PPARα activation leading to hepatocellular adenomas and carcinomas (Homo sapiens)
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Description
PFAS interaction with PPARalpha leading to liver carcinoma and liver steatosis
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DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| Increase, cell proliferation (hepatocytes) | |||
| Branched-chain amino acid catabolism | Pathway | WP3556 (WikiPathways)  | |
| Cell cycle | Pathway | 1393 (WikiPathways) | |
| Increase, Clonal Expansion of Altered Hepatic Foci | |||
| Increase, Phenotypic enzyme activity | |||
| Increase, hepatocellular adenomas and carcinomas | |||
| KE10106: Fatty Acid Lysis | Event | 10106 (AOP-Wiki KE) | |
| KE140: Decreased, HSD17B10 expression | Event | 140 (AOP-Wiki KE) | |
| KE227: Activation, PPARα | Event | 227 (AOP-Wiki KE) | |
| KE291: Accumulation, Triglyceride | Event | 291 (AOP-Wiki KE) | |
| KE345: Liver steatosis | Event | 345 (AOP-Wiki KE) | |
| KE860: Decreased, Mitochondrial Fatty Acid Beta Oxidation | Event | 860 (AOP-Wiki KE) | |
| Lipid Metabolism Pathway | Pathway | WP3965 (WikiPathways) | |
| Liver X receptor pathway | Pathway | 2874 (WikiPathways) | |
| Mitochondrial LC-Fatty Acid Beta-Oxidation | Pathway | WP368 (WikiPathways) | |
| PPAR Alpha Pathway | Pathway | WP2878 (WikiPathways) |
Annotated Interactions
No annotated interactions
