Induction of autophagy and toll-like receptor signaling by graphene oxide (Homo sapiens)
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Description
Graphene oxide has been found in the RAW264.7 to trigger a cytokine response and resulting autophagy. It was found to be mediated by activation of TLR4 and TLR9, signalling MyD88, TRAF6, and NF-κB, resulting in cytokine expression. However, TLR signaling did not cause IFN-β expression nor IRF3 activation. The process also shows activation of Beclin 1 and LC3.
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Ontology Terms
Saving...Bibliography
- Chen GY, Yang HJ, Lu CH, Chao YC, Hwang SM, Chen CL, Lo KW, Sung LY, Luo WY, Tuan HY, Hu YC; ''Simultaneous induction of autophagy and toll-like receptor signaling pathways by graphene oxide.''; Biomaterials, 2012 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| Beclin1 | GeneProduct | Q14457 (Uniprot-TrEMBL)  | |
| GO | Metabolite | Q95981922 (Wikidata) | graphene oxide |
| IFN-beta | GeneProduct | P01574 (Uniprot-TrEMBL) | |
| IFN-gamma | GeneProduct | P01579 (Uniprot-TrEMBL) | |
| IRF3 | GeneProduct | ENSG00000126456 (Ensembl) | |
| LC3 | GeneProduct | Q9H492 (Uniprot-TrEMBL) | Guess based on Wikipedia, which mentions this LC3 in the context of autophagy. |
| MYD88 | GeneProduct | ENSG00000172936 (Ensembl) | |
| NF-kappaB | GeneProduct | P19838 (Uniprot-TrEMBL) | ID annotation derived from the label. |
| TLR4 | GeneProduct | ENSG00000136869 (Ensembl) | |
| TLR9 | GeneProduct | ENSG00000239732 (Ensembl) | |
| TNF-alpha | GeneProduct | P01375 (Uniprot-TrEMBL) | |
| TRAF6 | GeneProduct | ENSG00000175104 (Ensembl) | |
| TRIF | GeneProduct | ||
| autophagy | Pathway | WP4923 (WikiPathways) |
Annotated Interactions
No annotated interactions
