Acetylcholine synthesis (Homo sapiens)

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1Synaptic cleftCytosolCHKAAcetylcholineCytidine diphosphate cholinePDHA2CHATAcetyl CoAPCYT1ACholinePDHA1ACHEPhosphatidylethanolaminePhosphorylcholinePEMTAcetateGlycerophosphocholinePyruvatePhosphatidylcholineCholineGlycolysis


Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.

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Ontology Terms



  1. Blusztajn JK, Wurtman RJ; ''Choline and cholinergic neurons.''; Science, 1983 PubMed Europe PMC Scholia


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128074view00:50, 24 January 2024EweitzExtract pathway node from compound metabolite-pathway; omit decorative asterisks from text labels
128072view00:40, 24 January 2024EweitzOntology Term : 'cholinergic neuron' added !
120525view01:53, 11 December 2021EweitzFix case
116805view10:10, 14 May 2021EweitzModified title
106814view13:29, 17 September 2019MaintBotHMDB identifier normalization
79855view14:00, 20 April 2015Mkutmonconversion of choline to phosphorylcholine - should not start from the transport interaction
79212view19:45, 12 March 2015KhanspersReverted to version '15:29, 6 October 2014' by Khanspers
79143view05:36, 5 March 2015KhanspersAdded conversion comment
77669view15:29, 6 October 2014Mkutmonfixed unconnected lines
76269view18:15, 25 June 2014MaintBotconnected interactions, switched to mim-catalysis, added graphical lines
72538view15:11, 19 November 2013EgonwWider boxes so that the full label is visible.
72530view07:28, 19 November 2013AnweshaConnected Interactions
72513view18:16, 18 November 2013AriuttaReverted to version '17:58, 8 July 2013' by Ariutta
72348view01:06, 11 November 2013Ariutta
69052view17:58, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
63138view19:15, 8 May 2013MaintBotUpdating GPML version
44939view12:28, 6 October 2011MartijnVanIerselOntology Term : 'acetylcholine metabolic pathway' added !
41084view23:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
38919view21:06, 24 September 2010Khanspers
35059view10:55, 11 February 2010Thomasadded literature reference
34458view18:25, 10 December 2009MaintBotAutomatic update of empty xrefs
33205view19:29, 5 November 2009KhanspersPeriodical save, work in progress
32140view13:57, 14 August 2009MaintBotFixed group labels
29049view13:05, 27 March 2009MartijnVanIerselModified description
29048view12:57, 27 March 2009MartijnVanIerselFixed phosphorylcholine
29046view12:54, 27 March 2009MartijnVanIerselMetabolized labels
21790view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Acetylcholine Synthesis]] moved to [[Pathway:WP528]]: Moved to stable identifier
16330view12:19, 18 June 2008HubertModified description
15387view22:20, 27 May 2008Khanspersconnectors
14388view19:19, 22 May 2008KhanspersAdded connectors
14386view19:02, 22 May 2008KhanspersPeriodical save, work in progress
14384view18:52, 22 May 2008KhanspersPeriodical save, work in progress
13035view11:10, 17 May 2008MaintBotautomated metabolite conversion
7878view13:46, 7 January 2008MaintBot[[Pathway:Human:Acetylcholine Synthesis]] moved to [[Pathway:Homo sapiens:Acetylcholine Synthesis]]: Renaming species
7564view16:00, 18 December 2007MaintBotfixed category names
7325view12:42, 4 November 2007MaintBotAdded categories to GPML
6290view22:17, 22 May 2007A.Kwatest

External references


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NameTypeDatabase referenceComment
ACHEGeneProduct43 (Entrez Gene)
AcetateMetabolite64-19-7 (CAS)
Acetyl CoAMetabolite72-89-9 (CAS)
AcetylcholineMetabolite51-84-3 (CAS)
CHATGeneProduct1103 (Entrez Gene)
CHKAGeneProduct1119 (Entrez Gene)
CholineMetabolite62-49-7 (CAS)
Cytidine diphosphate cholineMetaboliteHMDB0001413 (HMDB)
GlycerophosphocholineMetabolite28319-77-9 (CAS)
GlycolysisPathwayWP534 (WikiPathways)
PCYT1AGeneProduct5130 (Entrez Gene)
PDHA1GeneProduct5160 (Entrez Gene)
PDHA2GeneProduct5161 (Entrez Gene)
PEMTGeneProduct10400 (Entrez Gene)
PhosphatidylcholineMetaboliteHMDB0000564 (HMDB)
PhosphatidylethanolamineMetaboliteHMDB0060501 (HMDB)
PhosphorylcholineMetaboliteHMDB0001565 (HMDB)
PyruvateMetaboliteHMDB0000243 (HMDB)

Annotated Interactions

No annotated interactions

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