Glycolysis pathway & Krebs Cycle (Homo sapiens)
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Description
Glycolysis and the Krebs cycle (citric acid cycle) are key metabolic pathways involved in cellular respiration. Glycolysis occurs in the cytoplasm and breaks down one molecule of glucose into two molecules of pyruvate, generating a net gain of 2 ATP and 2 NADH. If oxygen is available, pyruvate enters the mitochondria, where it is converted into acetyl-CoA, which then enters the Krebs cycle. The Krebs cycle, occurring in the mitochondrial matrix, further oxidizes acetyl-CoA to produce CO₂, ATP (or GTP), NADH, and FADH₂. These high-energy electron carriers then feed into the electron transport chain, leading to ATP synthesis. Together, glycolysis and the Krebs cycle provide energy and essential intermediates for cellular metabolism.
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Bibliography
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