Female steroid hormones in cardiomyocyte energy metabolism (Homo sapiens)

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Adrenal GlandSarcoplasmic reticulumTriglyceride Formation andStorage in Lipid DropletsApob-lipoproteinATP ProductionLKB1TamoxifenIncreased risk of carcinogenesisOXPHOSFatty Acid UptakeCortisolPI3KFructose 1, 6-biphosphateFatty Acid SynthesisTCA CycleATP ExportCyclic GMPPKB914859888101787ERaTroponinGlucocoticoid receptorCortisol17OH-progesterone21-hydrolase11B-HSD1MitochondrionNucleusAMPK6K+CoAMTP5cTNLPGC-1α2FoxO1KATP channelGLUT4ppara8HADHBRyR2GATA4PI3K/AktEstrogen response elementeNOS4MYH6Inhibition of TNF-aCa2+MAPK6TFcAMPPPARα8MCAD8Inhibition of IL-6ATP citrate synthase 8HADHB5GLUT4ROSNOS34AMPK-stimulated GLUT-44RAF/KSR family kinases6acadm8EstrogenERRa3ERRaERbPeroxisomeERK1/2Elk-1MEF2ProgesteronePGRCardiomyocyteSuperoxide radicalSOD2Hydrogen peroxideH20O2Catalase11-deoxycortisolInhibition of IL1-BGLUT1Glucocoticoid response elementsEstrogen2ERaEstrogenEstrogenGLUT47ERaERab-oxidation of long-chain fatty acids8


Description

This pathway depicts the effect of estrogen and progesterone on energy metabolism in cardiomyocytes.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Montaigne D, Butruille L, Staels B; ''PPAR control of metabolism and cardiovascular functions.''; Nat Rev Cardiol, 2021 PubMed Europe PMC Scholia
  2. Hsieh YC, Yang S, Choudhry MA, Yu HP, Rue LW 3rd, Bland KI, Chaudry IH; ''PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide onheart function after trauma-hemorrhage.''; Am J Physiol Heart Circ Physiol, 2005 PubMed Europe PMC Scholia
  3. Wang T, McDonald C, Petrenko NB, Leblanc M, Giguere V, Evans RM, Patel VV, Pei L; ''Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function.''; Mol Cell Biol, 2015 PubMed Europe PMC Scholia
  4. Shao D, Tian R; ''Glucose Transporters in Cardiac Metabolism and Hypertrophy.''; Compr Physiol, 2015 PubMed Europe PMC Scholia
  5. Lee S, Bao H, Ishikawa Z, Wang W, Lim HY; ''Cardiomyocyte Regulation of Systemic Lipid Metabolism by the Apolipoprotein B-Containing Lipoproteins in Drosophila.''; PLoS Genet, 2017 PubMed Europe PMC Scholia
  6. Yuan J, Dong X, Yap J, Hu J; ''The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy.''; J Hematol Oncol, 2020 PubMed Europe PMC Scholia
  7. Barros RP, Machado UF, Warner M, Gustafsson JA; ''Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  8. Giguère V; ''Transcriptional control of energy homeostasis by the estrogen-related receptors.''; Endocr Rev, 2008 PubMed Europe PMC Scholia
  9. Daval M, Foufelle F, Ferré P; ''Functions of AMP-activated protein kinase in adipose tissue.''; J Physiol, 2006 PubMed Europe PMC Scholia
  10. Zhou Z, Zhou J, Du Y; ''Estrogen receptor alpha interacts with mitochondrial protein HADHB and affects beta-oxidation activity.''; Mol Cell Proteomics, 2012 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134651view09:12, 24 July 2024EgonwAdded more data node types
134650view09:08, 24 July 2024EgonwAdded a missing node type
134538view17:59, 22 July 2024EgonwAdded the Ensembl SOD2 id and the ChEBI id for superoxide radical
134473view00:48, 22 July 2024EweitzModified description
134472view00:48, 22 July 2024EweitzOntology Term : 'cardiac muscle cell' added !
125826view19:02, 12 March 2023EgonwMade a data node with a ChEBI identifier a Metabolite (was Complex)
125620view19:45, 5 March 2023AlexanderPicoModified description
125582view07:36, 1 March 2023EgonwNot a mim-conversion
125578view05:34, 1 March 2023EgonwAdded missing @Type and typo fix in gene identifier
125551view21:40, 26 February 2023AndraOntology Term : 'classic metabolic pathway' added !
125534view06:22, 26 February 2023EgonwUpdated the Ensembl data source
125532view06:20, 26 February 2023EgonwMarked a data node with an Ensembl identifier as "GeneProduct"
125531view06:18, 26 February 2023EgonwMarked a data node with a ChEBI identifier as "Metabolite"
125529view17:57, 25 February 2023EgonwUpdated the UniProt data sources
125527view17:53, 25 February 2023EgonwMade a few pathways clickable
125263view12:28, 31 January 2023LianatyrrelleNOS pathway added
125252view19:07, 30 January 2023LianatyrrellAdded Element Type
125251view17:44, 30 January 2023Mehaa
125243view16:18, 30 January 2023Natalie.vlinked keywords to existing pathways
125231view14:35, 30 January 2023LianatyrrellReferences
125230view14:11, 30 January 2023LianatyrrellAltered ERa pathways
125181view11:46, 27 January 2023Natalie.v
125180view11:43, 27 January 2023Natalie.vadded all identifiers and references for ERRa pathwa
125179view11:33, 27 January 2023Natalie.vadded some references
125174view14:11, 26 January 2023Mehaa
125172view14:06, 26 January 2023Mehaa
125170view13:18, 26 January 2023Natalie.vadded parts to ERRa and made the map cleaner
125169view13:00, 26 January 2023Natalie.v
125161view15:06, 25 January 2023Natalie.vtest
125159view14:43, 25 January 2023Natalie.vModified title
125152view13:35, 25 January 2023Mehaa
125147view13:05, 25 January 2023Mehaa
125146view12:51, 25 January 2023Mehaa
125145view11:43, 25 January 2023Mehaa
125144view11:40, 25 January 2023Mehaa
125143view11:39, 25 January 2023Mehaa
125142view11:37, 25 January 2023Mehaa
125139view21:36, 24 January 2023Mehaa
125138view21:29, 24 January 2023Mehaa
125137view21:25, 24 January 2023Mehaa
125136view20:05, 24 January 2023MehaaTitle changed
125135view20:03, 24 January 2023MehaaNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11-deoxycortisolMetaboliteR-HSA-194002 (Reactome)
11B-HSD1R-HSA-194002 (Reactome)
17OH-progesteroneMetaboliteR-HSA-194002 (Reactome)
21-hydrolaseProteinR-HSA-194002 (Reactome)
AMPK-stimulated GLUT-4Protein
AMPKPathway2.7.11.31 (Enzyme Nomenclature)
ATP ExportPathwayWP1902 (WikiPathways)
ATP ProductionPathwayWP1902 (WikiPathways)
ATP citrate synthase ProteinP53396 (Uniprot-TrEMBL)
Apob-lipoproteinProteinENSG00000084674 (Ensembl)
Ca2+Metabolite9606 (NCI Pathway Interaction Database)
CatalasePathwayP04040 (Pathway Commons)
CoAProteinCoenzyme A
CortisolR-HSA-194002 (Reactome)
Cyclic GMPMetabolite16356 (ChEBI)
ERK1/2PathwayWP382 (WikiPathways)
ERRaProteinP11474 (Uniprot-TrEMBL)
ERaProteinP03372 (Uniprot-TrEMBL)
ERbProteinP11474 (Uniprot-TrEMBL)
Elk-1GeneProductUP000005640 (Uniprot-TrEMBL)
Estrogen response elementGeneProduct
EstrogenMetaboliteCHEBI:50114 (ChEBI)
Fatty Acid SynthesisPathwayWP357 (WikiPathways)
Fatty Acid UptakePathwayWP357 (WikiPathways)
FoxO1GeneProductUP000005640 (Uniprot-TrEMBL)
Fructose 1, 6-biphosphateProtein
GATA4GeneProductENSG00000181856 (Ensembl)
GLUT1GeneProductENSG00000181856 (Ensembl)
GLUT4GeneProduct
GLUT4GeneProductENSG00000181856 (Ensembl)
Glucocoticoid receptorP04150 (Pathway Commons)
Glucocoticoid response elements P04150 (Pathway Commons)
H20Metabolite
HADHBGeneProductENSG00000138029 (Ensembl)
Hydrogen peroxideMetabolite
Increased risk of carcinogenesis
Inhibition of IL-6PathwayP05231 (Pathway Commons)
Inhibition of IL1-BP01584 (Pathway Commons)
Inhibition of TNF-aGeneProductUP000005640 (Uniprot-TrEMBL)
K+Metabolite
KATP channelPathwayQ15842 (Pathway Commons)
LKB1ProteinENSG00000118046 (Ensembl)
MAPKPathwayENSG00000100030 (Ensembl)
MCADProteinP11310 (Uniprot-TrEMBL)
MEF2GeneProductUP0000005640 (Uniprot-TrEMBL)
MTPGeneProductENSG00000138823 (Ensembl)
MYH6GeneProductUP000005640 (Uniprot-TrEMBL)
NOS3ProteinENSG00000164867 (Ensembl)
O2Metabolite
OXPHOSPathwayWP623 (WikiPathways)
PGC-1αProteinQ86YN6 (Uniprot-TrEMBL)
PGRProteinP11474 (Uniprot-TrEMBL)
PI3KProtein
PI3K/AktPathwayWP4448 (WikiPathways)
PKBProteinENSG00000105221 (Ensembl)
PPARαProteinQ07869 (Uniprot-TrEMBL)
ProgesteroneProteinP11474 (Uniprot-TrEMBL)
RAF/KSR family kinasesProtein
ROSGeneProductUP000002494 (Uniprot-TrEMBL)
RyR2ProteinENST000006099119.1 (Ensembl)
SOD2GeneProductENSG00000291237 (Ensembl)
Superoxide radicalMetabolite18421 (ChEBI)
TCA CyclePathwayWP78 (WikiPathways)
TFProteinTranscription Factors
TamoxifenMetabolite41774 (ChEBI)
Triglyceride Formation and Storage in Lipid DropletsPathwayWP4131 (WikiPathways)
TroponinProteinUP000005640 (Uniprot-TrEMBL)
acadm GeneProductENSG00000117054 (Ensembl)
b-oxidation of long-chain fatty acidsPathwayWP5123 (WikiPathways)
cAMPMetabolite17489 (ChEBI)
cTNLGeneProducthsa:1514 (KEGG Genes)
eNOSProteinENSG00000164867 (Ensembl)
pparaGeneProductENSG00000186951 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5318"
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