Induction of autophagy and toll-like receptor signaling pathways by graphene oxide (Homo sapiens)

From WikiPathways

Jump to: navigation, search


Graphene oxide has been found in the RAW264.7 to trigger a cytokine response and resulting autophagy. It was found to be mediated by activation of TLR4 and TLR9, signalling MyD88, TRAF6, and NF-κB, resulting in cytokine expression. However, TLR signaling did not cause IFN-β expression nor IRF3 activation. The process also shows activation of Beclin 1 and LC3.

Try the New WikiPathways

View approved pathways at the new

Quality Tags

Ontology Terms



  1. Chen GY, Yang HJ, Lu CH, Chao YC, Hwang SM, Chen CL, Lo KW, Sung LY, Luo WY, Tuan HY, Hu YC; ''Simultaneous induction of autophagy and toll-like receptor signaling pathways by graphene oxide.''; Biomaterials, 2012 PubMed Europe PMC Scholia


View all...
126593view08:29, 6 June 2023EgonwMore identifiers
126592view08:04, 6 June 2023EgonwAdded more identifiers
125993view15:22, 24 March 2023EgonwOntology Term : 'classic metabolic pathway' added !
125992view15:22, 24 March 2023EgonwOntology Term : 'cytokine mediated signaling pathway' added !
125679view21:29, 6 March 2023EgonwAdded a number of identifiers
125667view16:18, 6 March 2023EgonwAdded the reference
125663view16:11, 6 March 2023EgonwAdded interactions
125657view16:01, 6 March 2023EgonwModified description
125653view15:53, 6 March 2023EgonwNew pathway

External references


View all...
NameTypeDatabase referenceComment
Beclin1GeneProductQ14457 (Uniprot-TrEMBL)
GOMetaboliteQ95981922 (Wikidata) graphene oxide
IFN-betaGeneProductP01574 (Uniprot-TrEMBL)
IFN-gammaGeneProductP01579 (Uniprot-TrEMBL)
IRF3GeneProductENSG00000126456 (Ensembl)
LC3GeneProductQ9H492 (Uniprot-TrEMBL) Guess based on Wikipedia, which mentions this LC3 in the context of autophagy.
MYD88GeneProductENSG00000172936 (Ensembl)
NF-kappaBGeneProductP19838 (Uniprot-TrEMBL) ID annotation derived from the label.
TLR4GeneProductENSG00000136869 (Ensembl)
TLR9GeneProductENSG00000239732 (Ensembl)
TNF-alphaGeneProductP01375 (Uniprot-TrEMBL)
TRAF6GeneProductENSG00000175104 (Ensembl)
autophagyPathwayWP4923 (WikiPathways)

Annotated Interactions

No annotated interactions

Personal tools