Catabolism of skeletal muscle in cachexia (Homo sapiens)

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Bibliography

1. Zhang G, Anderson LJ, Gao S, Sin TK, Zhang Z, Wu H, Jafri SH, Graf SA, Wu PC, Dash A, Garcia JM, Li YP; ''Weight Loss in Cancer Patients Correlates With p38β MAPK Activation in Skeletal Muscle.''; Front Cell Dev Biol, 2021 PubMed Europe PMC Scholia
2. Diep S, Maddukuri M, Yamauchi S, Geshow G, Delk NA; ''Interleukin-1 and Nuclear Factor Kappa B Signaling Promote Breast Cancer Progression and Treatment Resistance.''; Cells, 2022 PubMed Europe PMC Scholia
3. Li YP, Reid MB; ''NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes.''; Am J Physiol Regul Integr Comp Physiol, 2000 PubMed Europe PMC Scholia
4. Stefanetti RJ, Voisin S, Russell A, Lamon S; ''Recent advances in understanding the role of FOXO3.''; F1000Res, 2018 PubMed Europe PMC Scholia
5. Enwere EK, Lacasse EC, Adam NJ, Korneluk RG; ''Role of the TWEAK-Fn14-cIAP1-NF-κB Signaling Axis in the Regulation of Myogenesis and Muscle Homeostasis.''; Front Immunol, 2014 PubMed Europe PMC Scholia
6. Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL; ''Foxo transcription factors inducethe atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.''; Cell, 2004 PubMed Europe PMC Scholia
7. Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL; ''Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.''; Proc Natl Acad Sci U S A, 2001 PubMed Europe PMC Scholia
8. ''JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia''; Am J Physiol Endocrinol Metab., 2012 PubMed Europe PMC Scholia
9. Schiaffino S, Dyar KA, Ciciliot S, Blaauw B, Sandri M; ''Mechanisms regulating skeletal muscle growth and atrophy.''; FEBS J, 2013 PubMed Europe PMC Scholia
10. Goodman CA, McNally RM, Hoffmann FM, Hornberger TA; ''Smad3 induces atrogin-1, inhibits mTOR and protein synthesis, and promotes muscle atrophy in vivo.''; Mol Endocrinol, 2013 PubMed Europe PMC Scholia
11. Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, Burden SJ, Di Lisi R, Sandri C, Zhao J, Goldberg AL, Schiaffino S, Sandri M; ''FoxO3 controls autophagy in skeletal muscle in vivo.''; Cell Metab, 2007 PubMed Europe PMC Scholia
12. Cai D, Frantz JD, Tawa NE Jr, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE; ''IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.''; Cell, 2004 PubMed Europe PMC Scholia
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History

External references

DataNodes

Name	Type	Database reference	Comment
ACVR2A	GeneProduct	ENSG00000121989 (Ensembl)
AKT1	GeneProduct	ENSG00000142208 (Ensembl)
AKT1S1	GeneProduct	ENSG00000204673 (Ensembl)
Autophagy lysosomal system	Pathway	WP4923 (WikiPathways)
CEBPB	GeneProduct	ENSG00000172216 (Ensembl)
CHUK	GeneProduct	ENSG00000213341 (Ensembl)
CPX-3269	Complex	CPX-3269 (Other)	Complex Portal
CPX-503	Complex	CPX-503 (Other)	Complex Portal
EP300	Protein	ENSG00000100393 (Ensembl)
FBXO32	Protein	ENSG00000156804 (Ensembl)
FOXO3	GeneProduct	ENSG00000118689 (Ensembl)
IGF1	GeneProduct	ENSG00000017427 (Ensembl)
IGF1R	GeneProduct	ENSG00000140443 (Ensembl)
IKBKB	GeneProduct	ENSG00000104365 (Ensembl)
IKBKG	GeneProduct	ENSG00000269335 (Ensembl)
IL1A	GeneProduct	ENSG00000115008 (Ensembl)
IL1B	GeneProduct	ENSG00000125538 (Ensembl)
IL1R1	GeneProduct	ENSG00000115594 (Ensembl)
IL6	GeneProduct	ENSG00000136244 (Ensembl)
IL6R	GeneProduct	ENSG00000160712 (Ensembl)
JAK1	GeneProduct	ENSG00000162434 (Ensembl)
MAP1LC3A	GeneProduct	ENSG00000101460 (Ensembl)
MAPK11	GeneProduct	ENSG00000185386 (Ensembl)	p38beta MAPK
MLST8	GeneProduct	ENSG00000167965 (Ensembl)
MSTN	GeneProduct	ENSG00000138379 (Ensembl)
MTOR	GeneProduct	ENSG00000198793 (Ensembl)
NF-kB complex	Complex
NFKB1	GeneProduct	ENSG00000109320 (Ensembl)
NFKB2	GeneProduct	ENSG00000077150 (Ensembl)
NFKBIA	GeneProduct	ENSG00000100906 (Ensembl)
PDK1	GeneProduct	ENSG00000152256 (Ensembl)
PI3K	GeneProduct	PF00454 (Pfam)
Proteasome degradation	Pathway	WP183 (WikiPathways)
Protein synthesis	Pathway	WP107 (WikiPathways)
RELA	GeneProduct	ENSG00000173039 (Ensembl)
RELB	GeneProduct	ENSG00000104856 (Ensembl)
REL	GeneProduct	ENSG00000162924 (Ensembl)
RPTOR	GeneProduct	ENSG00000141564 (Ensembl)
SMAD2	GeneProduct	ENSG00000175387 (Ensembl)
SMAD3	GeneProduct	ENSG00000166949 (Ensembl)
SMAD4	GeneProduct	ENSG00000141646 (Ensembl)
STAT3	GeneProduct	ENSG00000168610 (Ensembl)
TNF	GeneProduct	ENSG00000232810 (Ensembl)
TNFRSF12A	GeneProduct	ENSG00000006327 (Ensembl)
TNFRSF1A	GeneProduct	ENSG00000067182 (Ensembl)
TNFSF12	GeneProduct	ENSG00000239697 (Ensembl)
TRIM63	GeneProduct	ENSG00000158022 (Ensembl)	MuRF1
TRIM63	Protein	ENSG00000158022 (Ensembl)

Annotated Interactions

No annotated interactions