TROP2 regulatory signaling (Homo sapiens)

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Up-regulationProteinmRNAProteinmRNAProteinmRNA Down-regulationProtein Components of complex unknownCa2+ Calcium ionProteinProtein Proteins in complexProteinXXXX Proteins with/without phosphositeFACECYNUTROP2-ICD TROP2 intracellular domain Protein-protein interaction Kinase-substrate reaction Leads to through unknown mechanisms or indication of studied cell types Leads to decrease in activity or phosphorylation at sites Translocation of proteins Transcriptional or translational regulation of gene/protein expression Cytoplasm Cell leading edges Focal adhesions Nucleus Figure Legend2TACSTD22931, 401238242514, 39540EnhanceddirectionalmigrationIn GBC-SD andSGC-996 cellsIntracellular(TROP2-ICD)In LNCaP cells and xenograftsleading toDNA condensationand decrease inhistone methylationTROP2dimerTROP2 prevents IGF1 & MDKbinding to IGF1R &ALK, respectively, bycompetitive bindingInMTE-4-14 cellsInHUVECsIn the leading edges of prostate cancer cells plated on FN InHCT116cellsEnhancesGC cell tolerance tochemotherapy3, 29Ca2+CLDN1CLDN736PARP1CD56PSMAPSASOX2MYCTP63OCT3/4ARUpregulatedin VCaP cells &downregulatedin LNCaP cells& 22Rv1 cells SYPInLNCaPandPC-3cells 3636ABCC1NOTCH1In BGC-823 andHGC27 cells 444416CDKN2A1616Cell cycleregulation16PRKAA2PIK3R1PAKT1S473T3083313, 33, 3413Proliferation and migrationof HN6, SCC4,MG63, KM12SMMNNG/HOS, U2OS,MTE4-14 andPC-9/GR cells10, 13, 33MMP2In 8505C,K1 andFT-133 cells37AP13724, 37MAPK8T183MAPK9Y185T183Y185MAPK1MAPK3Y187T185T202Y20414, 19, 25, 32, 373737PTENS380PDPK134343434IGF12, 112, 11MDK113030, 38PRKCAPRKCD38CASP325In A549NSCLCs2525MMP13PECAM1EGFRY1173In A549NSCLCs25ACVRL1Y1604IGF1RY1135Y1150Y1151Y113611111111InHeLacells11, 321111RAC1GTP4040ITGB131, 40ITGA5TLN1TLN14014, 32CREB1S133STAT1Y701RB1S780NFKB1SRC24PTK2Y416Y397InPC3-2cellsJUNIn FT-133,FADU andMTE-4-14 cells22ADAM10 TACSTD2S32220CDH1Affinity:CLDN7>CLDN1BCL27, 23BAXInA2780,Hela and C33AcellsCTNNB15, 19FN1VIMCDH1Induces EMTin MGC803cells7, 19CDK4InHelaandC33Acells19In LNCaP &TRAMP C2 cells35CCND1CCNE1CDK2CDKN1BInPanc02, Hela and C33AcellsJAK2Y1007STAT3Y1008Y705S727666In LN-229and U87-MGcellsPSEN2ADAM17 1212TACSTD2TROP2-ICD12PSEN1 ADAM17 1212, 1512In LNCaPcells 12357Upregulatedin Panc02, Hela,C33ATRAMP C2 &HEP2 cells anddown-regulatedin MTE-4-14 cells73636363636InLNCaP,PC-3,VCaP,DU-145cells36In LNCaP cells and xenografts,PC-3, andVCaP cells363636CTNNB1365222In TROP2-overexpressingH1299,CL1-0and H23 lungcancer cellsIn TROP2-overexpressingH1299,CL1-0and H23 lungcancer cells22InH1299 andH23 cellsIGF2R10IGF2101010RACK1242424342414, 323632CYNUCYNUFACEIn MTE-4-14 cells323214, 3225 TROP2 Regulatory signaling networkPAK4S474404012NUMB12In v-SRC PECcells 34


Description

Schematic representation of TROP2 mediated signaling mechanism in different types of cancers

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Bibliography

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History

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CompareRevisionActionTimeUserComment
126494view20:24, 9 May 2023Khanspersconverted interactions in legend to graphical lines, added xref for Ca2+
124970view20:26, 10 January 2023KhanspersOntology Term : 'signaling pathway' added !
124847view21:13, 14 December 2022EweitzModified title
124560view00:44, 9 November 2022EweitzModified title
124536view08:11, 7 November 2022Rex D A BNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCC1Protein4363 (Entrez Gene)
ACVRL1Protein94 (Entrez Gene)
ADAM10 Protein102 (Entrez Gene)
ADAM17 Protein6868 (Entrez Gene)
AKT1Protein4070 (Entrez Gene)
AP1Protein4070 (Entrez Gene)
ARProtein9076 (Entrez Gene)
BAXProtein581 (Entrez Gene)
BCL2Protein596 (Entrez Gene)
CASP3Protein9076 (Entrez Gene)
CCND1Protein595 (Entrez Gene)
CCNE1Protein898 (Entrez Gene)
CD56Protein9076 (Entrez Gene)
CDH1Protein999 (Entrez Gene)
CDK2Protein1017 (Entrez Gene)
CDK4Protein1019 (Entrez Gene)
CDKN1BProtein1027 (Entrez Gene)
CDKN2AProtein1029 (Entrez Gene)
CLDN1Protein9076 (Entrez Gene)
CLDN7Protein1366 (Entrez Gene)
CREB1Protein3725 (Entrez Gene)
CTNNB1Protein1499 (Entrez Gene)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
EGFRProtein1956 (Entrez Gene)
FN1Protein2335 (Entrez Gene)
IGF1Protein3479 (Entrez Gene)
IGF1RProtein3480 (Entrez Gene)
IGF2Protein3481 (Entrez Gene)
IGF2RProtein3482 (Entrez Gene)
ITGA5Protein3678 (Entrez Gene)
ITGB1Protein3688 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
MAPK1Protein9076 (Entrez Gene)
MAPK3Protein9076 (Entrez Gene)
MAPK8Protein9076 (Entrez Gene)
MAPK9Protein9076 (Entrez Gene)
MDKProtein4192 (Entrez Gene)
MMP13Protein4322 (Entrez Gene)
MMP2Protein1111 (Entrez Gene)
MYCProtein9076 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NOTCH1Protein4851 (Entrez Gene)
NUMBRna8650 (Entrez Gene)
OCT3/4Protein9076 (Entrez Gene)
PAK4Protein10298 (Entrez Gene)
PARP1Protein9076 (Entrez Gene)
PDPK1Protein4070 (Entrez Gene)
PECAM1Protein5175 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PRKAA2Protein4851 (Entrez Gene)
PRKCAProtein5578 (Entrez Gene)
PRKCDProtein5580 (Entrez Gene)
PSAProtein9076 (Entrez Gene)
PSEN1 Protein5663 (Entrez Gene)
PSEN2Protein5664 (Entrez Gene)
PSMAProtein9076 (Entrez Gene)
PTENProtein5728 (Entrez Gene)
PTK2Protein5747 (Entrez Gene)
RAC1Protein5879 (Entrez Gene)
RACK1Protein10399 (Entrez Gene)
RB1Protein5925 (Entrez Gene)
SOX2Protein9076 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein9076 (Entrez Gene)
SYPProtein9076 (Entrez Gene)
TACSTD2Protein4070 (Entrez Gene)
TLN1Protein7094 (Entrez Gene)
TP63Protein9076 (Entrez Gene)
VIMProtein7431 (Entrez Gene)

Annotated Interactions

No annotated interactions

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