Wnt signaling in adult hippocampal neurogenesis (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Wnt ligandsHippocampusCA1WNT7AWnt / B-cateninCA1DGMLGCLSGZMatureneuronIntermediateprogenitorcellNeural stemcellNeuroblastImmatureneuronIntermediateprogenitorcellWNT3WNT3AWNT5AFZD1FZD3Wnt / B-cateninWnt / Ca2+Wnt / PCPCCND1NEUROG2NEUROD1PROX1FZD receptorsand co-receptorsWnt signalingcascadesWnt target genesLRP6Type 1Type 2aType 2bType 3Name: Wnt signaling in adult hippocampal neurogenesisOrganism: Homo sapiens


Description

The adult hippocampus generates new neurons in the dentate gyrus of the hippocampus. Type 1 neural stem cells (NSCs) undergo asymmetric division to generate type 2 progenitor cells (subtypes 2a and 2b), which further differentiate into type 3 cells or neuroblasts. These neuroblasts then mature into immature neurons, eventually developing into fully mature granule cells. The lower panel shows the timeframes during which Wnt ligands, Frizzled (FZD) receptors, co-receptors, downstream Wnt signaling pathways, and Wnt target genes are active (refer to main text for specifics). Abbreviations: DG: dentate gyrus, ML: molecular layer, GCL: granule cell layer, SGZ: subgranular zone. Inspired by Figure 1 in [Arredondo](https://pmc.ncbi.nlm.nih.gov/articles/PMC7525004/).

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Cell Type : plant cell
 

Bibliography

  1. Arredondo SB, Valenzuela-Bezanilla D, Mardones MD, Varela-Nallar L; ''Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease.''; Front Cell Dev Biol, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
138496
Approved
view13:39, 12 April 2025EweitzOntology Term : 'neuroblast (sensu Vertebrata)' added !
138495view13:39, 12 April 2025EweitzOntology Term : 'cycling neuroblast (sensu Vertebrata)' added !
138494view13:38, 12 April 2025EweitzOntology Term : 'neuron' added !
138493view13:37, 12 April 2025EweitzOntology Term : 'immature neuron' added !
138492view13:34, 12 April 2025EweitzOntology Term : 'neural stem cell' added !
138491view13:32, 12 April 2025EweitzAdd literature reference
138490view13:31, 12 April 2025EweitzModified description
138489view13:28, 12 April 2025EweitzModified description
138488view12:44, 12 April 2025EweitzAdd identifiers to pathways
138487view11:14, 12 April 2025EweitzEconomize layout
138486view11:13, 12 April 2025Eweitz
138485view11:12, 12 April 2025EweitzRefine cycling graphics
138484view11:10, 12 April 2025EweitzAdd identifiers to genes
138483view10:59, 12 April 2025EweitzIncrease contrast
138482view10:57, 12 April 2025EweitzIncrease text contrast
138481view10:56, 12 April 2025EweitzIncrease height of cells
138480view10:52, 12 April 2025EweitzRefine cell spacing
138479view10:49, 12 April 2025EweitzWiden cells
138478view10:48, 12 April 2025EweitzColor neural cell types
138477view10:39, 12 April 2025EweitzLabel hippocampus
138476view10:35, 12 April 2025EweitzAdd supplementary labels
138475view10:31, 12 April 2025EweitzRefine layering
138474view10:31, 12 April 2025EweitzLabel phased groups
138473view02:07, 12 April 2025EweitzRefine node positions on differentiation timeline
138472view02:00, 12 April 2025EweitzAdd genes and pathways, economize layout
138471view23:32, 11 April 2025EweitzEconomize layout
138470view23:25, 11 April 2025EweitzMove dentate gyrus background
138469view23:21, 11 April 2025EweitzFix Kaavio / PathVisio discrepancy
138468view23:18, 11 April 2025EweitzAdd neuroanatomy graphics
138467view23:03, 11 April 2025EweitzLabel hippocampus regions, refine cell type placements
138464view13:05, 11 April 2025EweitzAdd type 2b intermediate progenitor cell
138463view13:04, 11 April 2025EweitzAdd cell type cycling interactions
138462view13:02, 11 April 2025EweitzShow cell differentiation interactions
138461view13:00, 11 April 2025EweitzRefine cell type labels
138460view12:56, 11 April 2025EweitzNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
CCND1GeneProductENSG00000110092 (Ensembl)
FZD1GeneProductENSG00000157240 (Ensembl)
FZD3GeneProductENSG00000104290 (Ensembl)
LRP6GeneProductENSG00000070018 (Ensembl)
NEUROD1GeneProductENSG00000162992 (Ensembl)
NEUROG2GeneProductENSG00000178403 (Ensembl)
PROX1GeneProductENSG00000117707 (Ensembl)
WNT3AGeneProductENSG00000154342 (Ensembl)
WNT3GeneProductENSG00000108379 (Ensembl)
WNT5AGeneProductENSG00000114251 (Ensembl)
WNT7AGeneProductENSG00000154764 (Ensembl)
Wnt / B-cateninPathwayWP428 (WikiPathways)
Wnt / Ca2+PathwayWP428 (WikiPathways)
Wnt / PCPPathwayWP428 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5536"
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