IL19 signaling (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Lung CancerY1034Y1035JAK1Y705STAT3IL19IL20RBTumor-cell induced IL-19 secretion by osteoclastsProliferation ofIL20RB+ tumor cellsPromote the proliferation and invasion of lung fibroblastsIL19TGFB1ACTA2IL20RBIL20RAIdiopathic pulmonary fibrosisS425SMAD3COL1A1TGFBR1TGFBR2PMAPK3IL19PMAPK1Y705STAT3SOCS5STAT3Intimal hyperplasiaPMAPK14Immunological orMechanical injuryVascular SmoothMuscle cellsIL19CYNUSOCS5Involves in theautocrine-negativefeedback to diminish the vascularresponse to injuryCYPNFKBIAIL19Y204T202MAPK3T185Y187MAPK1RELARELANUMMP9IL19IL20RBY705STAT3MUC5ACIL20RAPMAP2K1PMAP2K2Chronic RhinosinusitisIL13IL13RIL17RIL17IL19Induces the MMP9 production by activating ERK and NFκB pathwayin HNECsIL-19 inducesSTAT3-dependentproduction of MUC5ACCardioprotection in dnCREB miceY705Stat3IL19IL20RAIL20RBCardiac dysfunction; Heart failureIL19SOCS1IL20RAIL20RBAllergic rhinitisIL4TNFAIL4RTNFRCCL11PSTAT6Suppression of IL-4-inducedeotaxin production in human nasal fibroblastsReceptorIL19S536NFKB1CCNB1S473AKT1TGFB1Y185T183MAPK8CXCR4MMP1Squamous cell carcinomaY182T180MAPK14PSTAT3Y204T202MAPK3T185Y187MAPK1IL20RAIL20RBProliferation, migrationand colony formationin CE81T cellsLigand IL19Figure LegendA2B ReceptorIn bronchialepithelial cellsPathogenesis of asthma and chronic obstructive pulmonary diseaseAdenosineIL19TNFAMonocytesInflammation responds in human monocytic cell lineIn A549cellsIn HepG2cellsIL19Y701STAT1S727STAT3S473Akt1Y185T183Mapk8Y705Stat3Tgfb1Ccl2TNFAIL10IL20RAIL20RBT202Y204Mapk3T185Y187Mapk1IL19TNFAIL1BIL19IL20RAIL20RBOthersCell survival, cytokine expression and apoptosisInvoled in the development of elevated intraocular pressure in response to inflammationIn M-1cellsIL19IL20RBY705STAT3GranulopoiesisIL-19 secreted from osteocytesIn granulocyte-monocyte progenitor cells and promyelocyte/myelocytesY705STAT3IL19GTPRAC1AngiogenesisT202Y204MAPK3T185Y187MAPK1IL20RAIL20RBAssociated with EC Proliferation, enhanced cell spreading, promotionof EC cord structure formation andmicrovessel formationIL19Y180T182Mapk14Casp3Casp9IL20RAAcute kidney injuryApoptosis inM-1 cellsLigand IL4Ligand TNFALigand IL13Ligand IL17CleavageLigand TGFB1Ligand AdenosinMolecular AssociationDownregulationUpregulationLeads to phosphorylationCytoplasmPhosphositeCYTransportNucleusNUGTPPProteinLeads to through indirect/multiple reactionsIndirect regulation of gene / protein expressionIndirect inhibitionGTPase-activating proteinDirect regulation of gene / protein expressionProteinmRNAProtein/ GeneProtein/ GeneName: IL19 signalingOrganism: Homo sapiens


Description

Schematic representation of IL-19 signaling pathway

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Bibliography

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  1. Hsu YH, Li HH, Sung JM, Chen WT, Hou YC, Chang MS; ''Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury.''; PLoS One, 2013 PubMed Europe PMC Scholia
  2. Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, Walker LA; ''Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner.''; World J Cardiol, 2017 PubMed Europe PMC Scholia
  3. Li X, Huang J, Chen X, Lai X, Huang Z, Li Y, Li S, Chang L, Zhang G; ''''; , PubMed Europe PMC Scholia
  4. Wang Y, Sun S, Wang K, Zhang M, Li M, Zan Y, Huang Q, Wu S, Zhao W, Xu W, Wu J; ''Interleukin-19 Aggravates Pulmonary Fibrosis via Activating Fibroblast through TGF-β/Smad Pathway.''; Mediators Inflamm, 2022 PubMed Europe PMC Scholia
  5. He Y, Luo W, Liu Y, Wang Y, Ma C, Wu Q, Tian P, He D, Jia Z, Lv X, Ma YS, Yang H, Xu K, Zhang X, Xiao Y, Zhang P, Liang Y, Fu D, Yao F, Hu G; ''IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer.''; J Clin Invest, 2022 PubMed Europe PMC Scholia
  6. Jain S, Gabunia K, Kelemen SE, Panetti TS, Autieri MV; ''The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells.''; Arterioscler Thromb Vasc Biol, 2011 PubMed Europe PMC Scholia
  7. Tian Y, Sommerville LJ, Cuneo A, Kelemen SE, Autieri MV; ''Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia.''; Am J Pathol, 2008 PubMed Europe PMC Scholia
  8. Higashino M, Takabayashi T, Takahashi N, Okamoto M, Narita N, Kojima A, Hyo S, Kawata R, Takenaka H, Fujieda S; ''Interleukin-19 downregulates interleukin-4-induced eotaxin production in human nasal fibroblasts.''; Allergol Int, 2011 PubMed Europe PMC Scholia
  9. Keller KE, Yang YF, Sun YY, Walter MR, Wirtz MK; ''Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture.''; Mol Vis, 2019 PubMed Europe PMC Scholia
  10. Zhong H, Wu Y, Belardinelli L, Zeng D; ''A2B adenosine receptors induce IL-19 from bronchial epithelial cells, resulting in TNF-alpha increase.''; Am J Respir Cell Mol Biol, 2006 PubMed Europe PMC Scholia
  11. Hsing CH, Kwok FA, Cheng HC, Li CF, Chang MS; ''Inhibiting interleukin-19 activity ameliorates esophageal squamous cell carcinoma progression.''; PLoS One, 2013 PubMed Europe PMC Scholia
  12. Xiao M, Zhang W, Liu W, Mao L, Yang J, Hu L, Zhang S, Zheng Y, Liu A, Song Q, Li Y, Xiao G, Zou Z, Bai X; ''Osteocytes regulate neutrophil development through IL-19: a potent cytokine for neutropenia treatment.''; Blood, 2021 PubMed Europe PMC Scholia
  13. Lai X, Li X, Chang L, Chen X, Huang Z, Bao H, Huang J, Yang L, Wu X, Wang Z, Bellanti JA, Zheng SG, Zhang G; ''IL-19 Up-Regulates Mucin 5AC Production in Patients With Chronic Rhinosinusitis via STAT3 Pathway.''; Front Immunol, 2019 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129674
Approved
view00:45, 22 May 2024EweitzModified title
127701view01:17, 23 November 2023EweitzOntology Term : 'Interleukin mediated signaling pathway' added !
127700view01:17, 23 November 2023EweitzOntology Term : 'interleukin-19 signaling pathway' added !
127699view01:16, 23 November 2023EweitzModified title
127461view12:45, 6 October 2023JmillanacostaChanged data nodes for graphical shapes in legend
127458view19:40, 4 October 2023Khanspersupdated legend to graphical lines
127418view09:49, 1 October 2023EgonwConverted three interactions that are not mim-conversions not a regular Arrow
127405view11:41, 30 September 2023EgonwAll WikiPathways content is CC0
127404view11:37, 30 September 2023IsabelWassinkOntology Term : 'signaling pathway' added !
127374view23:31, 24 September 2023Rex D A BModified title
127373view23:29, 24 September 2023Rex D A BNew pathway

External references

DataNodes

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Name  ↓Type  ↓Database reference  ↓Comment  ↓
ACTA2Protein59 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
Akt1Protein11651 (Entrez Gene)
CCL11 Protein6356 (Entrez Gene)
CCNB1Protein891 (Entrez Gene)
COL1A1 Protein1277 (Entrez Gene)
CXCR4Protein7852 (Entrez Gene)
Casp3 Protein12367 (Entrez Gene)
Casp9Protein12371 (Entrez Gene)
Ccl2Protein20296 (Entrez Gene)
IL10Protein16176 (Entrez Gene)
IL13 Protein29949 (Entrez Gene)
IL13RProtein53832 (Entrez Gene)
IL17 Protein29949 (Entrez Gene)
IL17RProtein53832 (Entrez Gene)
IL19 Protein29949 (Entrez Gene)
IL19Protein29949 (Entrez Gene)
IL19Protein29949 (NCBI Protein)
IL1BProtein16176 (Entrez Gene)
IL20RAProtein53832 (Entrez Gene)
IL20RBProtein53833 (Entrez Gene)
IL4 Protein3565 (Entrez Gene)
IL4RProtein3566 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
MAP2K1 Protein
MAP2K2Protein
MAPK1 Protein
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MMP1Protein4312 (Entrez Gene)
MMP9Protein
MUC5ACProtein4586 (Entrez Gene)
Mapk1Protein26413 (Entrez Gene)
Mapk14Protein26416 (Entrez Gene)
Mapk3Protein26417 (Entrez Gene)
Mapk8Protein26419 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein
Protein0 (Entrez Gene)
RAC1 Protein5879 (Entrez Gene)
RELA Protein
SMAD3 Protein20848 (Entrez Gene)
SOCS1 GeneProduct8651 (Entrez Gene)
SOCS5Protein9655 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3 Protein6774 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT6Protein6778 (Entrez Gene)
Stat3Protein20848 (Entrez Gene)
TGFB1Protein21803 (Entrez Gene)
TGFB1Protein7040 (Entrez Gene)
TGFBR1Protein21803 (Entrez Gene)
TGFBR2Protein21803 (Entrez Gene)
TNFA Protein29949 (Entrez Gene)
TNFAProtein7124 (Entrez Gene)
TNFRProtein7132 (Entrez Gene)
Tgfb1Protein7040 (Entrez Gene)

Annotated Interactions

No annotated interactions

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