AOP272_KEs (Homo sapiens)

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History

Compare	Revision	Action	Time	User	Comment
	139098	view	12:22, 20 May 2025	Maick Helmes	Ontology Term : 'lung cancer' added !
	139090	view	11:40, 20 May 2025	Maick Helmes	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
Cell rpoliferation: non-small cell lung cancer	Pathway	WP4255 (WikiPathways)
DNA repair mechanisms	Pathway	WP4946 (WikiPathways)
Direct deposition of energy	Event	1686 (AOP-Wiki KE)	Direct deposition of energy Type your comment here
Energy metabolism	Pathway	WP1541 (WikiPathways)
Inadequate DNA repair	Event	155 (AOP-Wiki KE)	Inadequate DNA repair Type your comment here
Increase, DNA strand breaks	Event	1635 (AOP-Wiki KE)	Increase, DNA strand breaks Type your comment here
Increase, cell proliferation	Event	870 (AOP-Wiki KE)	Increase, cell proliferation Type your comment here
Increase, chromosomal aberrations	Event	1636 (AOP-Wiki KE)	Increase, chromosomal aberrations Type your comment here
Increase, lung cancer	Disease	1556 (AOP-Wiki KE)
Increase, mutations	Event	185 (AOP-Wiki KE)	Increase, mutations Type your comment here

Annotated Interactions

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Source	Target	Type	Database reference	Comment
Direct deposition of energy		Arrow	1983 (AOP-Wiki KER)	Energy deposition leads to INcrease, Lung cancer (moderate evidence)
Direct deposition of energy	Increase, DNA strand breaks	Arrow	1977 (AOP-Wiki KER)	Energy deposition leads to Increase, DNA strand breaks (high evidence) Type your comment here
Direct deposition of energy	Increase, chromosomal aberrations	Arrow	1982 (AOP-Wiki KER)	Energy deposition leads to Increase, Chromosomal aberrations (High evidence) Type your comment here
Direct deposition of energy	Increase, mutations	Arrow	1981 (AOP-Wiki KER)	Energy deposition leads to Increase, Mutations (high evidence) Type your comment here
Inadequate DNA repair	Increase, chromosomal aberrations	Arrow	1912 (AOP-Wiki KER)	Inadequate DNA repair leads to Increase, chromosomal aberrations (high evidence) Type your comment here
Inadequate DNA repair	Increase, mutations	Arrow	164 (AOP-Wiki KER)	Inadequate DNA repair leads to Increase, mutations (Moderate evidence) Type your comment here
Increase, DNA strand breaks	Inadequate DNA repair	Arrow	1911 (AOP-Wiki KER)	Increase, DNA strand breaks leads to Inadequate DNA repair (moderate evidence) Type your comment here
Increase, DNA strand breaks	Increase, chromosomal aberrations	Arrow	1939 (AOP-Wiki KER)	Increase, DNA strand breaks leads to Increase, Chromosomal aberrations (high evidence) Type your comment here
Increase, DNA strand breaks	Increase, mutations	Arrow	1931 (AOP-Wiki KER)	Increase DNA strand breaks leads to Increase, Mutations (high evidence)
Increase, cell proliferation	Increase, lung cancer	Arrow	1980 (AOP-Wiki KER)	Increase, Cell Proliferation leads to Increase, Lung cancer (high evidence) Type your comment here
Increase, chromosomal aberrations	Increase, cell proliferation	Arrow	1979 (AOP-Wiki KER)	Increase, Chromosomal aberrations leads to Increase, Cell Proliferation (moderate evidence) Type your comment here
Increase, chromosomal aberrations	Increase, lung cancer	Arrow	1985 (AOP-Wiki KER)	Increase, Chromosomal aberrations leads to Increase, Lung cancer (moderate understanding) Type your comment here
Increase, mutations	Increase, cell proliferation	Arrow	1978 (AOP-Wiki KER)	Increase, Mutations leads to Increase, Cell Proliferation (high evidence) Type your comment here
Increase, mutations	Increase, lung cancer	Arrow	1984 (AOP-Wiki KER)	Increase Mutations leads to Increase, lung cancer (high evidence) Type your comment here