From WikiPathways
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none GATA-3 Intestinal Inflammatory Diseases CP and OA S36 Schizophrenia FOXP3 Asthma S489 Ligand Food Allergy RORC IL-5 IL-13 CCR3 COX2 IL-17 MUC5AC Increases Inflammation in colorectal cancer Maintains mucosal immunity Phosphorylation Prevents Inflammatory Diseases Hormone / Drug Inhibiting RA-related inflammation and bone deterioration Alleviates inflammation in antigen induced arthritis Increased inflammation and the development of psoriatic lesions Circadian clock regulates cell immunity Managing Inflammation and joint destruction Leads to multiple reactions Bim and caspase-8 leads to apoptosis Inhibits Airway hyperresponsiveness (AHR),and airway inflammation in Asthma. IRF-1 SNPs (rs10035166, rs2706384, rs2070721) Increased Risk for childhood Allergic Asthma Regulation of gene/protein expression Associated disease: IBD modulates the inflammatory conditions in rheumatoid arthritis Maintains barrier integrity,Limits permeability Increases Colitis CY JQ-1, and 2',FL are used to alleviate Psoriases like inflammation Nucleus Development spontaneous of Autoimmune diseases suppression of Th17 cell-mediated autoimmune responses Increased expression Translocation IFNβ ameliorates RR MS Treatment of Psoriasis Inhibition NU Increases Autophagy markers LC3-11 and P62, hence results in Enhanced Autophagy LEGEND DLL4 NOTCH4 NICD ADAM10 γ-secretase NICD NU CSL NICD CSL NICD CSL MAML1 RORgt Asthma, airway hyperreactivity, airway inflammation, airway epithelial injury and airway smooth muscle thickening. IRF1 SNPs ICAM3 XBP-1 IRF-8 IFN-g RORC TSC2 NOD2 ILT4 Vitamin D [25(OH)D3] IRF-8 RORC IL17 IL23R CCR6 Vitamin D [25(OH)D3] ameliorates inflammation by reducing Th17 cells differentiation in Young Asthmatics Esculetin RORC AKT ERK NFKB IL17 IL23 IL6 IL1B TNFa Inhibition of ERK, AKT, RORC,and NFkB reduces inflammation associated with Acute Lung Injury (ALI). FOXP3 IL2ra CTLA4 P13K/AKT Stage II pulmonary sarcoidosis RORC IL17 GM-CSF IL1 IL6 KC MIP Steroid insensitive neutrophilic airway inflammation IL4Ra R576 GRB2 MAPK C-Raf MKK3 MKK6 ERK1 ERK2 p38MAPK IL6 STAT3 RORC IL17 Airway inflammation, AHR, Asthma IAV TLR2 TLR9 IL23 TGFB STAT3 RORC IL17 Streptococcus pneumoniae IL4 PAMPs PRRs MyD88 RORgt The increased expression of RORgt and decreased expression of Helios in iTreg cells protect against Food Allergy (FA). Helios IL23 RORgt IL17 Act-1 Occulidin TCR CDC42 Pak2 RORgt IL17 Itch S316 Wnt GSK-3 B-Catenin TCF-1 B-Catenin TCF-1 FOXP3 RORgt IL17 B-Catenin CY NU TCR GSK-3 GSK-3 SHP-1/2 PERK-1/2 TSC-1/2 mTORC1 TNFA RORgt RORA IL17A Atg5 RORC TBX21 Atg5 Bim mTORC1 c-MYC Caspase-8 Glycolysis FOXP3 Batch2 RORgt RORA IL17A TNFA LT LTBR IL23 RORgt IL22 Multiple Sclerosis SOCS3 RORC STAT1 IFN IL27 IL12 IL17 IL23 IL17A CCR6 IL23R STAT3 IFNB STAT1 RORC IRF7 IFN IL17A CCR6 IL23R IL27 IL12P35 IL10 IL1B TGFB IL23R DMF IL2 GSH STAT5 ROS P13K FOXP3 AKT TBet RORgt IL17 FOXO1 CD58 CD2 RORgt IL17 Psoriasis S18-000003 IL23 STAT3 RORgt IL17 IL23 IL23R STAT3 RORgt IL17 JQ-1 2`,FL FOSLL PPARg RORC IL17A STAT3 FOXP3 Arthritis Nicotine a7nAch MEK1/2 ERK1/2 RORC IL17A GATA3 IL4 Cpd1 RORgt IL17A IL23 GLK IKKB RORgt RORgt PKCQ AHR AHR AHR RORgt IL17A T-614 IL6 ERK1/2 RAKL MMP3 RORC IL17 IL1B IL6 IL21 IL23 TGFB STAT3 RORC IL17A IL17F IL22 IL23 IL6 JAK 1/2 STAT3 RORgt IL17 FOXP3 JAK 1/2 Inflammatory Diseases Autophagy Mel ROS MT1 MT2 ROR A/B/C LC3-11 P62 LiCl Wnt/B-Catenin TCF1 RORgt IL17 TNFA IL17 TNFA TCF1 RORgt DKK1 Wnt/B-Catenin IL10 IL17F IL17A RORgt BMAL1 IL22 NR1D1 PER3 CRY1 BAX BCL2L11 Circadian and Immunity CIA Receptor Protein mRNA Gene/Protein Decreased expression Protein P CY ER PM Cytoplasm Endoplasmic Reticulum Plasma Membrane Gene/Protein DFM ameliorates multiple sclerosis aHSTC modulates immune responses by suppressing Th17 cells implication in the development of schizophrenia Pathogenic conversion of RORγt+ Tregs in autoimmunity by reduced expression of PTPN2 P P P P P P P P P P CY NU CY NU Name: A network map of RORgt mediated signaling pathway in inflammatory diseases Organism: Homo sapiens
Description
A Network Map of RORgt Signaling Pathway in Inflammatory Diseases
Try the New WikiPathways
View approved pathways at the new wikipathways.org .
Quality Tags
Add description Comment: extensive description needed.
Please help improve this pathway by editing the description. You are allowed to use literature references as a source of inspiration, however please write your own text. Remove this tag when completed.
Annotate nodes Please help improve this pathway by annotating gene, protein and metabolite nodes.
Add references Please help improve this pathway by adding literature references. Remove this tag when completed.
Fix interactions Please help improving this pathway by connecting the ends of interactions to nodes.
Needs work This Pathway is in need of some attention. See the suggested improvements above.
Ontology Terms
Bibliography
No bibliography
History
External references
DataNodes
No datanodes
Annotated Interactions
No annotated interactions
Saving...
