Cell lineage map for neuronal differentiation (Homo sapiens)

From WikiPathways

Jump to: navigation, search


Description

This cell lineage map consists of a set of cell types emerging during neural differentiation.

A selection of cell type-specific markers was made based on literature (e.g. Beccari et al., 2018, https://doi.org/10.1038/s41586-018-0578-0; Kügler et al., 2010, https://doi.org/10.14573/altex.2010.1.16; Spangler et al., 2018, https://doi.org/10.1016/j.scr.2018.07.022; Tao and Zhang, 2016, https://doi.org/10.1016/j.stem.2016.10.015) to distinguish these different cell types. This map was published in: Victoria de Leeuw et al., 2020, NeuroToxicology 76, 1-9. https://doi.org/10.1016/j.neuro.2019.09.014.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. ''Markers of murine embryonic and neural stem cells, neurons and astrocytes: Reference points for developmental neurotoxicity testing ''; , DOI Scholia
  2. ''Neural Subtype Specification from Human Pluripotent Stem Cells''; , DOI Scholia
  3. ''Differential effects of fluoxetine and venlafaxine in the neural embryonic stem cell test (ESTn) revealed by a cell lineage map''; , DOI Scholia
  4. ''A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo''; , DOI Scholia
  5. ''Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids''; , DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
139855view11:37, 8 July 2025DdiglesDeleted hidden old description
128450view18:13, 4 February 2024EweitzOntology Term : 'serotonergic neuron' added !
128449view18:13, 4 February 2024EweitzOntology Term : 'cholinergic neuron' added !
128448view18:13, 4 February 2024EweitzOntology Term : 'GABAergic neuron' added !
128447view18:12, 4 February 2024EweitzOntology Term : 'noradrenergic neuron' added !
128446view18:12, 4 February 2024EweitzOntology Term : 'dopaminergic neuron' added !
128445view18:11, 4 February 2024EweitzOntology Term : 'glutamatergic neuron' added !
128444view18:11, 4 February 2024EweitzOntology Term : 'oligodendrocyte' added !
128443view18:10, 4 February 2024EweitzOntology Term : 'astrocyte' added !
128442view18:10, 4 February 2024EweitzOntology Term : 'neural crest cell' added !
128441view18:10, 4 February 2024EweitzOntology Term : 'neural progenitor cell' added !
128440view18:09, 4 February 2024EweitzOntology Term : 'endodermal cell' added !
128439view18:09, 4 February 2024EweitzOntology Term : 'mesodermal cell' added !
128438view18:09, 4 February 2024EweitzOntology Term : 'ectodermal cell' added !
128437view18:09, 4 February 2024EweitzOntology Term : 'stem cell' added !
128436view18:08, 4 February 2024EweitzStandardize case
127426view10:10, 1 October 2023EgonwAdded the titles of the DOI articles
127425view10:07, 1 October 2023EgonwAdded the DOIs as literature references (to be completed on classic)
127420view09:53, 1 October 2023EgonwOntology Term : 'regulatory pathway' added !
127419view09:53, 1 October 2023EgonwOntology Term : 'neuron' added !
127321view08:52, 14 September 2023PenningsModified description
127318view08:47, 14 September 2023PenningsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACHEGeneProductENSG00000087085 (Ensembl)
ADRA2AGeneProductENSG00000150594 (Ensembl)
ADRA2BGeneProductENSG00000274286 (Ensembl)
ADRA2CGeneProductENSG00000184160 (Ensembl)
ALDH1L1GeneProductENSG00000144908 (Ensembl)
AP2A1GeneProductENSG00000196961 (Ensembl)
AP2A2GeneProductENSG00000183020 (Ensembl)
AQP4GeneProductENSG00000171885 (Ensembl)
BMP4GeneProductENSG00000125378 (Ensembl)
BSNGeneProductENSG00000164061 (Ensembl)
CACNG2GeneProductENSG00000166862 (Ensembl)
CASKGeneProductENSG00000147044 (Ensembl)
CD24GeneProductENSG00000272398 (Ensembl)
CD34GeneProductENSG00000174059 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDH2GeneProductENSG00000170558 (Ensembl)
CHATGeneProductENSG00000070748 (Ensembl)
CLDN11GeneProductENSG00000013297 (Ensembl)
CNPGeneProductENSG00000173786 (Ensembl)
CSPG4GeneProductENSG00000173546 (Ensembl)
DCXGeneProductENSG00000077279 (Ensembl)
DLG1GeneProductENSG00000075711 (Ensembl)
DLG2GeneProductENSG00000150672 (Ensembl)
DLG3GeneProductENSG00000082458 (Ensembl)
DLG4GeneProductENSG00000132535 (Ensembl)
DLL1GeneProductENSG00000198719 (Ensembl)
DPPA2GeneProductENSG00000163530 (Ensembl)
DPPA3GeneProductENSG00000187569 (Ensembl)
ERASGeneProductENSG00000187682 (Ensembl)
ERC1GeneProductENSG00000082805 (Ensembl)
ESRRBGeneProductENSG00000119715 (Ensembl)
EVX1GeneProductENSG00000106038 (Ensembl)
FABP7GeneProductENSG00000164434 (Ensembl)
FBXO15GeneProductENSG00000141665 (Ensembl)
FEVGeneProductENSG00000163497 (Ensembl)
FGF4GeneProductENSG00000075388 (Ensembl)
FOXA2GeneProductENSG00000125798 (Ensembl)
FOXD3GeneProductENSG00000187140 (Ensembl)
FUT4GeneProductENSG00000196371 (Ensembl)
GABBR1GeneProductENSG00000204681 (Ensembl)
GABBR2GeneProductENSG00000136928 (Ensembl)
GAD1GeneProductENSG00000128683 (Ensembl)
GAD2GeneProductENSG00000136750 (Ensembl)
GATA4GeneProductENSG00000136574 (Ensembl)
GATA6GeneProductENSG00000141448 (Ensembl)
GFAPGeneProductENSG00000131095 (Ensembl)
GLRA1GeneProductENSG00000145888 (Ensembl)
GLRA2GeneProductENSG00000101958 (Ensembl)
GLRA3GeneProductENSG00000145451 (Ensembl)
GLRA4GeneProductENSG00000188828 (Ensembl)
GLRBGeneProductENSG00000109738 (Ensembl)
GLSGeneProductENSG00000115419 (Ensembl)
GLULGeneProductENSG00000135821 (Ensembl)
GPHNGeneProductENSG00000171723 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
HES1GeneProductENSG00000114315 (Ensembl)
HES3GeneProductENSG00000173673 (Ensembl)
HES5GeneProductENSG00000197921 (Ensembl)
HNF4AGeneProductENSG00000101076 (Ensembl)
HOMER1GeneProductENSG00000152413 (Ensembl)
HOMER2GeneProductENSG00000103942 (Ensembl)
HOMER3GeneProductENSG00000051128 (Ensembl)
HTR1AGeneProductENSG00000178394 (Ensembl)
HTR5AGeneProductENSG00000157219 (Ensembl)
ITGA6GeneProductENSG00000091409 (Ensembl)
ITGB1GeneProductENSG00000150093 (Ensembl)
KCNJ6GeneProductENSG00000157542 (Ensembl)
KLF4GeneProductENSG00000136826 (Ensembl)
KRT15GeneProductENSG00000171346 (Ensembl)
LEF1GeneProductENSG00000138795 (Ensembl)
LHX1GeneProductENSG00000273706 (Ensembl)
LIN7AGeneProductENSG00000111052 (Ensembl)
LMX1BGeneProductENSG00000136944 (Ensembl)
MAP2GeneProductENSG00000078018 (Ensembl)
MBPGeneProductENSG00000197971 (Ensembl)
MIXL1GeneProductENSG00000185155 (Ensembl)
MOGGeneProductENSG00000204655 (Ensembl)
MSX1GeneProductENSG00000163132 (Ensembl)
MSX2GeneProductENSG00000120149 (Ensembl)
NANOGGeneProductENSG00000111704 (Ensembl)
NEFLGeneProductENSG00000277586 (Ensembl)
NEFMGeneProductENSG00000104722 (Ensembl)
NESGeneProductENSG00000132688 (Ensembl)
NGFRGeneProductENSG00000064300 (Ensembl)
NLGN1GeneProductENSG00000169760 (Ensembl)
NODALGeneProductENSG00000156574 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
NR4A2GeneProductENSG00000153234 (Ensembl)
OLIG2GeneProductENSG00000205927 (Ensembl)
PAX3GeneProductENSG00000135903 (Ensembl)
PAX6GeneProductENSG00000007372 (Ensembl)
PCLOGeneProductENSG00000186472 (Ensembl)
PECAM1GeneProductENSG00000261371 (Ensembl)
POU5F1GeneProductENSG00000204531 (Ensembl)
PPFIA1GeneProductENSG00000131626 (Ensembl)
RBFOX3GeneProductENSG00000167281 (Ensembl)
RIMBP2GeneProductENSG00000060709 (Ensembl)
RIMS2GeneProductENSG00000176406 (Ensembl)
ROBO1GeneProductENSG00000169855 (Ensembl)
S100BGeneProductENSG00000160307 (Ensembl)
SHANK1GeneProductENSG00000161681 (Ensembl)
SHANK3GeneProductENSG00000251322 (Ensembl)
SLC17A6GeneProductENSG00000091664 (Ensembl)
SLC17A7GeneProductENSG00000104888 (Ensembl)
SLC18A3GeneProductENSG00000187714 (Ensembl)
SLC1A2GeneProductENSG00000110436 (Ensembl)
SLC1A3GeneProductENSG00000079215 (Ensembl)
SLC6A1GeneProductENSG00000157103 (Ensembl)
SLC6A2GeneProductENSG00000103546 (Ensembl)
SLC6A3GeneProductENSG00000142319 (Ensembl)
SLC6A4GeneProductENSG00000108576 (Ensembl)
SLC6A5GeneProductENSG00000165970 (Ensembl)
SLC6A9GeneProductENSG00000196517 (Ensembl)
SNAI1GeneProductENSG00000124216 (Ensembl)
SNAI2GeneProductENSG00000019549 (Ensembl)
SNAP25GeneProductENSG00000132639 (Ensembl)
SOX10GeneProductENSG00000100146 (Ensembl)
SOX17GeneProductENSG00000164736 (Ensembl)
SOX2GeneProductENSG00000181449 (Ensembl)
SOX9GeneProductENSG00000125398 (Ensembl)
SYPGeneProductENSG00000102003 (Ensembl)
TBR1GeneProductENSG00000136535 (Ensembl)
TBXTGeneProductENSG00000164458 (Ensembl)
THGeneProductENSG00000180176 (Ensembl)
TNCGeneProductENSG00000041982 (Ensembl)
TPH1GeneProductENSG00000129167 (Ensembl)
TPM1GeneProductENSG00000140416 (Ensembl)
TUBB3GeneProductENSG00000258947 (Ensembl)
TWIST1GeneProductENSG00000122691 (Ensembl)
TWIST2GeneProductENSG00000233608 (Ensembl)
UNC13AGeneProductENSG00000130477 (Ensembl)
ZFP42GeneProductENSG00000179059 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5417"
Personal tools