AOP451_KEs (Homo sapiens)

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Description

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Ontology Terms

Bibliography

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History

Compare	Revision	Action	Time	User	Comment
	139103	view	12:24, 20 May 2025	Maick Helmes	Ontology Term : 'lung cancer' added !
	139095	view	12:00, 20 May 2025	Maick Helmes	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
AO: Lung cancer	Disease	AO 1670 (AOP-Wiki AOP)
Cell proliferation: non-small cell lung cancer	Pathway	4255 (WikiPathways)
Inflammatory cell recruitment	Pathway	4998 (WikiPathways)
KE1115	Event	1115 (AOP-Wiki KE)	Increase, Reactive oxygen species Type your comment here
KE1497	Event	1496 (AOP-Wiki KE)	Increased, secretion of proinflammatory mediators Type your comment here
KE1497	Event	1497 (AOP-Wiki KE)	Increased, recruitment of inflammatory cells Type your comment here
KE1669	Event	1669 (AOP-Wiki KE)	Increased, DNA damage and mutation Type your comment here
KE2006	Event	2006 (AOP-Wiki KE)	Secondary genotoxicity Type your comment here
KE780	Event	780 (AOP-Wiki KE)	Increased, Cytotoxicity (epithelial cells) Type your comment here
KE870	Event	870 (AOP-Wiki KE)	Increase, cell proliferation Type your comment here
MIE1495	Event	1495 (AOP-Wiki AOP)	Substance interaction with the lung resident cell membrane components Type your comment here
Proinflammatory mediators	Pathway	5095 (WikiPathways)
ROS production	Pathway	4269 (WikiPathways)

Annotated Interactions

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Source	Target	Type	Database reference	Comment
KE1115	KE2006	Arrow	2660 (AOP-Wiki KER)	Increase, ROS leads to Secondary cytotoxicity
KE1497	KE1497	Arrow	1703 (AOP-Wiki KER)	Increased proinflammatory mediators leads to recruitment of inflammatory cells (moderate evidence) Type your comment here
KE1497	KE780	Arrow	2658 (AOP-Wiki KER)	Recruitment of inflammatory cells leads to Increase, cytotoxicity (epithelial cells) (moderate evidence) Type your comment here
KE1669	KE870	Arrow	1966 (AOP-Wiki KER)	Increased, DNA damage and mutation leads to Increase, cell proliferation Type your comment here
KE2006	KE1669	Arrow	2661 (AOP-Wiki KER)	Secondary cytotoxicity leads to Increased, DNA damage and mutation
KE780		Arrow	2664 (AOP-Wiki KER)	Increase, Cytotoxicity (epithelial cells) leads to Secondary genotoxicity Type your comment here
KE780	KE1115	Arrow	2659 (AOP-Wiki KER)	Increase, Cytotoxicity (epithelial cells) leads to Increase, ROS
KE870	AO: Lung cancer	Arrow	1967 (AOP-Wiki KER)	Increase, Cell proliferation leads to lung cancer (high evidence)
MIE1495		Arrow	2662 (AOP-Wiki KER)	Substance Interaction with the lung cell mambrane leads to Increase, ROS Type your comment here
MIE1495		Arrow	2663 (AOP-Wiki KER)	Substance interaction with the lung cell mambrane leads to Increased, DNA damage and mutation
MIE1495	KE1497	Arrow	1702 (AOP-Wiki KER)	Substance interaction with the lung cell mambrane leads to Increased proinflammatory mediators (moderate evidence) Type your comment here