Cirgarette Smoke Induced Lung Fibrosis (Homo sapiens)

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Cigarette smoke exposureCollagen biosynthesisand modifying enzymesRelease ofpro-inflammatory mediatorsIncrease of ROSOxidative stress and ROSGrowth factor releaseLung epithelial cellsRegenerationandnormal lung functionOverview ofinflammatory mediatorsNF-kB pathwayFibrosisCollagen accumulationIncreased activation ofnuclear factor kappa B (NF-kB)


Description

Chronic cigarette smoke exposure induced lung fibrosis

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History

CompareRevisionActionTimeUserComment
129277view13:10, 17 March 2024BurritacoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Cigarette smoke exposure
Collagen accumulation68 (Other)
Collagen biosynthesis

and

modifying enzymes
PathwayWP2725 (WikiPathways)
Fibrosis1276 (Other)
Growth factor release
Increase of ROS
Increased activation

of nuclear factor kappa B

(NF-kB)
Complex1172 (Other)
Lung epithelial cells
NF-kB pathwayPathwayWP4562 (WikiPathways)
Overview of

inflammatory

mediators
PathwayWP5095 (WikiPathways)
Oxidative stress

and

ROS
PathwayWP554 (WikiPathways)
Regeneration

and

normal lung function
Release of

pro-inflammatory

mediators
1469 (Other)

Annotated Interactions

No annotated interactions

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