PPARA activation leading to hepatocellular steatosis and carcinomas (Homo sapiens)

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DataNodes

Name	Type	Database reference	Comment
Increase, cell proliferation (hepatocytes)
AMP-activated protein kinase (AMPK) signaling	Pathway	WP1403 (WikiPathways)
Angiopoietin like protein 8 regulatory pathway	Pathway	WP3915 (WikiPathways)
Branched-chain amino acid catabolism	Pathway	WP3556 (WikiPathways)
Cell cycle	Pathway	WP179 (WikiPathways)
Fatty acid biosynthesis	Pathway	WP357 (WikiPathways)
Increase, Clonal Expansion of Altered Hepatic Foci
Increase, Phenotypic enzyme activity
Increase, hepatocellular adenomas and carcinomas
KE10106: Fatty Acid Lysis	Event	10106 (AOP-Wiki KE)
KE116: Activation, FAS	Event	116 (AOP-Wiki KE)
KE140: Decreased, HSD17B10 expression	Event	140 (AOP-Wiki KE)
KE167: Activation, LXR	Event	167 (AOP-Wiki KE)
KE227: Activation, PPARα	Event	227 (AOP-Wiki KE)
KE264: Activation, SREBP-1c	Event	264 (AOP-Wiki KE)
KE291: Accumulation, Triglyceride	Event	291 (AOP-Wiki KE)
KE345: Liver steatosis	Event	345 (AOP-Wiki KE)
KE66: Activation, ChREBP	Event	66 (AOP-Wiki KE)
KE860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	Event	860 (AOP-Wiki KE)
KE89: Synthesis, De Novo FA	Event	89 (AOP-Wiki KE)
Lipid metabolism pathway	Pathway	WP3965 (WikiPathways)
Liver X receptor pathway	Pathway	WP2874 (WikiPathways)
Mitochondrial LC-fatty acid beta-oxidation	Pathway	WP368 (WikiPathways)
PPAR alpha pathway	Pathway	WP2878 (WikiPathways)
Sterol regulatory element-binding protein (SREBP) signaling	Pathway	WP1982 (WikiPathways)

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