SLC25A46 Pathway (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Cristae FormationMICOS complexAPOOIMMTMICOS13CHCHD6MICOS10APOOLCHCHD3PEMFN2MFN1PSEMC4EMC3EMC6EMC8MMGT1EMC8 complexEMC1EMC7EMC10EMC2OPA1SLC25A46DNM1LOuter membrane fusionMitochondrial fissionInner membrane fusionName: SLC25A46 PathwayOrganism: Homo sapiens


Description

SLC25A46 is one of the genes found in Charcot-Marie-Tooth disorder. This pathway has been analyzed with expression data. View the pathway with expression data visualization: https://classic.wikipathways.org/index.php/Image:SLC25A46-Pathway.pdf#file. Download the pathway with expression data visualization: Image:SLC25A46-Pathway.pdf

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Quality Tags

Image:UnderConstruction.pngUnder construction

Ontology Terms

 

Bibliography

  1. Wan J, Steffen J, Yourshaw M, Mamsa H, Andersen E, Rudnik-Schöneborn S, Pope K, Howell KB, McLean CA, Kornberg AJ, Joseph J, Lockhart PJ, Zerres K, Ryan MM, Nelson SF, Koehler CM, Jen JC; ''Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia.''; Brain, 2016 PubMed Europe PMC Scholia
  2. Janer A, Prudent J, Paupe V, Fahiminiya S, Majewski J, Sgarioto N, Des Rosiers C, Forest A, Lin ZY, Gingras AC, Mitchell G, McBride HM, Shoubridge EA; ''SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome.''; EMBO Mol Med, 2016 PubMed Europe PMC Scholia
  3. Schuettpelz J, Janer A, Antonicka H, Shoubridge EA; ''The role of the mitochondrial outer membrane protein SLC25A46 in mitochondrial fission and fusion.''; Life Sci Alliance, 2023 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
138145view23:54, 17 March 2025SanauwbarMohammadModified description
138144view23:53, 17 March 2025SanauwbarMohammadModified description
138143view23:53, 17 March 2025SanauwbarMohammadModified description
138142view23:51, 17 March 2025SanauwbarMohammadModified description
138141view23:35, 17 March 2025SanauwbarMohammadModified description
138140view23:32, 17 March 2025SanauwbarMohammadModified description
138138view23:26, 17 March 2025SanauwbarMohammadModified description
138136view23:19, 17 March 2025SanauwbarMohammadModified title
138133view13:20, 17 March 2025KatelynCasseresNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
APOOGeneProductENSG00000184831 (Ensembl)
APOOLGeneProductENSG00000155008 (Ensembl)
CHCHD3GeneProductENSG00000106554 (Ensembl)
CHCHD6GeneProductENSG00000159685 (Ensembl)
DNM1LGeneProductENSG00000087470 (Ensembl)
EMC10GeneProductENSG00000161671 (Ensembl)
EMC1GeneProductENSG00000127463 (Ensembl)
EMC2GeneProductENSG00000104412 (Ensembl)
EMC3GeneProductENSG00000125037 (Ensembl)
EMC4GeneProductENSG00000128463 (Ensembl)
EMC6GeneProductENSG00000127774 (Ensembl)
EMC7GeneProductENSG00000134153 (Ensembl)
EMC8 complexComplexCPX-5848Could also be the EMC9 complex. Complex Portal
EMC8GeneProductENSG00000131148 (Ensembl)
IMMTGeneProductENSG00000132305 (Ensembl)
MFN1GeneProductENSG00000171109 (Ensembl)
MFN2GeneProductENSG00000116688 (Ensembl)
MICOS complexComplexCPX-6141Complex Portal
MICOS10GeneProductENSG00000173436 (Ensembl)
MICOS13GeneProductENSG00000174917 (Ensembl)
MMGT1GeneProductENSG00000169446 (Ensembl)
OPA1GeneProductENSG00000198836 (Ensembl)
PEMetaboliteCHEBI:6445 (ChEBI)
PSMetaboliteCHEBI:18303 (ChEBI)
SLC25A46GeneProductENSG00000164209 (Ensembl)

Annotated Interactions

No annotated interactions

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