Wnt/Beta-catenin signaling inhibitors in current and past clinical trials (Homo sapiens)

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1AcylationPORCNAPCCGX-1321CK1OMP-18R5WNT-974WNTCBPCTNNB1OMP-54f28OTSA101-DTPA-90YGSK3ETC-1922159LRP5TCFAXINSM08502FrizzledRXC004PRI 724LRP6DVLPPPWNTAcCTNNB1WNT


Description

Wnt/Beta-catenin signaling inhibitors in current and past clinical trials

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Quality Tags

Ontology Terms

 

Bibliography

  1. Jung YS, Park JI; ''Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex.''; Exp Mol Med, 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128747view07:45, 21 February 2024EgonwAdded a missing Wikidata identifier
128746view07:38, 21 February 2024EgonwReplaced an replaced Wikidata identifier
128745view07:35, 21 February 2024EgonwUpdated the Ensembl data sources
128744view06:51, 21 February 2024EgonwUpdated the UniProt data source
128652view21:07, 17 February 2024AlexanderPicoAdded phosphorylation of LRP6
128651view21:03, 17 February 2024AlexanderPicoadded LRP5/6; fixed interactions; economized layout
128650view20:40, 17 February 2024AlexanderPicofixed WNT, labelled Ac, removed states; will add LRP5/6 and new states
128649view20:26, 17 February 2024AlexanderPicoOntology Term : 'Wnt signaling pathway' added !
128648view20:26, 17 February 2024AlexanderPicoOntology Term : 'signaling pathway' added !
128493view08:54, 7 February 2024AndraCompleted the pathways as depicted in https://www.nature.com/articles/s41392-022-01042-7
128492view07:43, 7 February 2024AndraNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APCGeneProduct
AXINGeneProduct
CBPGeneProductQ92793 (Uniprot-TrEMBL)
CGX-1321MetaboliteQ124448546 (Wikidata)
CK1GeneProduct
CTNNB1GeneProductENSG00000168036 (Ensembl)
DVLGeneProduct
ETC-1922159MetaboliteQ124448578 (Wikidata)
FrizzledProteinIPR000539 (InterPro)
GSK3GeneProduct
LRP5GeneProductENSG00000162337 (Ensembl)
LRP6GeneProductENSG00000070018 (Ensembl)
OMP-18R5MetaboliteQ7915216 (Wikidata)
OMP-54f28MetaboliteQ124625115 (Wikidata)
OTSA101-DTPA-90YMetaboliteQ124449028 (Wikidata)
PORCNGeneProductENSG00000102312 (Ensembl)
PRI 724MetaboliteQ123515698 (Wikidata)
RXC004MetaboliteQ124439695 (Wikidata)
SM08502MetaboliteQ124448796 (Wikidata)
TCFGeneProduct
WNT-974Metabolite46926973 (PubChem-compound)
WNTGeneProductIPR005817 (InterPro)

Annotated Interactions

No annotated interactions

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