HSPB3 (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Chromatin RemodellingMyofibrillar Z-membrane and NMJ subcellular localizationMyoblast differentiation via increased muscle gene expressionFacilitates dissociation from nuclear envelopeNucleusEnabling differentiationCBX5DMPKLMNANOTCH3MYODHSPB3LBRLMNB1MEF2CHP1BP3H2AZACTA1DESMYOGHSPB2HSPB3hsa-miR-206hsa-miR-1LBRLMNB1LBRName: HSPB3Organism: Homo sapiens


Description

Role of HSPB3 in Charcot Marie Tooth disease (CMT)

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Quality Tags

Image:UnderConstruction.pngUnder construction

Ontology Terms

Bibliography

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  1. Suzuki A, Sugiyama Y, Hayashi Y, Nyu-i N, Yoshida M, Nonaka I, Ishiura S, Arahata K, Ohno S; ''MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase.''; J Cell Biol, 1998 PubMed Europe PMC Scholia
  2. Ye Q, Worman HJ; ''Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane.''; J Biol Chem, 1994 PubMed Europe PMC Scholia
  3. Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K; ''The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  4. Gagan J, Dey BK, Layer R, Yan Z, Dutta A; ''Notch3 and Mef2c proteins are mutually antagonistic via Mkp1 protein and miR-1/206 microRNAs in differentiating myoblasts.''; J Biol Chem, 2012 PubMed Europe PMC Scholia
  5. Fan JY, Rangasamy D, Luger K, Tremethick DJ; ''H2A.Z alters the nucleosome surface to promote HP1alpha-mediated chromatin fiber folding.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  6. Solovei I, Wang AS, Thanisch K, Schmidt CS, Krebs S, Zwerger M, Cohen TV, Devys D, Foisner R, Peichl L, Herrmann H, Blum H, Engelkamp D, Stewart CL, Leonhardt H, Joffe B; ''LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation.''; Cell, 2013 PubMed Europe PMC Scholia
  7. Sugiyama Y, Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye MM, Tsui SK, Yoshida S, Ohno S; ''Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  8. Tiago T, Hummel B, Morelli FF, Basile V, Vinet J, Galli V, Mediani L, Antoniani F, Pomella S, Cassandri M, Garone MG, Silvestri B, Cimino M, Cenacchi G, Costa R, Mouly V, Poser I, Yeger-Lotem E, Rosa A, Alberti S, Rota R, Ben-Zvi A, Sawarkar R, Carra S; ''Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor.''; Cell Death Dis, 2021 PubMed Europe PMC Scholia
  9. Ye Q, Callebaut I, Pezhman A, Courvalin JC, Worman HJ; ''Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  10. Dodou E, Xu SM, Black BL; ''mef2c is activated directly by myogenic basic helix-loop-helix proteins during skeletal muscle development in vivo.''; Mech Dev, 2003 PubMed Europe PMC Scholia
  11. Wang DZ, Valdez MR, McAnally J, Richardson J, Olson EN; ''The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development.''; Development, 2001 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
138368view12:50, 1 April 2025OqbehmMYOD directly induces the transcription of MEF2C
138199view17:30, 24 March 2025OqbehmChanged faulty HP1B3 protein name to HP1BP3
138198view15:20, 24 March 2025OqbehmMYOD directly increases NOTCH3 expression
138164view15:08, 19 March 2025OqbehmNew pathway

External references

DataNodes

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Name  ↓Type  ↓Database reference  ↓Comment  ↓
ACTA1GeneProductP68133 (Uniprot-TrEMBL)
CBX5ProteinP45973 (Uniprot-TrEMBL) aka HP1 (heterochromatin protein 1)
DESGeneProductP17661 (Uniprot-TrEMBL)
DMPKProteinQ09013 (Uniprot-TrEMBL)
H2AZProteinP0C0S5 (Uniprot-TrEMBL)
HP1BP3ProteinQ5SSJ5 (Uniprot-TrEMBL) ad
HSPB2ProteinQ16082 (Uniprot-TrEMBL)
HSPB3ProteinQ12988 (Uniprot-TrEMBL)
LBRProteinQ14739 (Uniprot-TrEMBL)
LMNAProteinP02545 (Uniprot-TrEMBL)
LMNB1ProteinP20700 (Uniprot-TrEMBL)
MEF2CProteinQ06413 (Uniprot-TrEMBL)
MYODProteinP15172 (Uniprot-TrEMBL)
MYOGGeneProductP15173 (Uniprot-TrEMBL)
NOTCH3ProteinQ9UM47 (Uniprot-TrEMBL)
hsa-miR-1RnaENSG00000199017 (Ensembl)
hsa-miR-206RnaENSG00000207604 (Ensembl)

Annotated Interactions

No annotated interactions

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