Immune infiltration in pancreatic cancer (Homo sapiens)
From WikiPathways
Description
Immune cell infiltration in pancreatic cancer. Various factors are secreted in the tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) that can either stimulate or inhibit PDAC development. Alteration of PDAC development by immune cells can be direct and/or indirect.
Used cell name abbreviations: MDSC = myeloid-derived suppressor cell, Treg = regulatory T cell, CAF = cancer associated fibroblast, PSC = pancreatic stellate cell, Th = CD4+ T helper cell.
Quality Tags
Ontology Terms
Bibliography
View all... |
- Zhang R, Liu Q, Peng J, Wang M, Li T, Liu J, Cui M, Zhang X, Gao X, Liao Q, Zhao Y; ''CXCL5 overexpression predicts a poor prognosis in pancreatic ductal adenocarcinoma and is correlated with immune cell infiltration.''; J Cancer, 2020 PubMed Europe PMC Scholia
- Goulart MR, Stasinos K, Fincham REA, Delvecchio FR, Kocher HM; ''T cells in pancreatic cancer stroma.''; World J Gastroenterol, 2021 PubMed Europe PMC Scholia
- Ma X, Wu D, Zhou S, Wan F, Liu H, Xu X, Zhao Y, Tang M; ''The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway.''; Oncol Rep, 2016 PubMed Europe PMC Scholia
- Masucci MT, Minopoli M, Carriero MV; ''Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy.''; Front Oncol, 2019 PubMed Europe PMC Scholia
- ''''; , PubMed Europe PMC Scholia
- Fan JQ, Wang MF, Chen HL, Shang D, Das JK, Song J; ''Current advances and outlooks in immunotherapy for pancreatic ductal adenocarcinoma.''; Mol Cancer, 2020 PubMed Europe PMC Scholia
- Liu X, Xu J, Zhang B, Liu J, Liang C, Meng Q, Hua J, Yu X, Shi S; ''The reciprocal regulation between host tissue and immunecells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications.''; Mol Cancer, 2019 PubMed Europe PMC Scholia
- Ren B, Cui M, Yang G, Wang H, Feng M, You L, Zhao Y; ''Tumor microenvironment participates in metastasis of pancreatic cancer.''; Mol Cancer, 2018 PubMed Europe PMC Scholia
- Cui R, Yue W, Lattime EC, Stein MN, Xu Q, Tan XL; ''Targeting tumor-associated macrophages to combat pancreatic cancer.''; Oncotarget, 2016 PubMed Europe PMC Scholia
- Sideras K, Braat H, Kwekkeboom J, van Eijck CH, Peppelenbosch MP, Sleijfer S, Bruno M; ''Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies.''; Cancer Treat Rev, 2014 PubMed Europe PMC Scholia
- Liu B, Jia Y, Ma J, Wu S, Jiang H, Cao Y, Sun X, Yin X, Yan S, Shang M, Mao A; ''Tumor-associated macrophage-derived CCL20 enhances the growth and metastasis of pancreatic cancer.''; Acta Biochim Biophys Sin (Shanghai), 2016 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
View all... |
Annotated Interactions
No annotated interactions