Caffeine in myocytes (Homo sapiens)

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Description

Caffeine promotes intracellular calcium release by activating ryanodine receptors on the sarcoplasmic reticulum of skeletal and smooth muscle, enhancing muscle contraction. Inspired by [Figure 1 in Kumar and Lipshultz, 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6915633).

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kumar VHS, Lipshultz SE; ''Caffeine and Clinical Outcomes in Premature Neonates.''; Children (Basel), 2019 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
142308view09:58, 31 December 2025Egonwmim-translocation
142307view09:58, 31 December 2025EgonwAdded a type for myosin
141485view00:13, 16 November 2025EweitzAdd ID
141484view00:11, 16 November 2025EweitzUse graphic element
141483view00:03, 16 November 2025EweitzUse graphic
141482view23:59, 15 November 2025EweitzUse mim-translocation
141409view12:01, 12 November 2025EweitzRemove redundant publication fields
141389view15:04, 11 November 2025EweitzFix unknownTypes lint
141388view14:43, 11 November 2025EweitzChange interaction to graphic
141387view14:37, 11 November 2025EweitzRefine interaction type
141316view13:04, 9 November 2025EweitzAdd literature reference
141315view13:02, 9 November 2025EweitzEconomize layout
141290view20:48, 7 November 2025EweitzOntology Term : 'smooth muscle cell' added !
141289view20:47, 7 November 2025EweitzOntology Term : 'cardiac muscle cell' added !
141288view20:47, 7 November 2025EweitzOntology Term : 'cell of skeletal muscle' added !
141287view20:47, 7 November 2025EweitzOntology Term : 'muscle cell' added !
141286view20:46, 7 November 2025EweitzModified description
141285view20:45, 7 November 2025EweitzModified description
141284view20:33, 7 November 2025EweitzAdd identifier for myosin
141283view20:30, 7 November 2025EweitzAdd gene identifiers
141282view20:26, 7 November 2025EweitzAdd gene identifiers
141281view20:06, 7 November 2025EweitzAdd gene identifiers
141280view19:54, 7 November 2025EweitzNote Ensembl database
141279view19:48, 7 November 2025EweitzAlign nodes
141278view19:46, 7 November 2025EweitzRefine graphics
141277view19:44, 7 November 2025EweitzRefine label placement
141276view19:42, 7 November 2025EweitzSimply explain
141275view19:30, 7 November 2025EweitzRefine graphics
141274view19:29, 7 November 2025EweitzAdd catalysis interaction for translocation
141273view19:27, 7 November 2025EweitzRefine labels, simplify
141272view19:23, 7 November 2025EweitzRefine graphics
141271view19:22, 7 November 2025EweitzRefine graphics
141270view19:20, 7 November 2025EweitzRefine graphics
141269view19:18, 7 November 2025EweitzRefine ryanodine, calcium, troponin interactions
141268view19:08, 7 November 2025EweitzAdd troponin, outline myofilament
141267view18:27, 7 November 2025EweitzImprove guidance for myosin breakout
141266view18:22, 7 November 2025EweitzBind actin to myosin
141265view18:20, 7 November 2025EweitzBind tropomyosin and actin
141264view18:13, 7 November 2025EweitzThin membrane
141263view18:04, 7 November 2025EweitzRefine padding
141262view18:02, 7 November 2025EweitzEnhance myofilament breakouts
141261view17:52, 7 November 2025EweitzAdd myofilament
141260view17:46, 7 November 2025EweitzAdd symmetric myofilament components
141259view17:36, 7 November 2025EweitzUpgrade graphics
141258view16:53, 7 November 2025EweitzAdd conditions
141257view16:51, 7 November 2025EweitzArrange nodes
141256view16:35, 7 November 2025EweitzAdd cardiac and smooth muscle cells, and their myosins
141255view16:28, 7 November 2025EweitzRefine graphics
141254view16:24, 7 November 2025EweitzAdd skeletal muscle cell and its heavy- and light-chain myosin genes
141253view15:58, 7 November 2025EweitzAdd ryanodine receptor, tropomyosin, and actin genes

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTA1GeneProductENSG00000143632 (Ensembl) "A" in source
ACTA2GeneProductENSG00000107796 (Ensembl) "A" in source
ACTBGeneProductENSG00000075624 (Ensembl) "A" in source
ACTC1GeneProductENSG00000159251 (Ensembl) "A" in source
ACTG1GeneProductENSG00000184009 (Ensembl) "A" in source
ACTG2GeneProductENSG00000163017 (Ensembl) "A" in source
Blood vesselsPathwayWP5601 (WikiPathways)
CaffeineMetaboliteCHEBI:27732 (ChEBI)
Ca²⁺MetaboliteCHEBI:29108 (ChEBI)
ChronotropyBiologicalProcessQ14820871 (Wikidata)
Diaphragmatic contractilityBiologicalProcessQ9654 (Wikidata)
Excitation contraction couplingBiologicalProcessQ70691864 (Wikidata)
InotropyBiologicalProcessQ14865584 (Wikidata)
MYH11GeneProductENSG00000133392 (Ensembl) "M" in source
MYH13GeneProductENSG00000006788 (Ensembl) "M" in source
MYH16GeneProductENSG00000293560 (Ensembl) "M" in source
MYH1GeneProductENSG00000109061 (Ensembl) "M" in source
MYH2GeneProductENSG00000125414 (Ensembl) "M" in source
MYH3GeneProductENSG00000109063 (Ensembl) "M" in source
MYH4GeneProductENSG00000264424 (Ensembl) "M" in source
MYH6GeneProductENSG00000197616 (Ensembl) "M" in source
MYH7GeneProductENSG00000092054 (Ensembl) "M" in source
MYH8GeneProductENSG00000133020 (Ensembl) "M" in source
MYL11GeneProductENSG00000180209 (Ensembl) "M" in source
MYL1GeneProductENSG00000168530 (Ensembl) "M" in source
MYL2GeneProductENSG00000111245 (Ensembl) "M" in source
MYL3GeneProductENSG00000160808 (Ensembl) "M" in source
MYL6GeneProductENSG00000092841 (Ensembl) "M" in source
MYL9GeneProductENSG00000101335 (Ensembl) "M" in source
MyocytesPathwayWP5603 (WikiPathways)
MyosinProteinQ271727 (Wikidata)
NeuronsPathwayWP5602 (WikiPathways)
RYR1GeneProductENSG00000196218 (Ensembl) "RyR" in source
RYR2GeneProductENSG00000198626 (Ensembl) "RyR" in source
RYR3GeneProductENSG00000198838 (Ensembl) "RyR" in source
TNNC1GeneProductENSG00000114854 (Ensembl)
TNNC2GeneProductENSG00000101470 (Ensembl)
TNNI1GeneProductENSG00000159173 (Ensembl)
TNNI2GeneProductENSG00000130598 (Ensembl)
TNNI3GeneProductENSG00000129991 (Ensembl)
TNNT1GeneProductENSG00000105048 (Ensembl)
TNNT2GeneProductENSG00000118194 (Ensembl)
TNNT3GeneProductENSG00000130595 (Ensembl)
TPM1GeneProductENSG00000140416 (Ensembl) "TM" in source
TPM2GeneProductENSG00000198467 (Ensembl) "TM" in source
TPM3GeneProductENSG00000143549 (Ensembl) "TM" in source
TPM4GeneProductENSG00000167460 (Ensembl) "TM" in source

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5603"
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