Acetaminophen in analgesia and antipyresis (Homo sapiens)

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Spinal cord2LiverGABAergic neuronPeriaqueductal gray (PAG)Rostral ventromedial medulla (RVM)GABAHTR1A1AcetaminophenAntipyresisPTGS1AM404CB11,4-benzoquinonePTGS2FAAHEndocannabinoiddegradationEndocannabinoidreuptakeEndocannabinoidconcentration(anandimade and 2-AG)TRPV1CACNA1HTRPA1KCNQ2KCNQ3AnalgesiaHyperpolarizationSerotonergic neuronAnalgesiaAntipyresisBlood pressureAnticonvulsant effectAnalgesiaPeripheral nervous system (PNS)Central nervous system (CNS)LegendIncreaseDecrease??DescendingserotonergicfibersNAPQI


Description

Plausible mechanisms of action for the pain-relieving and fever-reducing effects of acetaminophen, also known as paracetemol, Tylenol, or panadol. This is based on Figure 2 of https://doi.org/10.1111/1440-1681.13392.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bonnefont J, Chapuy E, Clottes E, Alloui A, Eschalier A; ''Spinal 5-HT1A receptors differentially influence nociceptive processing according to the nature of the noxious stimulus in rats: effect of WAY-100635 on the antinociceptive activities of paracetamol, venlafaxine and 5-HT.''; Pain, 2005 PubMed Europe PMC Scholia
  2. Przybyla GW, Szychowski KA, Gminski J; ''Paracetamol - An old drug with new mechanisms of action.''; , 2021

History

View all...
CompareRevisionActionTimeUserComment
129040view01:00, 9 March 2024EweitzOrder tissues to back to restore gene, metabolite node clickability
129037view14:00, 8 March 2024EweitzClarify tissue containment
129036view13:51, 8 March 2024EweitzFix NAPQI type, identify nodes, refine interaction layout
129035view13:42, 8 March 2024EweitzSpecify 5-HT to HTR1A, cite and comment on source chain
129034view13:21, 8 March 2024EweitzDepict axon / dendrite interactions
129033view13:09, 8 March 2024EweitzFix reference ("Query PubMed" shows title, but site renders empty title)
129032view03:23, 8 March 2024EweitzAdd more increase / decrease arrows, depict uncertainty
129031view03:15, 8 March 2024EweitzOntology Term : 'neuron' added !
129030view03:14, 8 March 2024EweitzOntology Term : 'serotonergic neuron' added !
129029view03:14, 8 March 2024EweitzOntology Term : 'GABAergic neuron' added !
129028view03:14, 8 March 2024EweitzOntology Term : 'drug pathway' added !
129027view03:13, 8 March 2024EweitzOntology Term : 'paracetamol response pathway' added !
129026view03:13, 8 March 2024EweitzOntology Term : 'paracetamol drug pathway' added !
129025view03:10, 8 March 2024EweitzAdd increase and decrease arrows, and legend
129024view02:49, 8 March 2024EweitzRefine layers, thickness, widths
129023view02:42, 8 March 2024EweitzThicken borders
129022view02:38, 8 March 2024EweitzLabel tissues / systems, color borders
129021view02:23, 8 March 2024EweitzEconomize layout
129020view02:10, 8 March 2024EweitzAdd reference
129019view02:08, 8 March 2024EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,4-benzoquinoneMetabolite16509 (ChEBI) "p-BQ, benzoquinone" per source (DOI: 10.1111/1440-1681.13392)
AM404MetaboliteQ4652517 (Wikidata)
AcetaminophenMetabolite46195 (ChEBI)
AnalgesiaQ484785 (Wikidata)
Anticonvulsant effectQ576618 (Wikidata)
AntipyresisQ582582 (Wikidata)
Blood pressureQ82642 (Wikidata)
CACNA1HGeneProductENSG00000196557 (Ensembl) "T-type cav 3.2" per source (DOI: 10.1111/1440-1681.13392)
CB1Metabolite73416 (ChEBI)
Endocannabinoid

concentration

(anandimade and 2-AG)
Endocannabinoid degradation
Endocannabinoid reuptake
FAAHGeneProductENSG00000117480 (Ensembl)
GABAMetabolite16865 (ChEBI)
HTR1AGeneProductENSG00000178394 (Ensembl) "HT-5" per main source; specified as "5-HT1A" (officially HTR1A) in PMID 15777873 cited in main source.
HyperpolarizationQ1355864 (Wikidata)
KCNQ2GeneProductENSG00000075043 (Ensembl) "Kv7.2" per source (DOI: 10.1111/1440-1681.13392)
KCNQ3GeneProductENSG00000184156 (Ensembl) "Kv7.3" per source (DOI: 10.1111/1440-1681.13392)
NAPQIMetabolite29132 (ChEBI) "p-BQ, benzoquinone" per source (DOI: 10.1111/1440-1681.13392)
PTGS1GeneProductENSG00000095303 (Ensembl) "COX1" per source
PTGS2GeneProductENSG00000073756 (Ensembl) "COX2" per source
TRPA1GeneProductENSG00000104321 (Ensembl)
TRPV1GeneProductENSG00000196689 (Ensembl)

Annotated Interactions

No annotated interactions

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