UDP-derived sugars synthesis in fibroblasts (Homo sapiens)

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1-11HK3UGDHGALEPGM1HK1PGM3GPIUDP-α-D-galactoseGALEUXS1UDP-α-D-glucoseGCKHK2GFPT1β-D-fructofuranose 6-phosphateN-acetyl-α-D-galactosamine 1-phosphateα-D-galactosamine 1-phosphateD-galactosamine 6-phosphateD-glucosamine 6-phosphateUDP-N-acetyl-α-D-galactosamineUDP-N-acetyl-α-D-glucosamineN-acetyl-α-D-glucosamine 1-phosphateN-acetyl-α-D-glucosamine 6-phosphateα-D-glucosamine 1-phosphateα-D-glucose 6-phosphateD-glucopyranose 6-phosphateD-glucopyranoseUDP-α-D-xyloseUDP-α-D-glucuronate


Description

One of the main roles of fibroblasts is the secretion of the extracellular matrix components such as glycosaminoglycans (GAGs). This pathway describes the synthesis of GAGs precursors - five UDP-derived sugars (UDP-α-D-galactose, UDP-α-D-glucuronate, UDP-α-D-xylose, UDP-N-acetyl-α-D-galactosamine, UDP-N-α-alpha-D-glucosamine). It takes place in the cytosol, where it starts with the conversion of D-glucopyranose to D-glucopyranose 6-phosphate, after which it can either proceed via a shorter or a longer path. The shorter leads to the synthesis of UDP-α-D-galactose, UDP-α-D-glucuronate and UDP-α-D-xylose, while the longer leads to the synthesis of UDP-N-acetyl-α-D-galactosamine and UDP-N-acetyl-α-D-glucosamine. Some of the enzymes are missing in the pathway and can be a subject for future research.

This pathway was created based on the pathway information from the MetaCyc database (see Bibliography).

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Ontology Terms

 

Bibliography

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  1. Caspi R, Billington R, Keseler IM, Kothari A, Krummenacker M, Midford PE, Ong WK, Paley S, Subhraveti P, Karp PD; ''The MetaCyc database of metabolic pathways and enzymes - a 2019 update.''; Nucleic Acids Res, 2020 PubMed Europe PMC Scholia
  2. Huang YF, Mizumoto S, Fujita M; ''Novel Insight Into Glycosaminoglycan Biosynthesis Based on Gene Expression Profiles.''; Front Cell Dev Biol, 2021 PubMed Europe PMC Scholia
  3. Casale J, Crane JS; ''Biochemistry, Glycosaminoglycans''; https://www.ncbi.nlm.nih.gov/books/NBK544295/#:~:text=The%20process%20of%20GAG%20biosynthesis,and%20UDP%2DN%2Dacetylgalactosamine., 2023
  4. Caspi R; ''Pathway: UDP-α-D-glucuronate biosynthesis (from UDP-glucose)''; https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7346, 2013
  5. Keseler I; ''Pathway: UDP-N-acetyl-D-glucosamine biosynthesis I''; https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=UDPNAGSYN-PWY, 2007
  6. Fulcher CA, Ying HC; ''Pathway: UDP-N-acetyl-D-glucosamine biosynthesis II''; https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=UDPNACETYLGALSYN-PWY, 2007
  7. Tissier C; ''Pathway: UDP-α-D-xylose biosynthesis''; https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-4821&ENZORG=NIL, 2005
  8. Caspi R; ''Pathway: UDP-α-D-galactose biosynthesis''; https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-7344&ENZORG=TAX-9606, 2013
  9. Fulcher CA; ''Pathway: UDP-N-acetyl-D-galactosamine biosynthesis I''; https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5512&ENZORG=TAX-9606, 2007
  10. Caspi R, Fulcher CA; ''Pathway: UDP-N-acetyl-D-galactosamine biosynthesis II''; https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5514, 2007
  11. Caspi R; ''Pathway: UDP-N-acetyl-D-galactosamine biosynthesis III''; https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-8013, 2018

History

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CompareRevisionActionTimeUserComment
126941view12:31, 7 July 2023DdiglesOntology Term : 'nucleotide sugar metabolic pathway' added !
126914view21:16, 2 July 2023JuliabladModified description
126913view21:14, 2 July 2023JuliabladModified description
126909view18:36, 2 July 2023JuliabladOntology Term : 'classic metabolic pathway' added !
126908view18:36, 2 July 2023JuliabladOntology Term : 'fibroblast' added !
126907view18:32, 2 July 2023JuliabladNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
D-galactosamine 6-phosphateMetabolite71674 (ChEBI)
D-glucopyranose 6-phosphateMetabolite4170 (ChEBI)
D-glucopyranoseMetabolite4167 (ChEBI)
D-glucosamine 6-phosphateMetabolite58725 (ChEBI)
GALEGeneProductENSG00000117308 (Ensembl)
GCKGeneProductENSG00000106633 (Ensembl)
GFPT1GeneProductENSG00000198380 (Ensembl)
GPIGeneProductENSG00000105220 (Ensembl)
HK1GeneProductENSG00000156515 (Ensembl)
HK2GeneProductENSG00000159399 (Ensembl)
HK3GeneProductENSG00000160883 (Ensembl)
N-acetyl-α-D-galactosamine 1-phosphateMetabolite61970 (ChEBI)
N-acetyl-α-D-glucosamine 1-phosphateMetabolite57776 (ChEBI)
N-acetyl-α-D-glucosamine 6-phosphateMetabolite57513 (ChEBI)
PGM1GeneProductENSG00000079739 (Ensembl)
PGM3GeneProductENSG00000013375 (Ensembl)
UDP-N-acetyl-α-D-galactosamineMetabolite67138 (ChEBI)
UDP-N-acetyl-α-D-glucosamineMetabolite57705 (ChEBI)
UDP-α-D-galactoseMetabolite66914 (ChEBI)
UDP-α-D-glucoseMetabolite58885 (ChEBI)
UDP-α-D-glucuronateMetabolite58052 (ChEBI)
UDP-α-D-xyloseMetabolite57632 (ChEBI)
UGDHGeneProductENSG00000109814 (Ensembl)
UXS1GeneProductENSG00000115652 (Ensembl)
α-D-galactosamine 1-phosphateMetabolite142399 (ChEBI)
α-D-glucosamine 1-phosphateMetabolite58516 (ChEBI)
α-D-glucose 6-phosphateMetabolite58225 (ChEBI)
β-D-fructofuranose 6-phosphateMetabolite57634 (ChEBI)

Annotated Interactions

No annotated interactions

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