AMPK regulation of mammary milk protein synthesis (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none LysosomeActivatedAMPKMilkproteinsAlphaPRKAA1PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3BetaGammaRPTORMTORMLST8EIF4EBP1EIF4EEIF4G1EIF4A2mTORC1TSC2RHEBRPS6KB1EEF2KEEF2CSN1S1CSN2CSN3Name: AMPK regulation of mammary milk protein synthesisOrganism: Homo sapiens


Description

"AMPK regulates mammary milk protein synthesis: mTORC1 is the master regulator that controls milk protein synthesis in the mammary gland through 4EBP1 and S6K1. AMPK directly inhibits mTORC1 through the phosphorylation of raptor at Ser 792. AMPK also decreases mTOR activity through the phosphorylation of TSC2 (a negative mTORC1 regulator) at Ser1345. The genes encoding as1-casein (CSN1S1), β-casein (CSN2) and κ-casein (CSN3) are also decreased with the activation of AMPK." Derived from Figure 4 in https://pmc.ncbi.nlm.nih.gov/articles/PMC7332552.

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Pathway Ontology : regulatory pathway
 

Bibliography

  1. Wu Z, Tian M, Heng J, Chen J, Chen F, Guan W, Zhang S; ''Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology.''; Front Cell Dev Biol, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135671
Approved
view04:13, 21 October 2024EweitzOntology Term : 'mammary gland epithelial cell' added !
135670view04:12, 21 October 2024EweitzOntology Term : 'adenosine monophosphate-activated protein kinase (AMPK) signaling pathway' added !
135669view04:11, 21 October 2024EweitzAdd label
135668view04:09, 21 October 2024EweitzRefine board dimensions
135667view04:08, 21 October 2024EweitzNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
CSN1S1GeneProductENSG00000126545 (Ensembl)
CSN2GeneProductENSG00000135222 (Ensembl)
CSN3GeneProductENSG00000171209 (Ensembl)
EEF2GeneProductENSG00000167658 (Ensembl)
EEF2KGeneProductENSG00000103319 (Ensembl)
EIF4A2GeneProductENSG00000156976 (Ensembl) "EIF4A" in source
EIF4EBP1GeneProductENSG00000198793 (Ensembl) "4EBP1" in source
EIF4EGeneProductENSG00000151247 (Ensembl)
EIF4G1GeneProductENSG00000114867 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
RHEBGeneProductENSG0000010661 (Ensembl)
RPS6KB1GeneProductENSG00000108443 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)

Annotated Interactions

No annotated interactions

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