Axon guidance (Homo sapiens)

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Neuron1, 2Guidance cuesNullRegulation of actin cytoskeletonMAPK signaling pathwayDCCLRRC4CCFL1RHOAPLXNA1NRP1L1CAMSEMA3AFESFYNCDK5PLCG1DPYSL5DPYSL2PLXNB2SEMA4FSEMA5BSEMA6CSEMA7AMETPLXNC1PTK2ITGB1PTK2RAC1PAK4RRASRND1ARHGEF12RHOASRCRAF1MAPK1SHHPTCH1SMOBOCSMOPRKCAILKWNT5AFZD3RYKTRPC1CAMK2AWNT4UNC5DFZD3PIK3CAPDPK1PRKCZPARD3PARD6ATRPC1PPP3CANTN1BMPR2BMPR1BBMP7GDF7SHHCFL1LIMK1CFL1NTN3CDC42NCK2CDC42GSK3BFYNGSK3BNTN4DCCLRRC4PTK2NCK1PTPN11NFATC2PPAK4SRCFYNRHOATRPC1ROCK1RAC1ABLIM3NEO1LRIG2NTNG1RGMAPTK2ARHGEF12RHOAROCK1MYL12BEPHA2EPHB1ABL1NTNG2RASA1NGEFENAHHRASMAPK1RAC1CDC42RHOAROCK1EFNA1EFNB1CXCR4CXCR4CXCL12PAK4RASA1FYNNCK2PTK2RGS3GNAI1PPP3CAGNAI1ROBO2ROBO1SLIT1SLIT2SLIT3ROBO3ABL1NFATC2ENAHSRGAP2PAK4RAC1RAC1PAK4RHODRND1LIMK1Ca2+Ca2+Ca2+Ca2+Axon outgrowthAxon repulsionTranscriptionAttractionWnt signaling pathwayCytokine-cytokine receptor interactionRegulation of actin cytoskeletonRepulsionAttractionAxon attractionMicrotubule organizationRegulation of actin cytoskeletonRegulation of actin cytoskeletonMAPK signaling pathway


Description

Axon Guidance. Pathway took from KEGG (https://www.kegg.jp/entry/map04360)

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Quality Tags

Ontology Terms

 

Bibliography

  1. Goto-Silva L, Martins M, Murillo JR, Souza LRQ, Vitória G, Oliveira JT, Nascimento JM, Loiola EC, Nogueira FCS, Domont GB, Guimarães MZP, Tovar-Moll F, Rehen SK, Junqueira M; ''Quantitative profiling of axonal guidance proteins during the differentiation of human neurospheres.''; Biochim Biophys Acta Proteins Proteom, 2021 PubMed Europe PMC Scholia
  2. ''''; https://www.kegg.jp/entry/map04360,

History

View all...
CompareRevisionActionTimeUserComment
129446view15:59, 20 April 2024EweitzModified title
129395view17:39, 8 April 2024Khanspersadded KEGG pathway as reference
129394view17:38, 8 April 2024KhanspersOntology Term : 'signaling pathway pertinent to the brain and nervous system' added !
129393view17:37, 8 April 2024KhanspersOntology Term : 'neuron' added !
129392view17:34, 8 April 2024Khanspersadded xrefs, updated interactions, removed redundant and empty nodes
129389view00:36, 6 April 2024Khanspersupdated interactions to elbows, changed pathway nodes to labels
129388view00:21, 6 April 2024Khanspersremoved fill color for nodes and cell shapes, updated pathway and metabolite nodes
124308view16:09, 12 October 2022LLadeiraModified title
124307view16:06, 12 October 2022LLadeiraNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1ProteinENSG00000097007 (Ensembl)
ABLIM3ProteinO94929 (Uniprot-TrEMBL)
ARHGEF12ProteinNM_015313 (RefSeq)
BMP7Protein1074 (HGNC Accession number)
BMPR1BProtein658 (Entrez Gene)
BMPR2Protein659 (Entrez Gene)
BOCProtein91653 (Entrez Gene)
CAMK2AProtein1460 (HGNC Accession number)
CDC42Protein998 (Entrez Gene)
CDK5ProteinCDK5 (HGNC)
CFL1ProteinENSG00000172757 (Ensembl)
CXCL12ProteinP48061 (Uniprot-TrEMBL)
CXCR4ProteinNM_001008540 (RefSeq)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cytokine-cytokine receptor interactionPathwayhsa04060 (KEGG Pathway)
DCCProteinNM_005215 (RefSeq)
DPYSL2ProteinNM_001386 (RefSeq)
DPYSL5ProteinQ9BPU6 (Uniprot-TrEMBL)
EFNA1Protein1942 (Entrez Gene)
EFNB1ProteinP98172 (Uniprot-TrEMBL)
ENAHProteinNM_018212 (RefSeq)
EPHA2ProteinEPHA2 (HGNC)
EPHB1ProteinEPHB1 (HGNC)
FESProteinNM_002005 (RefSeq)
FYNProteinFYN (HGNC)
FZD3ProteinFZD3 (HGNC)
GDF7ProteinGDF7 (HGNC)
GNAI1ProteinNM_002069 (RefSeq)
GSK3BProteinGSK3B (HGNC)
HRASProteinENSG00000174775 (Ensembl)
ILKProteinENSG00000166333 (Ensembl)
ITGB1ProteinNM_002211 (RefSeq)
L1CAMProteinP32004 (Uniprot-TrEMBL)
LIMK1Protein6613 (HGNC Accession number)
LRIG2Protein9860 (Entrez Gene)
LRRC4Protein15586 (HGNC Accession number)
LRRC4CProteinENSG00000148948 (Ensembl)
MAPK signaling pathwayPathwayhsa04010 (KEGG Pathway)
MAPK1ProteinENSG00000100030 (Ensembl)
METProteinMET (HGNC)
MYL12BProtein103910 (Entrez Gene)
NCK1ProteinENSG00000158092 (Ensembl)
NCK2Protein7665 (HGNC Accession number)
NEO1Protein7754 (HGNC Accession number)
NFATC2Protein7776 (HGNC Accession number)
NGEFProteinQ8N5V2 (Uniprot-TrEMBL)
NRP1Protein8829 (Entrez Gene)
NTN1Protein8029 (HGNC Accession number)
NTN3Protein4917 (Entrez Gene)
NTN4Protein59277 (Entrez Gene)
NTNG1Protein23319 (HGNC Accession number)
NTNG2ProteinNM_032536 (RefSeq)
PAK4Protein16059 (HGNC Accession number)
PARD3ProteinPARD3 (HGNC)
PARD6AProteinENSG00000102981 (Ensembl)
PDPK1ProteinENSG00000140992 (Ensembl)
PIK3CAProtein8975 (HGNC Accession number)
PLCG1Protein9065 (HGNC Accession number)
PLXNA1ProteinENSG00000114554 (Ensembl)
PLXNB2Protein9104 (HGNC Accession number)
PLXNC1Protein9106 (HGNC Accession number)
PPP3CAProtein9314 (HGNC Accession number)
PRKCAProteinPRKCA (HGNC)
PRKCZProtein5590 (Entrez Gene)
PTCH1ProteinNM_000264 (RefSeq)
PTK2Protein9611 (HGNC Accession number)
PTPN11Protein9644 (HGNC Accession number)
RAC1Protein5879 (Entrez Gene)
RAF1ProteinENSG00000132155 (Ensembl)
RASA1ProteinNM_002890 (RefSeq)
RGMAProtein56963 (Entrez Gene)
RGS3Protein9999 (HGNC Accession number)
RHOAProtein667 (HGNC Accession number)
RHODProteinO00212 (Uniprot-TrEMBL)
RND1Protein18314 (HGNC Accession number)
ROBO1ProteinQ9Y6N7 (Uniprot-TrEMBL)
ROBO2ProteinNM_001128929 (RefSeq)
ROBO3ProteinNM_022370 (RefSeq)
ROCK1Protein6093 (Entrez Gene)
RRASProteinRRAS (HGNC)
RYKProteinENSG00000163785 (Ensembl)
Regulation of actin cytoskeletonPathwayhsa04810 (KEGG Pathway)
SEMA3AProteinNM_006080 (RefSeq)
SEMA4FProtein10734 (HGNC Accession number)
SEMA5BProtein54437 (Entrez Gene)
SEMA6CProteinENSG00000143434 (Ensembl)
SEMA7AProtein8482 (Entrez Gene)
SHHProteinQ15465 (Uniprot-TrEMBL)
SLIT1ProteinSLIT1 (HGNC)
SLIT2Protein9353 (Entrez Gene)
SLIT3ProteinSLIT3 (HGNC)
SMOProtein11119 (HGNC Accession number)
SRCProteinP12931 (Uniprot-TrEMBL)
SRGAP2ProteinNM_015326 (RefSeq)
TRPC1ProteinTRPC1 (HGNC)
UNC5DProteinQ6UXZ4 (Uniprot-TrEMBL)
WNT4ProteinENSG00000162552 (Ensembl)
WNT5AProteinWNT5A (HGNC)
Wnt signaling pathwayPathwayhsa04310 (KEGG Pathway)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5289"
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