Erythropoiesis (Homo sapiens)

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Description

Erythroid lineage cell differentiation transitions from hematopoietic stem cells (HSCs) through successive erythroid progenitors -- burst-forming unit–erythroid (BFU-E), colony-forming unit–erythroid (CFU-E) -- then proerythroblasts (proEB), basophilic erythroblasts (basoEB), polychromatic erythroblasts (polyEB), and orthochromatic erythroblasts (orthoEB), then and ultimately to reticulocytes, pyrenocytes, and mature red blood cells (RBCs). Stage-specific transcription factors (GATA1, GATA2), surface markers (CD34, CD45, CD71, CD235a), the onset of hemoglobin expression, and other factors are also depicted.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Valent P, Büsche G, Theurl I, Uras IZ, Germing U, Stauder R, Sotlar K, Füreder W, Bettelheim P, Pfeilstöcker M, Oberbauer R, Sperr WR, Geissler K, Schwaller J, Moriggl R, Béné MC, Jäger U, Horny HP, Hermine O; ''Normal and pathological erythropoiesis in adults: from gene regulation to targeted treatment concepts.''; Haematologica, 2018 PubMed Europe PMC Scholia
  2. Huilgol D, Venkataramani P, Nandi S, Bhattacharjee S; ''Transcription Factors That Govern Development and Disease: An Achilles Heel in Cancer.''; Genes (Basel), 2019 PubMed Europe PMC Scholia
  3. Vasiloudis NI, Paschoudi K, Beta C, Georgolopoulos G, Psatha N; ''Epigenetic Regulation of Erythropoiesis: From Developmental Programs to Therapeutic Targets.''; Int J Mol Sci, 2025 PubMed Europe PMC Scholia
  4. Grzywa TM, Nowis D, Golab J; ''The role of CD71(+) erythroid cells in the regulation of the immune response.''; Pharmacol Ther, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141960view15:12, 28 November 2025EweitzAdd gene identifiers
141959view15:06, 28 November 2025EweitzAdd database name
141958view15:01, 28 November 2025EweitzOntology Term : 'hematopoietic stem cell' added !
141957view14:53, 28 November 2025EweitzModified description
141956view14:50, 28 November 2025EweitzOntology Term : 'erythrocyte' added !
141955view14:50, 28 November 2025EweitzOntology Term : 'reticulocyte' added !
141954view14:50, 28 November 2025EweitzOntology Term : 'pyrenocyte' added !
141953view14:49, 28 November 2025EweitzOntology Term : 'orthochromatic erythroblast' added !
141952view14:49, 28 November 2025EweitzOntology Term : 'polychromatophilic erythroblast' added !
141951view14:49, 28 November 2025EweitzOntology Term : 'basophilic erythroblast' added !
141950view14:48, 28 November 2025EweitzOntology Term : 'proerythroblast' added !
141947view14:39, 28 November 2025EweitzOntology Term : 'erythroid progenitor cell' added !
141946view14:39, 28 November 2025EweitzOntology Term : 'erythroid lineage cell' added !
141945view14:28, 28 November 2025EweitzAdd CD79A
141944view14:11, 28 November 2025EweitzUse gene symbol, add TF
141943view14:01, 28 November 2025EweitzEconomize layout
141942view13:58, 28 November 2025EweitzRefine interaction
141941view13:57, 28 November 2025EweitzRefine line type
141940view13:48, 28 November 2025EweitzRefine EPOR/EPO gene distribution, add interactions
141939view13:38, 28 November 2025EweitzAdd more interactions
141938view13:17, 28 November 2025EweitzAdd literature references
141937view12:58, 28 November 2025EweitzAdd GDF11, economize layout
141936view01:52, 28 November 2025EweitzAdd FASLG, economize layout
141935view16:13, 27 November 2025EweitzRefine layering
141934view16:12, 27 November 2025EweitzRefine gene distributions
141933view16:01, 27 November 2025EweitzUpdate title
141932view15:47, 27 November 2025EweitzRefine layering
141931view15:47, 27 November 2025EweitzAdd stage dividers
141930view15:36, 27 November 2025EweitzAdd gene distributions
141929view15:18, 27 November 2025EweitzUse gene symbol, note alias
141919view02:05, 27 November 2025EweitzGroup cell types, add more gene distributions
141918view01:13, 27 November 2025EweitzRefine distributions
141917view01:05, 27 November 2025EweitzUpdate distribution colors, label them
141916view00:49, 27 November 2025EweitzUpdate distribution fill color
141915view00:38, 27 November 2025EweitzAdd distributions
141914view00:02, 27 November 2025EweitzAdd distribution
141913view23:56, 26 November 2025EweitzFill distribution
141912view23:45, 26 November 2025EweitzRefine distribution
141911view23:45, 26 November 2025EweitzRefine distribution
141910view23:44, 26 November 2025EweitzRefine distribution
141909view23:38, 26 November 2025EweitzAdd primitive distribution
141908view23:33, 26 November 2025EweitzAdd genes
141907view23:20, 26 November 2025EweitzAdd anatomical context
141906view22:52, 26 November 2025EweitzShrink nucleus in orthoEB and pyrenocyte, enlarge in proEB
141905view22:43, 26 November 2025EweitzAdd pyrenocyte
141904view22:38, 26 November 2025EweitzAlign labels with cells
141903view22:28, 26 November 2025EweitzAdd more cell type labels
141901view13:57, 26 November 2025EweitzLabel cell types
141900view12:59, 26 November 2025EweitzStandardize space between cells
141899view12:55, 26 November 2025EweitzThin cell membrane

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CD34GeneProductENSG00000174059 (Ensembl)
CD79AGeneProductENSG00000105369 (Ensembl) "IgA" in source
EPOGeneProductENSG00000130427 (Ensembl)
EPORGeneProductENSG00000187266 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
GATA1GeneProductENSG00000102145 (Ensembl)
GATA2GeneProductENSG00000179348 (Ensembl)
GDF11GeneProductENSG00000135414 (Ensembl)
GYPAGeneProductENSG00000170180 (Ensembl) "CD235a" in source
HBA1GeneProductENSG00000206172 (Ensembl)
HBA2GeneProductENSG00000188536 (Ensembl)
HBBGeneProductENSG00000244734 (Ensembl)
HBDGeneProductENSG00000223609 (Ensembl)
HBE1GeneProductENSG00000213931 (Ensembl)
HBG1GeneProductENSG00000213934 (Ensembl)
HBG2GeneProductENSG00000196565 (Ensembl)
HBZGeneProductENSG00000130656 (Ensembl)
IL3GeneProductENSG00000164399 (Ensembl)
IL3RAGeneProductENSG00000292332 (Ensembl)
KITGeneProductENSG00000157404 (Ensembl)
KITLGGeneProductENSG00000049130 (Ensembl)
PTPRCGeneProductENSG00000081237 (Ensembl) "CD45" in source
TFGeneProductENSG00000091513 (Ensembl) "CD71" in source
TFRCGeneProductENSG00000072274 (Ensembl) "CD71" in source

Annotated Interactions

No annotated interactions

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