IL19 signaling (Homo sapiens)

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Description

Schematic representation of IL-19 signaling pathway

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, Walker LA; ''Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner.''; World J Cardiol, 2017 PubMed Europe PMC Scholia
  2. Jain S, Gabunia K, Kelemen SE, Panetti TS, Autieri MV; ''The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells.''; Arterioscler Thromb Vasc Biol, 2011 PubMed Europe PMC Scholia
  3. Keller KE, Yang YF, Sun YY, Walter MR, Wirtz MK; ''Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture.''; Mol Vis, 2019 PubMed Europe PMC Scholia
  4. Tian Y, Sommerville LJ, Cuneo A, Kelemen SE, Autieri MV; ''Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia.''; Am J Pathol, 2008 PubMed Europe PMC Scholia
  5. Zhong H, Wu Y, Belardinelli L, Zeng D; ''A2B adenosine receptors induce IL-19 from bronchial epithelial cells, resulting in TNF-alpha increase.''; Am J Respir Cell Mol Biol, 2006 PubMed Europe PMC Scholia
  6. Hsing CH, Kwok FA, Cheng HC, Li CF, Chang MS; ''Inhibiting interleukin-19 activity ameliorates esophageal squamous cell carcinoma progression.''; PLoS One, 2013 PubMed Europe PMC Scholia
  7. Hsu YH, Li HH, Sung JM, Chen WT, Hou YC, Chang MS; ''Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury.''; PLoS One, 2013 PubMed Europe PMC Scholia
  8. Higashino M, Takabayashi T, Takahashi N, Okamoto M, Narita N, Kojima A, Hyo S, Kawata R, Takenaka H, Fujieda S; ''Interleukin-19 downregulates interleukin-4-induced eotaxin production in human nasal fibroblasts.''; Allergol Int, 2011 PubMed Europe PMC Scholia
  9. Lai X, Li X, Chang L, Chen X, Huang Z, Bao H, Huang J, Yang L, Wu X, Wang Z, Bellanti JA, Zheng SG, Zhang G; ''IL-19 Up-Regulates Mucin 5AC Production in Patients With Chronic Rhinosinusitis via STAT3 Pathway.''; Front Immunol, 2019 PubMed Europe PMC Scholia
  10. He Y, Luo W, Liu Y, Wang Y, Ma C, Wu Q, Tian P, He D, Jia Z, Lv X, Ma YS, Yang H, Xu K, Zhang X, Xiao Y, Zhang P, Liang Y, Fu D, Yao F, Hu G; ''IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer.''; J Clin Invest, 2022 PubMed Europe PMC Scholia
  11. Xiao M, Zhang W, Liu W, Mao L, Yang J, Hu L, Zhang S, Zheng Y, Liu A, Song Q, Li Y, Xiao G, Zou Z, Bai X; ''Osteocytes regulate neutrophil development through IL-19: a potent cytokine for neutropenia treatment.''; Blood, 2021 PubMed Europe PMC Scholia
  12. Li X, Huang J, Chen X, Lai X, Huang Z, Li Y, Li S, Chang L, Zhang G; ''''; , PubMed Europe PMC Scholia
  13. Wang Y, Sun S, Wang K, Zhang M, Li M, Zan Y, Huang Q, Wu S, Zhao W, Xu W, Wu J; ''Interleukin-19 Aggravates Pulmonary Fibrosis via Activating Fibroblast through TGF-β/Smad Pathway.''; Mediators Inflamm, 2022 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
142058view22:51, 30 November 2025EweitzRemove deprecated metadata fields
129674view00:45, 22 May 2024EweitzModified title
127701view01:17, 23 November 2023EweitzOntology Term : 'Interleukin mediated signaling pathway' added !
127700view01:17, 23 November 2023EweitzOntology Term : 'interleukin-19 signaling pathway' added !
127699view01:16, 23 November 2023EweitzModified title
127461view12:45, 6 October 2023JmillanacostaChanged data nodes for graphical shapes in legend
127458view19:40, 4 October 2023Khanspersupdated legend to graphical lines
127418view09:49, 1 October 2023EgonwConverted three interactions that are not mim-conversions not a regular Arrow
127405view11:41, 30 September 2023EgonwAll WikiPathways content is CC0
127404view11:37, 30 September 2023IsabelWassinkOntology Term : 'signaling pathway' added !
127374view23:31, 24 September 2023Rex D A BModified title
127373view23:29, 24 September 2023Rex D A BNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTA2Protein59 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
Akt1Protein11651 (Entrez Gene)
CCL11 Protein6356 (Entrez Gene)
CCNB1Protein891 (Entrez Gene)
COL1A1 Protein1277 (Entrez Gene)
CXCR4Protein7852 (Entrez Gene)
Casp3 Protein12367 (Entrez Gene)
Casp9Protein12371 (Entrez Gene)
Ccl2Protein20296 (Entrez Gene)
IL10Protein16176 (Entrez Gene)
IL13 Protein29949 (Entrez Gene)
IL13RProtein53832 (Entrez Gene)
IL17 Protein29949 (Entrez Gene)
IL17RProtein53832 (Entrez Gene)
IL19 Protein29949 (Entrez Gene)
IL19Protein29949 (Entrez Gene)
IL19Protein29949 (NCBI Protein)
IL1BProtein16176 (Entrez Gene)
IL20RAProtein53832 (Entrez Gene)
IL20RBProtein53833 (Entrez Gene)
IL4 Protein3565 (Entrez Gene)
IL4RProtein3566 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
MAP2K1 Protein
MAP2K2Protein
MAPK1 Protein
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MMP1Protein4312 (Entrez Gene)
MMP9Protein
MUC5ACProtein4586 (Entrez Gene)
Mapk1Protein26413 (Entrez Gene)
Mapk14Protein26416 (Entrez Gene)
Mapk3Protein26417 (Entrez Gene)
Mapk8Protein26419 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein
Protein0 (Entrez Gene)
RAC1 Protein5879 (Entrez Gene)
RELA Protein
SMAD3 Protein20848 (Entrez Gene)
SOCS1 GeneProduct8651 (Entrez Gene)
SOCS5Protein9655 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3 Protein6774 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT6Protein6778 (Entrez Gene)
Stat3Protein20848 (Entrez Gene)
TGFB1Protein21803 (Entrez Gene)
TGFB1Protein7040 (Entrez Gene)
TGFBR1Protein21803 (Entrez Gene)
TGFBR2Protein21803 (Entrez Gene)
TNFA Protein29949 (Entrez Gene)
TNFAProtein7124 (Entrez Gene)
TNFRProtein7132 (Entrez Gene)
Tgfb1Protein7040 (Entrez Gene)

Annotated Interactions

No annotated interactions