Cirgarette Smoke Induced Lung Fibrosis (Homo sapiens)

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FibrosisCigarette smoke exposureRegenerationandnormal lung functionCollagen accumulationCollagen biosynthesisand modifying enzymesGrowth factor releaseRelease ofpro-inflammatory mediatorsIncrease of ROSLung epthelial cellsNF-kB pathwayIncreased activation of Nuclear factor kappa B (NF-kB)Oxidative stress and ROSOverview ofinflammatory mediators


Description

Chronic cigarette smoke exposure induced lung fibrosis

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Bibliography

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History

CompareRevisionActionTimeUserComment
129160view09:59, 13 March 2024BurritacoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Cigarette smoke exposure
Collagen accumulation68 (Other)
Collagen biosynthesis

and

modifying enzymes		PathwayWP2725 (WikiPathways)
Fibrosis1276 (Other)
Growth factor release
Increase of ROS
Increased activation

of 

Nuclear factor kappa B
(NF-kB)		Complex1172 (Other)
Lung epthelial cells
NF-kB pathwayPathwayWP4562 (WikiPathways)
Overview of

inflammatory

mediators		PathwayWP5095 (WikiPathways)
Oxidative stress

and

ROS		PathwayWP554 (WikiPathways)
Regeneration

and

normal lung function
Release of

pro-inflammatory

mediators		1469 (Other)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5450"
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