Rotenone metabolism (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none rotenoneCYP3A48′-hydroxyrotenonerotenolone Irotenolone IICYP2C19Name: Rotenone metabolismOrganism: Homo sapiens


Description

Human metabolism of rotenone is mostly happening because of the CYP3A4 and CYP2C19 enzymes, resulting in two 12a-hydroxyrotenone isomers (rotenolone I and rotenolone II) and 8′-hydroxyrotenone.

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Quality Tags

Image:NeedsWork.pngNeeds work

Ontology Terms

 

Bibliography

  1. Caboni P, Sherer TB, Zhang N, Taylor G, Na HM, Greenamyre JT, Casida JE; ''Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease.''; Chem Res Toxicol, 2004 PubMed Europe PMC Scholia
  2. Innos J, Hickey MA; ''Using Rotenone to Model Parkinson's Disease in Mice: A Review of the Role of Pharmacokinetics.''; Chem Res Toxicol, 2021 PubMed Europe PMC Scholia
  3. Fukami JI, Yamamoto I, Casida JE; ''Metabolism of rotenone in vitro by tissue homogenates from mammals and insects.''; Science, 1967 PubMed Europe PMC Scholia
  4. ''Oxidative metabolism of rotenone in mammals, fish, and insects and its relation to selective toxicity''; Journal of Agricultural and Food Chemistry, 1969 DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
135319view07:06, 20 August 2024EgonwModified description
135044view14:54, 1 August 2024EgonwOntology Term : 'xenobiotic metabolic pathway' added !
135043view14:54, 1 August 2024EgonwModified description
135042view14:49, 1 August 2024EgonwAdded the missing info for the DOI
135041view14:46, 1 August 2024EgonwNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
8′-hydroxyrotenoneMetabolite92207 (PubChem-compound)
CYP2C19GeneProductENSG00000165841 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
rotenolone IMetabolite68184 (PubChem-compound)
rotenolone IIMetabolite99189 (PubChem-compound)
rotenoneMetaboliteQ412388 (Wikidata)

Annotated Interactions

No annotated interactions

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