Cigarette smoke induced lung fibrosis (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Regeneration and normal lung functionLung epithelial cellsNF-kB pathwayFibrosisCigarette smoke exposureCollagen biosynthesisand modifying enzymesIncrease of ROSOverview of inflammatory mediatorsIncreased activation of NF-kBCollagen accumulationRelease ofpro-inflammatory mediatorsGrowth factor releaseOxidative stress and ROSName: Cigarette smoke induced lung fibrosisOrganism: Homo sapiens


Description

Chronic cigarette smoke exposure induced lung fibrosis

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Quality Tags

Image:Wplogo_31.pngCommunity: Adverse Outcome Pathways

Ontology Terms

Cell Type : podocyte
 

Bibliography

  1. Makena P, Kikalova T, Prasad GL, Baxter SA; ''Oxidative Stress and Lung Fibrosis: Towards an Adverse Outcome Pathway.''; Int J Mol Sci, 2023 PubMed Europe PMC Scholia
  2. Estornut C, Milara J, Bayarri MA, Belhadj N, Cortijo J; ''Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis.''; Front Pharmacol, 2021 PubMed Europe PMC Scholia
  3. Ding R, Ren X, Sun Q, Sun Z, Duan J; ''An integral perspective of canonical cigarette and e-cigarette-related cardiovascular toxicity based on the adverse outcome pathway framework.''; J Adv Res, 2023 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135749view13:52, 8 November 2024EweitzModified title
135744
AOP
view13:00, 6 November 2024Marvin M2added literature references and visual cleanup
135743view12:33, 6 November 2024Marvin M2added KE IDs
135742view12:26, 6 November 2024Marvin M2Ontology Term : 'pulmonary fibrosis' added !
129277view13:10, 17 March 2024BurritacoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
Cigarette smoke exposure
Collagen accumulationEvent68 (AOP-Wiki KE)
Collagen biosynthesis and modifying enzymesPathwayWP2725 (WikiPathways)
FibrosisEvent1276 (AOP-Wiki KE)
Growth factor release
Increase of ROS
Increased activation of NF-kBEvent1172 (AOP-Wiki KE)
Lung epithelial cells
NF-kB pathwayPathwayWP4562 (WikiPathways)
Overview of inflammatory mediatorsPathwayWP5095 (WikiPathways)
Oxidative stress and ROSPathwayWP554 (WikiPathways)
Regeneration and normal lung function
Release of pro-inflammatory mediators1469 (AOP-Wiki KE)

Annotated Interactions

No annotated interactions

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