PGK1, PKM2, KHKC/KHKA acting as protein kinases (Homo sapiens)
From WikiPathways
Description
This pathway shows the variable role of metabolic kinases, PGK1, PKM1 and KHKC/KHKA, acting as protein kinases. They are able to phosphorylate and thereby activate second messenger enzymes, which greatly influence cellular functions. This Pathway is based on Figure 1 of the paper "Metabolic Kinases Moonlighting as Protein Kinases" PMID: 29463470.
Quality Tags
Ontology Terms
Saving...Bibliography
View all... |
- Jiang Y, Wang Y, Wang T, Hawke DH, Zheng Y, Li X, Zhou Q, Majumder S, Bi E, Liu DX, Huang S, Lu Z; ''PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells.''; Nat Commun, 2014 PubMed Europe PMC Scholia
- He CL, Bian YY, Xue Y, Liu ZX, Zhou KQ, Yao CF, Lin Y, Zou HF, Luo FX, Qu YY, Zhao JY, Ye ML, Zhao SM, Xu W; ''Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1.''; Sci Rep, 2016 PubMed Europe PMC Scholia
- Liang J, Cao R, Wang X, Zhang Y, Wang P, Gao H, Li C, Yang F, Zeng R, Wei P, Li D, Li W, Yang W; ''Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2.''; Cell Res, 2017 PubMed Europe PMC Scholia
- Li X, Qian X, Lu Z; ''Fructokinase A acts as a protein kinase to promote nucleotide synthesis.''; Cell Cycle, 2016 PubMed Europe PMC Scholia
- Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z; ''Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy.''; Mol Cell, 2017 PubMed Europe PMC Scholia
- Cheng TY, Yang YC, Wang HP, Tien YW, Shun CT, Huang HY, Hsiao M, Hua KT; ''Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein.''; Oncogene, 2018 PubMed Europe PMC Scholia
- Xia L, Qin K, Wang XR, Wang XL, Zhou AW, Chen GQ, Lu Y; ''Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells.''; Oncotarget, 2017 PubMed Europe PMC Scholia
- Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Alfred Yung WK, Lu Z; ''PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.''; Cell, 2012 PubMed Europe PMC Scholia
- Li X, Qian X, Peng LX, Jiang Y, Hawke DH, Zheng Y, Xia Y, Lee JH, Cote G, Wang H, Wang L, Qian CN, Lu Z; ''A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation.''; Nat Cell Biol, 2016 PubMed Europe PMC Scholia
- Jiang Y, Li X, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, Wei C, Guo F, Chen Y, Lu Z; ''PKM2 regulates chromosome segregation and mitosis progression of tumor cells.''; Mol Cell, 2014 PubMed Europe PMC Scholia
- Li X, Zheng Y, Lu Z; ''PGK1 is a new member of the protein kinome.''; Cell Cycle, 2016 PubMed Europe PMC Scholia
- Gao X, Wang H, Yang JJ, Liu X, Liu ZR; ''Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.''; Mol Cell, 2012 PubMed Europe PMC Scholia
- Wei Y, Wang D, Jin F, Bian Z, Li L, Liang H, Li M, Shi L, Pan C, Zhu D, Chen X, Hu G, Liu Y, Zhang CY, Zen K; ''Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23.''; Nat Commun, 2017 PubMed Europe PMC Scholia
- Li X, Jiang Y, Meisenhelder J, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, He J, Hunter T, Wang L, Lu Z; ''Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.''; Mol Cell, 2016 PubMed Europe PMC Scholia
- Yang W, Lu Z; ''Pyruvate kinase M2 at a glance.''; J Cell Sci, 2015 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| 1,3-BPG | Metabolite | HMDB0001270 (HMDB)  | |
| 3-PG | Metabolite | HMDB0000807 (HMDB) | |
| AKT1S1 | Protein | Q96B36 (Uniprot-TrEMBL) | |
| Apoptosis | Pathway | WP254 (WikiPathways) | |
| Autophage | Pathway | ||
| Bcl2 | Protein | Q9JJV8 (Uniprot-TrEMBL) | |
| Beclin1 | Protein | Q14457 (Uniprot-TrEMBL) | |
| Bub3 | Protein | O43684 (Uniprot-TrEMBL) | |
| Cell invasion | Pathway | ||
| Cytokinesis | Pathway | ||
| De Novo nucleic acid synthesis | Pathway | ||
| Exosome secretion | Pathway | ||
| F1-P | Metabolite | HMDB0060467 (HMDB) | |
| Fructose | Metabolite | HMDB0000660 (HMDB) | |
| Gene transcription | Pathway | ||
| Genomic instability | Pathway | ||
| Glucose | Metabolite | HMDB0000122 (HMDB) | |
| H2AX | Protein | P16104 (Uniprot-TrEMBL) | |
| H3 | Protein | P84243 (Uniprot-TrEMBL) | |
| KHKA | GeneProduct | P50053 (Uniprot-TrEMBL) | |
| KHKC | GeneProduct | P50053 (Uniprot-TrEMBL) | |
| Lactate | Metabolite | HMDB0000190 (HMDB) | |
| MLC2 | Protein | P10916 (Uniprot-TrEMBL) | |
| Mitochondrial pyruvate metabolism | Pathway | ||
| Mitosis | Pathway | ||
| PAK2 | Protein | Q13177 (Uniprot-TrEMBL) | |
| PDHK1 | Protein | Q15118 (Uniprot-TrEMBL) | |
| PEP | Metabolite | HMDB0000263 (HMDB) | |
| PGK1 | GeneProduct | P00558 (Uniprot-TrEMBL) | |
| PKM2 | GeneProduct | P14618 (Uniprot-TrEMBL) | |
| PRPS1 | Protein | P60891 (Uniprot-TrEMBL) | |
| Pyruvate | Metabolite | HMDB0000243 (HMDB) | |
| SNAP-23 | Protein | O00161 (Uniprot-TrEMBL) | |
| STAT3 | Protein | P40763 (Uniprot-TrEMBL) | |
| mTOR1 activation | Pathway |
Annotated Interactions
No annotated interactions
