Mitochondrial carrier deficiency associated with shuttle disturbances (Homo sapiens)

From WikiPathways

Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none DEE39DEE3TCA cycleOxidative phosphorylationGOT2SLC25A22H+GlutamateH+SLC25A12SLC25A13AspartateOxaloacetate2-oxoglutarateGLUD1AspartateGlutamateMitochondrionCTLN2NICCDDEE82CytoplasmName: Mitochondrial carrier deficiency associated with shuttle disturbancesOrganism: Homo sapiens


Description

Amino acid metabolism in triple-negative breast cancer cells. The glutamine, serine and glycine metabolic pathways are significantly upregulated. The upregulated expression of key genes within the glutamine, serine and glycine metabolic pathways have also been observed in triple-negative breast cancer cells

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Bibliography

  1. Kim SK, Jung WH, Koo JS; ''Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes.''; PLoS One, 2014 PubMed Europe PMC Scholia
  2. Bhutia YD, Babu E, Ramachandran S, Ganapathy V; ''Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs.''; Cancer Res, 2015 PubMed Europe PMC Scholia
  3. Christiaan F. Labuschagne, Niels J.F. van den Broek, Gillian M. Mackay, Karen H. Vousden, Oliver D.K. Maddocks; ''Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells''; https://doi.org/10.1016/j.celrep.2014.04.045, 2014 DOI Scholia
  4. Wang Z, Jiang Q, Dong C; ''Metabolic reprogramming in triple-negative breast cancer.''; Cancer Biol Med, 2020 PubMed Europe PMC Scholia
  5. Kung HN, Marks JR, Chi JT; ''Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.''; PLoS Genet, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
136262
Approved
view01:09, 16 January 2025EweitzNudge alignment
136261view01:08, 16 January 2025EweitzRefine label position
136260view01:07, 16 January 2025EweitzRefine alignment
136259view01:06, 16 January 2025EweitzEconomize layout
136258view01:03, 16 January 2025EweitzRefine graphical layering
136257view01:02, 16 January 2025EweitzTailor node dimensions, refine layout
136256view00:54, 16 January 2025EweitzUse conventional node shapes
136255view00:52, 16 January 2025EweitzStandardize case
136254view00:50, 16 January 2025EweitzEconomize layout
136173view15:50, 21 December 2024EgonwRemoved template comments
136142view16:37, 19 December 2024DaanvanbeekRhea's added, check GLUD1, can go both directoins and NAD or NADP
136139view16:25, 19 December 2024DaanvanbeekAdded Rhea identifiers
136134view15:47, 19 December 2024Daanvanbeeklayout change
136133view15:47, 19 December 2024DaanvanbeekLayout change
136132view15:46, 19 December 2024DaanvanbeekAdded GOT2 disease
136131view15:43, 19 December 2024DaanvanbeekAdded diseases
136126view15:08, 19 December 2024DaanvanbeekNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
2-oxoglutarateMetaboliteHMDB0000208 (HMDB)
AspartateMetaboliteCHEBI:29995 (ChEBI)
GLUD1GeneProductENSG00000148672 (Ensembl)
GOT2GeneProductENSG00000125166 (Ensembl)
GlutamateMetabolite33032 (PubChem-compound)
H+MetaboliteCHEBI:24636 (ChEBI)
OxaloacetateMetaboliteHMDB0000223 (HMDB)
Oxidative phosphorylationPathwayWP111 (WikiPathways)
SLC25A12GeneProductENSG00000115840 (Ensembl) Mitochondrial membrane transporter
SLC25A13GeneProductENSG00000004864 (Ensembl) Mitochondrial membrane transporter
SLC25A22GeneProductENSG00000177542 (Ensembl) Mitochondrial membrane transporter
TCA cyclePathwayWP78 (WikiPathways)

Annotated Interactions

View all...
Source  ↓Target  ↓Type  ↓Database reference  ↓Comment  ↓
2-oxoglutaratemim-conversion21827 (Rhea)
Aspartate70786 (Rhea)
AspartateArrow70786 (Rhea)
AspartateOxaloacetatemim-conversion21827 (Rhea)
Glutamate2-oxoglutaratemim-conversion11613 (Rhea) Maybe also reversed reaction possible through GLUD1, GLUD1 can use both NAD(H) and NADP(H) which are different RHEA entries
GlutamateArrow70786 (Rhea)
GlutamateGlutamatemim-conversion70958 (Rhea)
Glutamatemim-conversion21827 (Rhea)
H+70958 (Rhea)
H+Arrow70958 (Rhea)
Personal tools