Metabolism of T-2 toxin and HT-2 toxin (Triticum aestivum)

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1-3T-2 toxinHT-2 toxin3-acetyl-T23-trans-feruloyl-T23-trans-isoferuloyl-T2HT2-3-glucoside15-acetyl-T2-tretraol-3-glucosideT2-triol-3-glucoside3'hydroxy-HT2-3-glucosidedehydro-HT2-3-glucosideHT2-3-di-(1,6)-glucosideHT2-3-di-(1,4)-glucosideHT2-3-malonyl-glucoside3'hydroxy-HT2-3-malonyl-glucoside


Description

The T-2 (also T2) toxin is cause of food poisoning. Metabolisation to HT-2 is reported as a detoxification mechanism in mammals. This pathway describes the mycotoxin metabolism pathway of T-2 in wheat with putative biotransformation products. Compounds where converted into identifiers using the 2D drawings in Figure 4 from Nathanail et al. 2015. Structure elucidation is detailed in Meng-Reiterer et al. 2015.

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Bibliography

  1. Meng-Reiterer J, Bueschl C, Rechthaler J, Berthiller F, Lemmens M, Schuhmacher R; ''Metabolism of HT-2 Toxin and T-2 Toxin in Oats.''; Toxins (Basel), 2016 PubMed Europe PMC Scholia
  2. Nathanail AV, Varga E, Meng-Reiterer J, Bueschl C, Michlmayr H, Malachova A, Fruhmann P, Jestoi M, Peltonen K, Adam G, Lemmens M, Schuhmacher R, Berthiller F; ''Metabolism of the Fusarium Mycotoxins T-2 Toxin and HT-2 Toxin in Wheat.''; J Agric Food Chem, 2015 PubMed Europe PMC Scholia
  3. Meng-Reiterer J, Varga E, Nathanail AV, Bueschl C, Rechthaler J, McCormick SP, Michlmayr H, Malachová A, Fruhmann P, Adam G, Berthiller F, Lemmens M, Schuhmacher R; ''Tracing the metabolism of HT-2 toxin and T-2 toxin in barley by isotope-assisted untargeted screening and quantitative LC-HRMS analysis.''; Anal Bioanal Chem, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129445view11:56, 20 April 2024EgonwModified description
129444view11:53, 20 April 2024EgonwAdded a third paper, explaining the structure elucidation.
129443view11:50, 20 April 2024EgonwModified description
129442view11:32, 20 April 2024EgonwLast two identifiers
129441view11:17, 20 April 2024EgonwAnother metabolite ID and an additional article
129440view11:10, 20 April 2024EgonwTwo more
129439view10:55, 20 April 2024EgonwFour more (new) metabolite identifiers
129438view08:54, 20 April 2024EgonwFigured out three more identifiers
129437view08:26, 20 April 2024EgonwAdded the missing literature reference
129433view12:12, 19 April 2024JmillanacostaOntology Term : 'toxic secondary metabolite metabolic pathway' added !
129426view07:39, 18 April 2024MaintBotTypo fix
127679view23:13, 21 November 2023EweitzModified title
127673view20:47, 18 November 2023EgonwAdded two key identifiers
127614view17:06, 7 November 2023EgonwAll metabolites drawn now
127606view10:28, 7 November 2023EgonwCorrect species
127605view09:46, 7 November 2023EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
15-acetyl-T2-tretraol-3-glucosideMetaboliteQ125536699 (Wikidata)
3'hydroxy-HT2-3-glucosideMetaboliteQ125536590 (Wikidata)
3'hydroxy-HT2-3-malonyl-glucosideMetaboliteQ125536679 (Wikidata)
3-acetyl-T2Metabolite49796734 (PubChem-compound)
3-trans-feruloyl-T2Metabolite165362807 (PubChem-compound)
3-trans-isoferuloyl-T2MetaboliteQ125535949 (Wikidata)
HT-2 toxinMetaboliteCHEBI:138861 (ChEBI)
HT2-3-di-(1,4)-glucosideMetaboliteQ125536763 (Wikidata)
HT2-3-di-(1,6)-glucosideMetaboliteQ125536762 (Wikidata)
HT2-3-glucosideMetaboliteQ125536588 (Wikidata)
HT2-3-malonyl-glucosideMetaboliteQ125536677 (Wikidata)
T-2 toxinMetaboliteCHEBI:9381 (ChEBI)
T2-triol-3-glucosideMetaboliteQ125536589 (Wikidata)
dehydro-HT2-3-glucosideMetaboliteQ125536591 (Wikidata)

Annotated Interactions

No annotated interactions

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