De novo NAD biosynthesis (Saccharomyces cerevisiae)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none spontaneousnicotinate nucleotideL-FormylkynurenineBNA6BNA5L-alanineBNA3H2OBNA12-Amino-3-carboxymuconate semialdehyde3-hydroxyanthranilatepyrophosphateformateATPPRPPBNA4kynureninequinolinateQNS1NADBNA2O2L-tryptophandeamido-NAD3-hydroxy-L-kynurenineCO2pyrophosphateNADPH2ONMA2NMA1NADPHO2AMPL-glutamatepyrophosphateATPL-glutamineH2OH2OH2OO2Name: De novo NAD biosynthesisOrganism: Saccharomyces cerevisiae


Description

Most organisms synthesize NAD+ from simple components. The specific set of reactions differs among organisms, but a common feature is the generation of quinolinic acid (QA) from an amino acid – either tryptophan (Trp) in animals and some bacteria, or aspartic acid (Asp) in some bacteria and plants. The quinolinic acid is converted to nicotinic acid mononucleotide (NaMN) by transfer of a phosphoribose moiety. An adenylate moiety is then transferred to form nicotinic acid adenine dinucleotide (NaAD). Finally, the nicotinic acid moiety in NaAD is amidated to a nicotinamide (Nam) moiety, forming nicotinamide adenine dinucleotide. Description adapted from [Wikipedia](https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide).

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Pathway Ontology : chorismate metabolic pathway
 

Bibliography

  1. ''NAD de novo biosynthesis II (from tryptophan)''; YeastPathways,

History

View all...
CompareRevisionActionTimeUserComment
137464
Approved
view14:54, 2 March 2025EgonwModified description
135943view05:00, 3 December 2024Khanspersupdated to mim-conversion, economize layout
135457view22:24, 5 September 2024KhanspersModified description
135456view22:21, 5 September 2024Khansperslit ref
135455view22:20, 5 September 2024Khanspersadded lit ref
135305view23:46, 15 August 2024KhanspersOntology Term : 'classic metabolic pathway' added !
135304view23:45, 15 August 2024Khanspersfix interactions, add metabolite ids, layout
117291view11:03, 20 May 2021EweitzModified title
92995view18:21, 21 July 2017KhanspersModified description
92994view18:21, 21 July 2017Khanspersremoved GenMAPP notes
92894view19:08, 14 July 2017EgonwReplace a CAS number for a totally different compound with the ChEBI ID for L-alanine.
89707view06:57, 27 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
69942view20:17, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69623view20:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
67145view10:12, 26 June 2013Christine ChichesterOntology Term : 'de novo nicotinamide adenine dinucleotide biosynthetic pathway' added !
41858view04:51, 2 March 2011MaintBotRemoved redundant pathway information and comments
21818view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:De Novo NAD Biosynthesis]] moved to [[Pathway:WP541]]: Moved to stable identifier
12688view07:58, 17 May 2008MaintBotautomated metabolite conversion
8693view14:06, 7 January 2008MaintBotAdded to category $category
8691view14:06, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
2-Amino-3-carboxymuconate semialdehydeMetaboliteCHEBI:995 (ChEBI)
3-hydroxy-L-kynurenineMetabolite606-14-4 (CAS)
3-hydroxyanthranilateMetaboliteCHEBI:36559 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
ATPMetabolite1927-31-7 (CAS)
BNA1GeneProductS000003786 (SGD)
BNA2GeneProductS000003839 (SGD)
BNA3GeneProductS000003596 (SGD)
BNA4GeneProductS000000194 (SGD)
BNA5GeneProductS000004221 (SGD)
BNA6GeneProductS000001943 (SGD)
CO2MetaboliteCHEBI:16526 (ChEBI)
H2OMetaboliteHMDB02111 (HMDB)
L-FormylkynurenineMetabolite1022-31-7 (CAS)
L-alanineMetaboliteCHEBI:16977 (ChEBI)
L-glutamateMetabolite56-86-0 (CAS)
L-glutamineMetabolite56-85-9 (CAS)
L-tryptophanMetabolite73-22-3 (CAS)
NADMetaboliteCHEBI:16908 (ChEBI)
NADPMetaboliteCHEBI:44409 (ChEBI)
NADPHMetabolite53-57-6 (CAS)
NMA1GeneProductS000004320 (SGD)
NMA2GeneProductS000003242 (SGD)
O2MetaboliteCHEBI:25805 (ChEBI)
PRPPMetabolite97-55-2 (CAS)
QNS1GeneProductS000001116 (SGD)
deamido-NADMetaboliteQ28529688 (Wikidata)
formateMetaboliteCHEBI:15740 (ChEBI)
kynurenineMetabolite343-65-7 (CAS)
pyrophosphateMetabolite2466-09-3 (CAS)
quinolinateMetaboliteCHEBI:29959 (ChEBI)

Annotated Interactions

No annotated interactions

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