Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis - Carbon Nanotubes (Homo sapiens)

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Increased, secretion of proinflammatory mediatorsType II Interferon Increased, recruitment of inflammatory cellsAccumulation, CollagenSubstance interaction with lung cells Loss of alveolar capillary membrane integrityPulmonary fibrosisTNF-alpha Increased, fibroblast proliferation and myofibroblast differentiation Increased, activation of T (T) helper (h) type 2 cellsInflammatory cytokinesApoptosis


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History

CompareRevisionActionTimeUserComment
129282view12:56, 19 March 2024SamBruss
129281view00:09, 19 March 2024SamBrussNew pathway

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DataNodes

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NameTypeDatabase referenceComment
Increased, activation of T (T) helper (h) type 2 cells
Increased, fibroblast proliferation and myofibroblast differentiation
Loss of alveolar capillary membrane integrity
Accumulation, Collagen
ApoptosisPathwayWP254 (WikiPathways)
Increased, recruitment of inflammatory cells
Increased, secretion of proinflammatory mediators
Inflammatory cytokinesPathwayWP5095 (WikiPathways)
Pulmonary fibrosis
Substance interaction with lung cells
TNF-alphaPathwayWP231 (WikiPathways)
Type II Interferon PathwayWP619 (WikiPathways)

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