Hallmark of cancer: sustaining proliferative signaling (Homo sapiens)

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7, 33, 371, 12, 1536RETNIL-11TP532513131813, 25182521PI3KRAFPIP3RASGRB2TSC1SHCULK2GDP30FOXO1ERK1FAKRHEBMAP2K1TSC2PIP2SRCPTENGTPSOSRASPIK3CAPIK3CBPIK3CDPIK3CGERK2MAP2K2PRAS40TEL2TTI1MLST8DEPTORMTORRPTOR518MDM2P2135MDM2FGFR2KDRINSRFGFR3IGF1RKITFGFR1EPHA2EGFRCSF1RFGFR4FLT1FLT4NGFRMETPDGFRAPDGFRBTEKFLT3NTRK1NTRK2IL6AKT2STAT3AKT3AKT1IL6RJAK2RELANFKBIARELPNFKB1NFKBIECHUKPIKBKBPIKBKGRELARELNFKB1RELANFKBIARELNFKB1NFKBIETranscriptionActivation of Wnt PathwayProteosomal DegradationJunction plakoglobinc-MYCAML1TCFLEFPPARDGSK3BFrizzledWNTRARAPLZFcyclin-D1BCL9RUNX1T1PMLCatenin beta-1RARAPhosphateLRP6APCCK1LRP5AXINSALL4Catenin beta-1PYGO11, 20KSR111MAP2K212, 2212, 15, 2022, 3612, 15, 2012, 22, 298, 3120, 3112, 1512, 1520, 31ELK1c-FOSc-MYCc-JUNCRAFRASGTP2, 3, 6, 9, 14...MAP2K11SOS212MAPK3GDP1, 8MAPK3SHC11, 8BRAF4SOS11, 8, 10, 20, 23...12GRB24


Description

Proliferative signalling in cancer cells

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Bibliography

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  12. Shaul YD, Seger R; ''The MEK/ERK cascade: from signaling specificity to diverse functions.''; Biochim Biophys Acta, 2007 PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
134341view13:50, 20 July 2024EweitzModified title
134340view13:49, 20 July 2024EweitzModified title
134337view13:40, 20 July 2024EweitzModified title
133258view09:54, 10 June 2024PhilipErnst
130816view14:05, 30 May 2024PhilipErnstNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment

RAS

ProteinENSG00000133703 (Ensembl) RAS protein has three isoforms ( K,N and H RAS). the isoforms differ in ability of activating RAF protein, the isoform which is responsable the most of activating of Raf protein is Kras> also, HRAS has the ability of activating the RAF proteins but less efficiently than KRAS. (PMID: 9727023)
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
AML1GeneProductLRG_482 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
AXINGeneProductENSG00000168646 (Ensembl)
BCL9GeneProductENSG00000116128 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl) IKKa
CK1GeneProductENSG00000113712 (Ensembl)
CRAF GeneProductENSG00000132155 (Ensembl)
CSF1RGeneProductENSG00000182578 (Ensembl)
Catenin beta-1ProteinB4DGU4 (Uniprot-TrEMBL)
DEPTORGeneProductENSG00000155792 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
EPHA2GeneProductENSG00000142627 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FGFR3GeneProductENSG00000068078 (Ensembl)
FGFR4GeneProductENSG00000160867 (Ensembl)
FLT1GeneProductENSG00000102755 (Ensembl)
FLT3GeneProductENSG00000122025 (Ensembl)
FLT4GeneProductENSG00000037280 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FrizzledProteinE5RGK8 (Uniprot-TrEMBL) Frizzled Not Specified
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2GeneProductENSG00000177885 (Ensembl)
GRB2ProteinQ75VX8 (Uniprot-TrEMBL)
GSK3BGeneProductENSG00000082701 (Ensembl)
GTPMetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:37565 (ChEBI)
IGF1RGeneProductENSG00000140443 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl) IKKy
IL-11ProteinENSG00000095752 (EMBL)
IL6GeneProduct3569 (Entrez Gene)
IL6RGeneProduct3570 (Entrez Gene)
INSRGeneProductENSG00000171105 (Ensembl)
JAK2GeneProduct3717 (Entrez Gene)
Junction plakoglobinProteinP14923 (Uniprot-TrEMBL)
KDRGeneProductENSG00000128052 (Ensembl)
KITGeneProductENSG00000157404 (Ensembl)
KSR1GeneProductENSG00000141068 (Ensembl)
LEFGeneProductENSG00000138795 (Ensembl) LEF Not Specified
LRP5GeneProductENSG00000162337 (Ensembl)
LRP6GeneProductENSG00000070018 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK3 GeneProductENSG00000102882 (Ensembl) Also known as ERK
MAPK3GeneProductENSG00000102882 (Ensembl)
  • Also known as ERK
  • Type your comment here
MDM2GeneProductENSG00000135679 (Ensembl)
METGeneProductENSG00000105976 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NFKBIEGeneProductENSG00000146232 (Ensembl)
NGFRGeneProductENSG00000064300 (Ensembl)
NTRK1GeneProductENSG00000198400 (Ensembl)
NTRK2GeneProductENSG00000148053 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
P21GeneProductENSG00000124762 (Ensembl)
PDGFRAGeneProductENSG00000134853 (Ensembl)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3CGGeneProductENSG00000105851 (Ensembl)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLZFGeneProductENSG00000109906 (Ensembl)
PMLGeneProductENSG00000140464 (Ensembl)
PPARDGeneProductENSG00000112033 (Ensembl)
PRAS40GeneProductENSG00000204673 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
PYGOGeneProductENSG00000171016 (Ensembl) PYGO Not Specified
PhosphateMetaboliteHMDB0001429 (HMDB)
RAFGeneProductENSG00000132155 (Ensembl)
RARAGeneProductENSG00000131759 (Ensembl)
RASGeneProductENSG00000174775 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl) RelA
RELGeneProductENSG00000162924 (Ensembl) c-Rel
RETNProteinENSG00000104918 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
RUNX1T1GeneProductENSG00000079102 (Ensembl)
SALL4GeneProductENSG00000101115 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SHCGeneProductENSG00000160691 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STAT3GeneProduct6774 (Entrez Gene)
TCFGeneProductENSG00000071564 (Ensembl) TCF Not Specified
TEKGeneProductENSG00000120156 (Ensembl)
TEL2GeneProductENSG00000100726 (Ensembl)
TP53ProteinENSG00000141510 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
TTI1GeneProductENSG00000101407 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
WNTGeneProductENSG00000125084 (Ensembl) Wnt Not Specified
c-FOSGeneProductENSG00000170345 (Ensembl)
c-JUNGeneProductENSG00000177606 (Ensembl)
c-MYCGeneProductENSG00000136997 (Ensembl)
cyclin-D1ProteinP24385 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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