Molecular pathway for oxidative stress 1.0 (Homo sapiens)

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1-10Anrti-apoptotic gene activationCell-cycle progressionIkBJNK1/2/3RhebInflammationIL-1c-IAPAerobic cell metabolismEnvironmental contaminantsNF-kBiNOSReactive oxigen speciesCOX-2IKKsP53IL-6ATF2PTENIkB ubiquitinationMKK4/7MDM2Radiation protective agentsDifferentiation TNF-alphaTSC1/2Keap-1P38Pink1FoxOBcl-2mTORC1ApoptosisAnti-oxidantsSIRT1P21Chk1MKK3/6PI3KIL-8AngiogenesisCDK2HO-1MSK1NQO-1Cycline-EICAM-1AKTNF-kBCATNOX1ATRNRF-1InflammationMigration/invasionPIP3NRF2CREBAP1PIP2P53Bcl-xLCul3Redox sensetive kinases, transcription factors & receptorsSOD2MAP3K5/ASK1/2GSHPPGTPPPKeap-1Keap-1Cul3NRF2UNRF2 degradationKeap-1Rheb


Description

Oxidative stress pathway

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Ryoichi HAYAKAWA, Teruyuki HAYAKAWA, Kohsuke TAKEDA, Hidenori ICHIJO; ''Therapeutic targets in the ASK1-dependent stress signaling pathways''; NCBI, 2012 PubMed Europe PMC Scholia
  2. Yong Son, Sangduck Kim, Hun-Taeg Chung, Hyun-Ock Pae; ''Reactive oxygen species in the activation of MAP kinases''; NIH, 2013 PubMed Europe PMC Scholia
  3. Michael J Morgan, Zheng-gang Liu; ''Crosstalk of reactive oxygen species and NF-κB signaling''; Nature, 2011 PubMed Europe PMC Scholia
  4. Silvia Trombetti, Elena Cesaro, Rosa Catapano, Raffaele Sessa, Alessandra Lo Bianco, Paola Izzo, Michela Gross; ''Oxidative Stress and ROS-Mediated Signaling in Leukemia: Novel Promising Perspectives to Eradicate Chemoresistant Cells in Myeloid Leukemia''; ResearchGate, 2021 PubMed Europe PMC Scholia
  5. Brittney Joy-Anne Foo, Jie Qing Eu, Jayshree L Hirpara, Shazib Pervaiz; ''Interplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival''; ResearchGate, 2021 PubMed Europe PMC Scholia
  6. Lakhan Kma, Taranga Jyoti Baruah; ''The interplay of ROS and the PI3K/Akt pathway in autophagy regulation''; Wiley, 2021 PubMed Europe PMC Scholia
  7. Danfeng Xue, Xiongming Zhou, Jiaxuan Qiu; ''Emerging role of NRF2 in ROS-mediated tumor chemoresistance''; Elsevier, 2020 PubMed Europe PMC Scholia
  8. Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura, Ken Itoh; ''Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology''; MDPI, 2020 PubMed Europe PMC Scholia
  9. Mira Hammad, Mohammad Raftari, Rute Cesário, Rima Salma, Paulo Godoy, S Noushin Emami, Siamak Haghdoost; ''Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy''; MDPI, 2023 PubMed Europe PMC Scholia
  10. Anuradha Kirtonia, Gautam Sethi, Manoj Garg; ''The multifaceted role of reactive oxygen species in tumorigenesis''; ResearchGate, 2020 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
135312view21:26, 16 August 2024KhanspersOntology Term : 'signaling pathway' added !
135311view21:25, 16 August 2024KhanspersOntology Term : 'oxidative stress response pathway' added !
131777view12:44, 3 June 2024BurritacoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKTGeneProductENSG00000142208 (Ensembl)
AP1GeneProductENSG00000170345 (Ensembl)
ATF2GeneProductENSG00000115966 (Ensembl)
ATRENSG00000175054 (Ensembl)
Aerobic cell metabolism
Angiogenesis
Anrti-apoptotic gene activation
Anti-oxidants
Apoptosis
Bcl-2GeneProductENSG00000171791 (Ensembl)
Bcl-xLGeneProductENSG00000171552 (Ensembl)
CATGeneProductENSG00000121691 (Ensembl)
CDK2GeneProductENSG00000123374 (Ensembl)
COX-2GeneProductENSG00000073756 (Ensembl)
CREBGeneProductENSG00000118260 (Ensembl)
Cell-cycle progression
Chk1GeneProductENSG00000149554 (Ensembl)
Cul3GeneProductENSG00000036257 (Ensembl)
Cycline-EGeneProductENSG00000105173 (Ensembl)
Differentiation
Environmental contaminants
FoxOGeneProductENSG00000150907 (Ensembl)
GSHGeneProductENSG00000169840 (Ensembl)
HO-1GeneProductENSG00000100292 (Ensembl)
ICAM-1GeneProductENSG00000090339 (Ensembl)
IKKsGeneProductENSG00000269335 (Ensembl)
IL-1GeneProductENSG00000115008 (Ensembl)
IL-6GeneProductENSG00000136244 (Ensembl)
IL-8GeneProductENSG00000169429 (Ensembl)
IkB ubiquitinationGeneProduct
IkBGeneProductENSG00000104365 (Ensembl)
Inflammation
JNK1/2/3GeneProductENSG00000107643 (Ensembl)
Keap-1GeneProductENSG00000079999 (Ensembl)
MAP3K5/ASK1/2GeneProductENSG00000197442 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MKK3/6GeneProductENSG00000034152 (Ensembl)
MKK4/7GeneProductENSG00000065559 (Ensembl)
MSK1 GeneProductENSG00000100784 (Ensembl)
Migration/invasion
NF-kBGeneProductENSG00000109320 (Ensembl)
NOX1GeneProductENSG00000007952 (Ensembl)
NQO-1GeneProductENSG00000181019 (Ensembl)
NRF-1GeneProductENSG00000106459 (Ensembl)
NRF2 degradationGeneProduct
NRF2GeneProductENSG00000116044 (Ensembl)
P21 GeneProductENSG00000124762 (Ensembl)
P38GeneProductENSG00000112062 (Ensembl)
P53GeneProductENSG00000141510 (Ensembl)
PI3KGeneProductENSG00000121879 (Ensembl)
PIP2GeneProductENSG00000159763 (Ensembl)
PIP3GeneProductENSG00000074706 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
Pink1GeneProductENSG00000158828 (Ensembl)
Radiation protective agents
Reactive oxigen speciesMetaboliteCHEBI:26523 (ChEBI)
Redox sensetive kinases, transcription factors & receptors
RhebGeneProductENSG00000106615 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
SOD2GeneProductENSG00000291237 (Ensembl)
TNF-alphaGeneProductENSG00000232810 (Ensembl)
TSC1/2GeneProductENSG00000165699 (Ensembl)
c-IAPGeneProduct
iNOSGeneProductENSG00000007171 (Ensembl)
mTORC1GeneProductENSG00000198793 (Ensembl)

Annotated Interactions

No annotated interactions

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