingosineD-glucose-1-pStarch and sucrose metabolismglycogenUDP-glucoseUGPPyruvateGlycolysisAcetyl-CoAcitrateFbp3-oxo-hexanoyl-CoAFatty acidthiolaseLipid metabolismTryptophan metabolismtryptaminetryptaminetryptamineDdcDdcisocitrateoxalosuccinate2-oxoglutarateoxaloacetateATPCAconAconldhldhceramideGlycospingolipidsbiosynthesisMetaboliteSphingolipids biogenesisGlcT-1cDASElaceName: Serotonin reuptake inhibitor responseOrganism: Daphnia magna


Description

Various biological pathways affected in response to exposure to serotonin reuptake inhibitors. After exposure the genes lace, cDASE, GlcT-1, ldh, Acon, Ddc, Fbp, and thiolase are upregulated, while Pfk, UGP, and ATPC are downregulated.

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Quality Tags

Image:Curated.pngApproved version
Image:Unconnected.pngFix interactions
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : cancer pathway microRNA pathway
Disease : ovarian cancer
Cell Type : neoplastic cell
 

Bibliography

  1. Campos B, Garcia-Reyero N, Rivetti C, Escalon L, Habib T, Tauler R, Tsakovski S, Piña B, Barata C; ''Identification of metabolic pathways in Daphnia magna explaining hormetic effects of selective serotonin reuptake inhibitors and 4-nonylphenol using transcriptomic and phenotypic responses.''; Environ Sci Technol, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124088
Approved
view13:30, 18 September 2022EgonwAdded metabolite identifiers
124073view19:50, 15 September 2022EgonwAdded gene identifiers from the supplementary info
124072view16:53, 15 September 2022EgonwModified description
124071view16:51, 15 September 2022EgonwAdded the remaining entities
124070view16:29, 15 September 2022EgonwModified description
122864view18:32, 25 May 2022MkutmonOntology Term : 'serotonin metabolic pathway' added !
122833view18:03, 21 May 2022Egonwno caps
122832view18:02, 21 May 2022EgonwHalfway the figure
122831view17:43, 21 May 2022EgonwManually set the species (PV 3 does not know it yet)
122830view17:42, 21 May 2022EgonwNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
Metabolite
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
3-oxo-hexanoyl-CoAMetaboliteCHEBI:27648 (ChEBI)
ATPCGeneProduct
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
AconGeneProduct17864292 (Entrez Gene)
D-glucose-1-pMetaboliteCHEBI:16077 (ChEBI)
DdcGeneProduct7768790 (Entrez Gene)
Fatty acidMetaboliteCHEBI:35366 (ChEBI)
FbpGeneProduct45550998 (Entrez Gene)
GlcT-1GeneProduct
GlyPGeneProduct91081301 (Entrez Gene)
GlycolysisPathway
Glycospingolipids biosynthesisPathway
Lipid metabolismPathway
MetaboliteMetabolite
PfkGeneProduct91088313 (Entrez Gene)
PyruvateMetaboliteCHEBI:15361 (ChEBI)
Sphingolipids biogenesisPathway
Starch and sucrose metabolismPathway
Tryptophan metabolismPathway
UDP-glucoseMetaboliteCHEBI:18066 (ChEBI)
UGPGeneProduct47086583 (Entrez Gene)
cDASEGeneProduct
ceramideMetaboliteCHEBI:17761 (ChEBI)
cis-aconitateMetaboliteCHEBI:32805 (ChEBI)
citrateMetaboliteCHEBI:30769 (ChEBI)
glycogenMetaboliteCHEBI:28087 (ChEBI)
isocitrateMetaboliteCHEBI:16087 (ChEBI)
laceGeneProduct
ldhGeneProduct
oxaloacetateMetaboliteCHEBI:16452 (ChEBI)
oxalosuccinateMetaboliteCHEBI:153066 (ChEBI)
sphingosineMetaboliteCHEBI:16393 (ChEBI)
thiolaseGeneProduct156369857 (Entrez Gene)
tryptamineMetaboliteCHEBI:16765 (ChEBI)

Annotated Interactions

No annotated interactions

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